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How to Evaluate Dietary Protein

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Milk Proteins

Abstract

The presentation of a paper on “How to evaluate dietary protein” might be approached in a number of ways, depending upon the depth and breadth of the coverage given to specific, relevant areas that could reasonably be included under this title. The primary nutritional function of dietary protein is to furnish the indispensable (essential) amino acids and total nitrogen required for synthesis of tissue and organ proteins and many other nitrogen-containing compounds necessary for normal growth and function of the organism. Hence, in the first instance, it is usual to consider the different food proteins and protein sources in relation to their capacity to meet the amino acid and nitrogen requirements of the host. On the other hand, a more comprehensive evaluation of dietary protein on the overall nutritional health of the individual and of populations, requires an assessment of the possible effects of various food protein sources on the utilization of, and requirements for, energy yielding substrates and other individual essential nutrients (e.g., [1]). Because later papers in this symposium will be devoted to milk proteins with reference to the utilization of, and requirements for, minerals and other micronutrients, as well as considering use of milk proteins in relation to various aspects of clinical nutrition, we have chosen the first instance above as our principal focus with respect to the “evaluation of dietary protein”. In doing so, we will consider some recent research that, while still somewhat controversial (e.g., [2]), provides a new, and we believe, a more rational basis for judging the significance of milk proteins in human protein and amino acid nutrition.

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References

  1. Young VR (1981) Food protein sources: Implications of nutrient requirements. In: Selvey N, White PL (eds) Nutrition in the 1980s: Constraints on our knowledge. Alan R. Liss, Inc., New York, NY, pp 189–206

    Google Scholar 

  2. Young VR (1981) Food protein sources: Implications of nutrient requirements. In: Selvey N, White PL (eds) Nutrition in the 1980s: Constraints on our knowledge. Alan R. Liss, Inc., New York, NY, pp 189–206

    Google Scholar 

  3. Bender AE (1983) Protein evaluation. In: Kaufmann W (ed) Role of milk proteins in human nutrition. Kieler Milchwirtschaftliche Forschungsberichte 35: 267–273

    Google Scholar 

  4. Young VR, Pellett PL (1985) Wheat proteins in relation to protein requirements and availability of amino acids. Am J Clin Nutr 42: 1077–1090

    Google Scholar 

  5. Pellett PL, Young VR (eds) (1980) Nutritional value of protein foods. United National University, World Hunger Program; Food and Nutrition Bulletin, Supplement 4. United Nations University, Tokyo, pp 154

    Google Scholar 

  6. Porter JWG, Rolls BA (eds) (1973) Proteins in human nutrition. New York, Academic Press, pp 560

    Google Scholar 

  7. Bodwell CE, Adkins JS, Hopkins DT (eds) (1981) Protein quality in humans: Assessment and in vitro estimation. AVI Publishing Co., Inc., Westport, Connecticut, pp 435

    Google Scholar 

  8. Young VR (1983) Human studies for evaluation of protein quality with particular reference to milk proteins. In: Kaufmann W (ed) Role of milk proteins in human nutrition. Kieler Milch-wirtschaftliche Forschungsberichte 35: 247–265

    Google Scholar 

  9. Young VR, Pellett PL (1985) Milk proteins with reference to human needs, and world food supply and nutritional situation. In: Galesloot TE, Tinbergen BJ (eds) Milk proteins 1984. Pudoc, Wageningen, Netherlands, pp 18–46

    Google Scholar 

  10. Räihä NCR (1980) Protein in the nutrition of the pre-term infant: Biochemical and nutritional considerations. Adv Nutr Res 3: 173–206

    Google Scholar 

  11. Hambraeus L (1985) Importance of milk proteins in human nutrition: physiological aspects. In: Gallsloot TE, Tinbergen BJ (eds) Milk proteins ‘84. Pudoc, Wageningen, Netherlands, pp 63–79

    Google Scholar 

  12. Finke MD, DeFoliart GR, Benevenga NJ (1987) Use of simultaneous curve fitting and a four-parameter logistic model to evaluate the nutritional quality of protein sources at growth rates of rats from maintenance to maximum gain. J Nutr 117: 1681–1688

    PubMed  CAS  Google Scholar 

  13. Phillips RD (1981) Linear and non-linear models for measuring protein nutritional quality. J Nutr 111: 1058–1066

    PubMed  CAS  Google Scholar 

  14. Phillips RD (1982) Modification of the saturation kinetics model to produce a more versatile protein quality assay. J Nutr 112: 468–473

    PubMed  CAS  Google Scholar 

  15. Mercer LP (1982) The quantitative nutrient-response relationship. J Nutr 112: 560–566

    PubMed  CAS  Google Scholar 

  16. Young VR, Rand WM, Scrimshaw NS (1977) Measuring protein quality in humans: a review and proposed method. Cereal Chem 54: 929–948

    CAS  Google Scholar 

  17. Fomon SJ, Ziegler E, Nelson SE, Edwards BB (1986) Requirement of sulfur-containing amino acids in infancy. J Nutr 116: 1405–1422

    PubMed  CAS  Google Scholar 

  18. Pellett PL, Young CR (1984) Background paper 4: Evaluation of the use of amino acid composition data in assessing the protein quality of meat and poultry products. Am J Clin Nutr 40: 718–736

    Google Scholar 

  19. Young VR, Pellett PL (1984) Background paper 5: Amino acid composition in relation to protein nutritional quality of meat and poultry products. Am J Clin Nutr 40: 737–742

    Google Scholar 

  20. Young VR, Fukagawa NK, Storch KJ, Hoerr R, Jaksic T (1988) Stable isotope probes: Potential for application in studies of amino acid utilization in the neonate. In: Lindblad BS (ed) Perinatal nutrition. Academic Press, Inc., San Diego, California, pp 221–241

    Google Scholar 

  21. Young VR, Moldawer LL, Hoerr R, Bier DM (1985) Mechanisms of adaptation to protein malnutrition. In: Blaxter KL, Waterlow JC (eds) Nutritional adaptation in mMan. John Libbey, London, pp 189–215

    Google Scholar 

  22. Waterlow JC, Garlick PJ, Millward DJ (1978) Protein turnover in mammalian tissues and in the whole body. North Holland, Amsterdam, pp 804

    Google Scholar 

  23. Young VR, Fukagawa NK, Bier DM, Matthews D (1986) Some aspects of in vivo human protein and amino acid metabolism, with particular reference to nutritional modulation. Verhandlungen der Deutschen Gesellschaft für Innere Medizin, 92. Band. Bergmann, München, pp 639–665

    Google Scholar 

  24. Munro HN (1970) Free amino acid pools and their role in regulation. In: Munro HN (ed) Mammalian Protein Metabolism, vol. IV, pp 229–386

    Google Scholar 

  25. Kang-Lee TA, Harper AE (1977) Effect of histidine intake and hepatic histidase activity on the metabolism of histidine in vivo. J Nutr 107: 1427–1443

    PubMed  CAS  Google Scholar 

  26. Harper AE, Benjamin A (1984) Relationship between intake and rate of oxidation of leucine and a-ketoisocaproate in vivo in the rat. J. Nutr 114: 57–62

    Google Scholar 

  27. Young VR, Meredith C, Hoerr R, Bier DM, Matthews DE (1985) Amino and kinetics in relation to protein and amino acid requirements: the primary importance of amino acid oxidation. In: Garrow JS, Halliday D (eds) Substrate and energy metabolism in man. John Libbey, London, pp 119–133

    Google Scholar 

  28. Young VR, Gucalp C, Rand WM, Matthews DE, Bier DM (1987) Leucine kinetics during three weeks at submaintenance-to-maintenance intakes of leucine in men: Adaptation and accommodation. Hum Nutr Clin Nutr 41 C: 1–18

    Google Scholar 

  29. Waterlow JC (1985) What do we mean by adaptation? In: Blaxter KL, Waterlow JC (eds) Nutritional adaption in man. John Libbey, London, pp 1–10

    Google Scholar 

  30. FAO/WHO/UNU (1985) Energy and protein requirements. Tech Rept Ser No 724, World Health Organization, Geneva

    Google Scholar 

  31. Hegsted DM (1976) Balance studies. J Nutr 106: 307–311

    Google Scholar 

  32. Young VR (1986) Nutritional balance studies: indicators of human requirements or of adaptive mechanisms? J Nutr 116: 700–703

    PubMed  CAS  Google Scholar 

  33. NRC (1974) Improvement of protein nutriture. Food and Nutrition Board, National Academy of Sciences, Washington DC

    Google Scholar 

  34. Young VR, Meguid M, Meredith C, Matthews DE, Bier DM (1981) Recent developments in knowledge of human amino acid requirements. In: Waterlow JC, Stephen JML (eds) Nitrogen metabolism in man. Applied Science Publishers, London, pp 133–153

    Google Scholar 

  35. Meredith C, Bier DM, Meguid MM, Matthews DE, Wen Z, Young VR (1982) Whole body amino acid turnover with 13C-tracers: a new approach for estimation of human acid requirements. In: Wesdorp RIC, Soeters PB (eds) Clinical nutrition ‘81. Churchill Livingston, London, pp 42–59

    Google Scholar 

  36. Meguid MM, Matthews DE, Bier DM, Meredith CN, Soeldner JS, Young VR (1986) Leucine kinetics at graded leucine intakes in young men. Am J Clin Nutr 43: 370–380

    Google Scholar 

  37. Meguid MM, Matthews DE, Bier DM, Meredith CN, Young VR (1986) Valine kinetics at graded valine intakes in young men. Am J Clin Nutr 43: 781–786

    PubMed  CAS  Google Scholar 

  38. Meredith CM, Wen Z-W, Bier DM, Matthews DE, Young VR (1986) Lysine kinetics at graded lysine intakes in young men. Am J Clin Nutr 43: 787–794

    PubMed  CAS  Google Scholar 

  39. Zhao X-L, Wen Z-W, Meredith CM, Matthews DE, Bier DM, Young VR (1986) Threonine kinetics at graded threonine intakes in young men. Am J Clin Nutr 43: 795–802

    PubMed  CAS  Google Scholar 

  40. Waterlow JC (1986) Metabolic adaptation to low intakes of energy and protein. Ann Rev Nutr 6: 495–526

    Article  CAS  Google Scholar 

  41. Young VR, Bier DM, Pellett PL (1988) A theoretical basis for increasing current estimates of the amino acid requirements in adult man, with experimental support. Am J Clin Nutr (submitted)

    Google Scholar 

  42. Motil KJ, Matthews DE, Bier DM, Burke JF, Munro HN, Young VR (1981) Whole-body leucine and lysine metabolism: response to dietary protein intake in young men. Am J Physiol 240:E 712-E 721

    Google Scholar 

  43. Steffee WP, Goldsmith RS, Pencharz PB, Scrimshaw NS, Young VR (1976) Dietary protein intake and dynamic aspects of whole body nitrogen metabolism in adult humans. Metabolism 25: 281–297

    Article  PubMed  CAS  Google Scholar 

  44. Calloway DH, Margen S (1971) Variation in endogenous nitrogen excretion and dietary nitrogen utilization as determinants of human protein requirement. J Nutr 101: 205–216

    PubMed  CAS  Google Scholar 

  45. Young VR, Taylor YSM, Rand WM, Scrimshaw NS (1973) Protein requirements of man: Efficiency of egg protein utilization at maintenance and submaintenance levels in young men. J Nutr 103: 1164–1174

    Google Scholar 

  46. Yoshida A, Ashida K (1969) Pattern of essential amino acid requirement for growing rats fed on a low amino acid diet. Agric Biol Chem 33: 43–49

    Article  CAS  Google Scholar 

  47. Said AK, Hegsted DM (1970) Response of rats to diets of equal chemical essential amino acids. J Nutr 100: 1363–1376

    PubMed  CAS  Google Scholar 

  48. Cieslak DG, Benevenga NJ (1886) Response of rats to diets of equal chemical score: Effect of lysine and threonine as the limiting amino acid and of an amino acid excess. J Nutr 166: 969–977

    Google Scholar 

  49. Cieslak DG, Benevenga NJ (1984) The effect of amino acid excess on utilization by the rat of limiting amino acid-threonine. J Nutr 114: 1871–1877

    PubMed  CAS  Google Scholar 

  50. Cieslak DG, Benevenga NJ (1984) The effect of amino acid excess on utilization by the rat of limiting amino acid -lysine and threonine at equalized food intakes. J Nutr 114: 1878–1883

    PubMed  CAS  Google Scholar 

  51. FAO/WHO (1973) Energy and protein requirements. Report of a Joint FAO/WHO ad hoc Expert Committee. WHO Tech Rep Ser No. 522. World Health Organization, Geneva

    Google Scholar 

  52. FAO (1957) Protein requirements. FAO Nutr Studies No. 16. Food and Agriculture Organization, Rome

    Google Scholar 

  53. FAO/WHO (1965) Protein requirements. FAO Nutr Meetings Rep Ser No. 37. Food and Agriculture Organization, Rome

    Google Scholar 

  54. Williams HH, Harper AE, Hegsted DM, Arroyave G, Holt LE Jr (1974) Nitrogen and amino acid requirements. In: Improvement of protein nutriture. US Food and Nutrition Board, National Academy of Science, Washington DC, pp 23–63

    Google Scholar 

  55. FAO/WHO (1975) Energy and protein requirements: recommendations by a joint FAO/WHO informal gathering of experts. Food and Nutrition 1 (2): 11–19

    Google Scholar 

  56. Young VR, Puiz M, Querioz E, Scrimshaw NS, Rand WM (1984) Evaluation of the protein quality of an isolated soy protein in young men: relative nitrogen requirements and effect of methionine supplementation. Am J Clin Nutr 39: 16–24

    PubMed  CAS  Google Scholar 

  57. Perissé J, Sizaret F, François P (1969) The effect of income on the structure of the diet. Nutrition Newsletter 7:1–10. FAO, Rome

    Google Scholar 

  58. UNICEF (1987) The state of the world’s children 1987. UNICEF, New York, NY 1987

    Google Scholar 

  59. FAO (1980) Food Balance Sheets 1975–1977. Average and Per Caput Food Supplies 1961–1965 and 1967–1977. Food and Agricultural Organization, Rome

    Google Scholar 

  60. FAO (1984) Food Balance Sheets 1979–1981. Food and Agriculture Organization, Rome

    Google Scholar 

  61. FAO (1985) The Fifth World Food Survey. Food and Agriculture Organization, Rome, 129 pages

    Google Scholar 

  62. FAO (1985) The Fifth World Food Survey. Food and Agriculture Organization, Rome, 129 pages

    Google Scholar 

  63. Pellett PL (1987) Determinants of nutritional status. Food and Nutrition 13:2–14. FAO, Rome

    Google Scholar 

  64. USDA (1983) Food intakes: Individuals in 48 states, year 1977–1978. Consumer Nutrition Division Human Nutrition Information Service, US Dept. of Agriculture. Hyattsville, MD 20782. Nationwide Food Consumption Survey 1977–1978. Report No. I - 1

    Google Scholar 

  65. FAO (1970) Amino acid content of foods and biological data on proteins. FAO Nutritional Studies No 24. Food and Agriculture Organization, Rome

    Google Scholar 

  66. FAO (1986) Country tables: basic data on the agriculture sector. Economic and Social Policy Department. Food and Agriculture Organization, Rome

    Google Scholar 

  67. FAO (1986) Country tables: basic data on the agriculture sector. Economic and Social Policy Department. Food and Agriculture Organization, Rome

    Google Scholar 

  68. Cameron M, Hofvander Y (1983) Manual of Feeding Infants and Young Children, 3rd Edition. UN/ACC Subcommittee on Nutrition — Oxford University Press, Oxford, p 214

    Google Scholar 

  69. Pellett PL, Mamarbachi D (1979) Recommended proportions of foods in home-made feeding mixtures. Ecol Food Nutr 7: 219–228

    Article  CAS  Google Scholar 

  70. Pellett PL, Pellett AY (1983) Food mixtures for combatting childhood malnutrition. In: Rechcigl M (ed) Handbook of nutritional supplements, vol 1.Human Use. CRC Press, Boca Raton, Florida, pp 411–480

    Google Scholar 

  71. Mathew SP, Pellett PL (1986) Protein Quality of homemade weaning food mixtures: 1. Biological evaluation and quality. Ecol Food Nutr 19: 31–40

    Google Scholar 

  72. Pellett PL, Mathew SP (1986) Protein quality of homemade weaning food mixtures: 2. Amino acid composition versus biological methods. Ecol Food Nutr 19: 41–49

    Google Scholar 

  73. NAS/NRC (National Academy of Sciences — National Research Council) (1980) Recommended dietary allowances. 9th edition. National Academy of Sciences, Washington DC, pp 185

    Google Scholar 

  74. Herbert V (1987) Recommended dietary intakes (RDI) of vitamin B12 in humans. Am J Clin Nutr 45: 671–678

    PubMed  CAS  Google Scholar 

  75. Pellett PL, Shadarevian S (1970) Food composition tables for use in the Middle East. 2nd Edition. American University of Beirut, Lebanon, pp 116

    Google Scholar 

  76. Pennington JAT, Church HN (1985) Bowes and Church’s food values of portions commonly used. 14th Edition. JB Lippincott Co., Philadelphia, pp 257

    Google Scholar 

  77. Jelliffe DB, Jellife EFP (1979) The uniqueness of human milk. Am J Clin Nutr 24: 968–1024

    Google Scholar 

  78. Hambraeus L, Sjölin S (1979) The mother-child dyad — nutritional aspects. Almquist and Wiksell International, Stockholm, Sweden

    Google Scholar 

  79. Fomon SJ (1974) Infant nutrition. 2nd Edition. WB Saunders Co., Philadelphia

    Google Scholar 

  80. Cockburn F (1983) Milk composition; the infant human diet. Pro Nutr Soc 42: 361–372

    Article  CAS  Google Scholar 

  81. Pellett PL, Young VR (1988) National and international implications of revised estimates of human adult needs for indispensable amino acids (submitted for publication)

    Google Scholar 

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© 1989 Dr. Dietrich Steinkopff Verlag GmbH & Co. KG, Darmstadt

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Young, V.R., Pellett, P.L. (1989). How to Evaluate Dietary Protein. In: Barth, C.A., Schlimme, E. (eds) Milk Proteins. Steinkopff. https://doi.org/10.1007/978-3-642-85373-9_3

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  • DOI: https://doi.org/10.1007/978-3-642-85373-9_3

  • Publisher Name: Steinkopff

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