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New Aspects of Hypertrophic Cardiomyopathy pp 267–275Cite as

Comparison of verapamil and bepridil in the therapy of familiar cardiomyopathy of the Syrian hamster

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Abstract

The effect of verapamil on the cardiomyopathic hamster is wellknown from the basic works of Loßnitzer (6–9). It is not known, however, whether different calcium-antagonists have the same cardioprotective potency. In this study we analyzed the effect of bepridil, on the cardiomyopathic hamster. Bepridil is shown to be a calcium antagonistic drug (10) with documented antianginal (1) in humans efficacy.

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References

  1. Canicave JC, Den J, Jacq Z, Paillet R (1980) Therapie 35: 607

    PubMed  CAS  Google Scholar 

  2. Factor S, Minase T, Cho S, Dominitz R, Sonnenblick E (1985) Microvascular spasm in the cardiomyopathic Syrian hamster: A preventable cause of focal myocardial necrosis. Circulation 66: 342–354

    Article  Google Scholar 

  3. Fleckenstein A, Janke J, Döring HJ, Leder O (1971) Die intracelluläre Überladung mit Calcium als entscheidender Kausalfaktor bei der Entstehung nicht coronarogener Myokardnekrosen. Verh Dtsch Ges Kreislaufforsch 37: 345–353

    Article  PubMed  CAS  Google Scholar 

  4. Fleckenstein A, Janke J, Döring HJ, Pachinger O (1973) Ca overload the determinant factor in the production of catecholamine-induced myocardial lesion. In: Bajusz E, Rona G (eds) Cardiomyopathies. Recent in the Study of Cardiac Structural Metabolism. Advances Vol 2. University Park Press, Baltimore—London—Tokyo, pp 455–466

    Google Scholar 

  5. Fleckenstein A, Frey M, Keidel JJ (1982) Prevention by Verapamil of Isoproterenol-induced hypertrophie cardiomyopathy in rats. In: M Kaltenbach, S Epstein (eds) Hypertrophie cardiomyopathy. Springer Verlag, Berlin—Heidelberg-New York, pp 113–120

    Google Scholar 

  6. Loßnitzer K, Steinhard B, Grewe N, Stauch M (1975) Charakteristische Elektrolytveränderungen bei der erblichen Kardiomyopathie des Syrischen Goldhamsters (Stamm Bio 8262). Basic Res Cardiol 70: 508–520

    Article  PubMed  Google Scholar 

  7. Loßnitzer K, Konrad A, Zeger D, Mohr W (1982) Prevention of myocardial cell necrosis in the Syrian hamster. Results of long-term treatment. In: M Kaltenbach, S Epstein (eds) Hypertrophie Cardiomyopathy. Springer Verlag, Berlin—Heidelberg—New York, pp 99–114

    Chapter  Google Scholar 

  8. Loßnitzer K (1975) Genetic Induction of a Cardiomyopathy. In: Born GVR, Eichler O, Farah A, Herken H, Welch AD (eds) Handbuch der experimentellen Pharmakologie. Vol XVI/3, Springer Verlag, Berlin—Heidelberg—New York, pp 309–344

    Google Scholar 

  9. Mohr W, LoBnitzer K (1974) Morphologische Untersuchungen an Hamstern des Stammes Bio 8262 mit erblicher Myopathie und Kardiomyopathie. Beitr Path 153: 178–193

    CAS  Google Scholar 

  10. Murphy KMM; Gould RJ, Largent BJ, Snyder SH (1983) Proc Natl Acad Sci USA 80: 860

    Article  PubMed  CAS  Google Scholar 

  11. Weibel E, Kistler GS, Scherle WF (1966) Practical stereological methods for morphometric cytology. J Cell Biol 30: 23–38

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Medizinische Poliklinik, Universität Erlangen, Germany

    Prof. Dr. B. Kunkel, U. Hofmann & M. Mutschler

  2. Institut für Pharmakologie, Universität Frankfurt, Germany

    Prof. Dr. B. Kunkel, U. Hofmann & M. Mutschler

  3. Medizinische Poliklinik, Universität Erlangen, Östliche Stadtmauerstraße 29, 8520, Erlangen, Germany

    Prof. Dr. B. Kunkel

Authors
  1. Prof. Dr. B. Kunkel
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  2. U. Hofmann
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  3. M. Mutschler
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Editor information

Editors and Affiliations

  1. Abteilung Kardiologie, Zentrum Innere Medizin, Theodor-Stern-Kai 7, 6000, Frankfurt 70, Germany

    M. Kaltenbach  & R. Hopf  & 

  2. Medizinische Poliklinik, Universität Erlangen, Östliche Stadtmauerstraße 29, 8520, Erlangen, Germany

    B. Kunkel

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© 1988 Dr. Dietrich Steinkopff Verlag GmbH & Co. KG, Darmstadt

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Kunkel, B., Hofmann, U., Mutschler, M. (1988). Comparison of verapamil and bepridil in the therapy of familiar cardiomyopathy of the Syrian hamster. In: Kaltenbach, M., Hopf, R., Kunkel, B. (eds) New Aspects of Hypertrophic Cardiomyopathy. Steinkopff. https://doi.org/10.1007/978-3-642-85369-2_26

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  • DOI: https://doi.org/10.1007/978-3-642-85369-2_26

  • Publisher Name: Steinkopff

  • Print ISBN: 978-3-642-85371-5

  • Online ISBN: 978-3-642-85369-2

  • eBook Packages: Springer Book Archive

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