Dynamic obstruction to left ventricular outflow: The case for its existence in hypertrophic cardiomyopathy

  • Barry J. Maron
  • S. E. Epstein
Conference paper

Abstract

Obstruction to left ventricular outflow is a feature of hypertrophic cardiomyopathy (HCM) that has been of great interest to clinicians and students of this disease for over 25 years, and while generally regarded as a prominent and important component of HCM, its clinical and pathophysiologic significance has been the source of periodic and often intense disagreement and controversy (1–20). In the early 1960s, a number of investigators observed that those patients with HCM and a loud systolic heart murmur had markedly increased systolic pressure and a pressure gradient recorded within the left ventricle at cardiac catheterization (5, 21–23). This subaortic gradient could easily be distinguished from gradients artifactually produced by physical entrapment of the catheter between left ventricular trabeculations (3–5). It was therefore concluded that true obstruction to left ventricular outflow existed in these patients with HCM.

Keywords

Catheter Ischemia Lactate Radio Nuclide Eter 

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Copyright information

© Dr. Dietrich Steinkopff Verlag GmbH & Co. KG, Darmstadt 1988

Authors and Affiliations

  • Barry J. Maron
    • 1
    • 2
  • S. E. Epstein
    • 1
  1. 1.Cardiology Branch, National Heart, Lung, and Blood InstituteNational Institutes of HealthBethesdaUSA
  2. 2.National Institutes of Health National Heart, Lung, and Blood InstituteBethesdaUSA

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