Advertisement

Was kann man mit einer Adjuvansarthritis anfangen?

Conference paper
Part of the Der Rheumatismus book series (2798, volume 45)

Zusammenfassung

Die Adjuvansarthritis der Ratte ist die artikuläre Manifestation der „Adjuvanskrank- heit“, die mit Läsionen in verschiedenen Organen einhergeht. Ihre „Ätiologie“ ist das intradermal oder subkutan injizierte komplette Freundsche Adjuvans (KFA) — ihre vorwiegenden Symptome sind Polyarthritis, Osteomyelitis, Dermatitis, Iridozyklitis, Konjunktivitis, Urethritis, Bronchitis und Pankarditis.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Anderte SK, Greenblatt JJ, Cromartie WJ, Clark R, Schwab JH (1979) Modulation of the susceptibility of inbred and outbred rats to arthritis induced by cell walls of group A streptococci. Infect Immun 25:484–490Google Scholar
  2. Arumugham R, Bose SM (1980) Glycohydrolases and lysosomal stability in adjuvant induced arthritis. Ital J Biochem 29:27–40PubMedGoogle Scholar
  3. Best R, Christian R, Lewis DA (1984) Effect of particle size of dried mycobacteria on adjuvant induced arthritis in the rat. Agents Actions 14:265–268PubMedCrossRefGoogle Scholar
  4. Binderup L (1983) Decreased T-suppressor cell activity in rats with adjuvant arthritis. Ann Rheum Dis 42:693–698PubMedCrossRefGoogle Scholar
  5. Binderup L, Bramm E, Arrigoni-Martelli E (1979) Peritoneal macrophages from adjuvant arthritic rats enhance tumour cell growth in vitro. Experientia 35:1230–1232PubMedCrossRefGoogle Scholar
  6. Carmichael DJ, Gillard GC, Lowther DA, Handley CJ, Santer VB (1977) Carrageenin-induced arthritis. Arthritis Rheum 20:834–840PubMedCrossRefGoogle Scholar
  7. Caulfield JP, Hein A, Dynesius-Trentham R, Trentham DE (1982) Morphologic demonstration of two stages in the development of type II collagen-induced arthritis. Lab Invest 46:321–343PubMedGoogle Scholar
  8. Chang YH, Pearson CM, Chedid L (1981) Adjuvant polyarthritis. V. Induction by N-acetyl-muramyl-L-alanyl-D-isoglutamine, the smallest peptide subunit of bacterial peptidoglycan. J ExpMed 153:1021–1026Google Scholar
  9. Clark RL, Cuttino JT, Anderte SK, Cromartie WJ, Schwab JH (1979) Radiologic analysis of arthritis in rats after systemic injection of streptococcal cell walls. Arthritis Rheum 22:25–35PubMedCrossRefGoogle Scholar
  10. Coffey JW, Salvador RA (1981) Levels of collagenolytic activity, beta-glucuronidase, and collagen prolyl hydroxylase in paws from rats with developing adjuvant arthritis. Biochim Biophys Acta 677:243–252PubMedCrossRefGoogle Scholar
  11. Collier DH, Kerwar SS, Garovoy MR, Fye KH, Stobo JD (1984) Anticollagen antibodies and immune response gene products in rheumatoid arthritis. Arthritis Rheum 27:1201–1209PubMedCrossRefGoogle Scholar
  12. Colombo C, Steele RE, Leathern JH, Steinetz BG (1979) An emphysema-like reaction in lungs of adjuvant arthritic rats. Proc Soc Exp Biol Med 161:225–234PubMedGoogle Scholar
  13. Colpaert FC, De Witte P, Maroli AN, Awouters F, Niemegeers CJ, Janssen PA (1980) Self-administration of the analgesic suprofen in arthritic rats: experimental model of chronic pain. Life Sci 27:921–928PubMedCrossRefGoogle Scholar
  14. Colpaert FC, Meert T, De Witte P, Schmitt P (1982) Further evidence validating adjuvant arthritis as an experimental model of chronic pain in the rat. Life Sci 31:67–75PubMedCrossRefGoogle Scholar
  15. Dalldorf FG, Cromartie WJ, Anderle SK, Clark RL, Schwab JH (1980) The relation of experimental arthritis to the distribution of streptococcal cell wall fragments. Am J Pathol 100:383–402PubMedGoogle Scholar
  16. DeCastro Costa M, De Sutter P, Gybels J, Van Hees J (1981) Adjuvant-induced arthritis in rats: a possible animal model of chronic pain. Pain 10:173–185CrossRefGoogle Scholar
  17. DeLustro F, Carison RP, Datko LJ, De Lustro B, Lewis AJ (1984) The absence of antibodies to type II collagen in established adjuvant arthritis in rats. Agents Actions 14:673–679CrossRefGoogle Scholar
  18. DeSimone DP, Parsons DB, Johnson KE, Jacobs RP (1983) Type II collagen-induced arthritis. Arthritis Rheum 26:1245–1258CrossRefGoogle Scholar
  19. Dingle JT (1979) Recent studies on the control of joint damage: the contribution of the Strange-ways Research Laboratory. Ann Rheum Dis 38:201–214PubMedCrossRefGoogle Scholar
  20. Georoeg P, Kovacs IB (1979) Experimental inflammation and tumor growth: chemical carcino-genesis in adjuvant arthritic rats. Inflammation 3:359–364CrossRefGoogle Scholar
  21. Gillard GC, Lowther DA (1976) Carrageenin induced arthritis. Arthritis Rheum 19:918–926PubMedCrossRefGoogle Scholar
  22. Gilman SC, Daniels JF, Wilson RE, Carlson RP, Lewis AJ (1984) Lymphoid abnormalities in rats with adjuvant-induced arthritis. I. Mitogen responsiveness and lymphokine synthesis. Ann Rheum Dis 43:847–855Google Scholar
  23. Henderson B (1984) Increase in the activity of lysosomal acid hydrolases in the chondrocytes of arthritic joints of rabbits with experimental allergic arthritis. Histochem J 16:287–293PubMedCrossRefGoogle Scholar
  24. Holoshitz J, Matitiau A, Cohen IR (1984) Arthritis induced in rats by cloned T lymphocytes responsive to mycobacteria but not to collagen type II. J Clin Invest 73:211–215PubMedCrossRefGoogle Scholar
  25. Iizuka Y, Chang YH (1982) Adjuvant polyarthritis. VII. The role of type II collagen in patho-genesis. Arthritis Rheum 25:1325–1332Google Scholar
  26. Kaibara N, Hotokebuchi T, Takagashi K, Katsuki I, Morinaga M, Arita C, Jingushi S (1984) Pathogenetic difference between collagen arthritis and adjuvant arthritis. J Exp Med 159:1388–1396PubMedCrossRefGoogle Scholar
  27. Kapusta MH, Young-Rodenchuk M, Kourounakis L (1979) Restoration of diminished splenic responses to phytohemagglutinin and concanavalin A in adjuvant-induced disease by virazole: possible pathogenetic role of a virus and suppressor cells. J Rheumatol 6:507–518PubMedGoogle Scholar
  28. Kohashi O, Tanaka A, Kotani S, Shiba T, Kusumoto S, Yokogawa K, Kawata S, Ozawa A (1980) Arthritis-inducing ability of a synthetic adjuvant, N-acetylmuramyl peptides, and bacterial di-saccharide peptides related to different oil vehicles and their composition. Infect Immun 29:70–75PubMedGoogle Scholar
  29. Kohashi O, Pearson CM, Tamaoki N, Tanaka A, Shimamura K, Ozawa A, Kotani S, Saito M, Hioki K (1981) Role of thymus for N-acetylmuramyl-L-alanyl-D-isoglutamine-induced polyarthritis and granuloma formation in euthymic and athymic nude rats or in neonatally thymectomized rats. Infect Immun 31:758–766PubMedGoogle Scholar
  30. Kohashi O, Aihara K, Ozawa A, Kotani S, Azuma I (1982) New model of a synthetic adjuvant. N-acetylmuramyl-L-alanyl-D-isoglutamine-induced arthritis: clinical and histologie studies in athymic nude and euthymic rats. Lab Invest 47:27–36Google Scholar
  31. Kruijsen MWM, van der Berg WB, van de Putte LBA (1983) Damage to chondrocytes: the significance of severity of inflammation. Clin Rheumatol 2:86 (Abstr)Google Scholar
  32. Kuberasampath T, Bose SM (1979) Influence of prednisolone and L-thyroxine on the changes in collagen metabolism in rats with adjuvant-induced arthritis. Agents Actions 9:502–509PubMedCrossRefGoogle Scholar
  33. Lehman TJA, Allen JB, Plotz PH, Wilder RL (1984) Lactobacillus casei cell wall-induced arthritis in rats: cell wall fragment distribution and persistence in chronic arthritis-susceptible LEW/N and-resistant F344/N rats. Arthritis Rheum 27:939–942PubMedCrossRefGoogle Scholar
  34. Lussier A, de Medicis R, Tetreault L (1981) Adjuvant arthritis: influence of the adjuvant volume and composition on the non-specific inflammation. Int J Tissue React 3:11–15PubMedGoogle Scholar
  35. Mohr W (1974) Pathologische Anatomie und experimentelle Pathologie rheumatischer Erkrankungen. In: Neuheimer Fortbildungs-Lehrgänge. Band 38: Erworbene Herzfehler — Entzündlicher Rheumatismus. Steinkopff, Darmstadt, S 76–104Google Scholar
  36. Mohr W(1984) Gelenkkrankheiten. Thieme, Stuttgart New York 1984Google Scholar
  37. Mohr W, Wild A (1976 a) Der Ablauf der Adjuvanskrankheit bei Ratten des Stammes AF/Han-EMD-SPF. Z Rheumatol 35:77–90PubMedGoogle Scholar
  38. Mohr W, Wild A (1976 b) Morphologische Untersuchungen an Ratten mit langdauernder Adjuvanskrankheit. Z Rheumatol 35:301–311PubMedGoogle Scholar
  39. Mohr W, Wild A (1976c) Adjuvant arthritis. Arzneim Forsch (Drug Res) 26:1860–1866Google Scholar
  40. Mohr W, Wild A (1977 a) The proliferation of chondrocytes and pannus in adjuvant arthritis. Vir-chows Arch B Cell Pathol 25:1–16Google Scholar
  41. Mohr W, Wild A (1977 b) Autoradiographische Untersuchungen zur Pannusentwicklung bei der Adjuvansarthritis der Ratte. Wien Klin Wochenschr 89:756–765PubMedGoogle Scholar
  42. Mohr W, Wild A, Beneke G (1974) Chronische Osteomyelitis als Manifestation der Adjuvanskrankheit der Ratte. Beitr Pathol 153:1–17PubMedCrossRefGoogle Scholar
  43. Mohr W, Wild A, Paulini K (1975 a) Proliferation of synovial tissue cells in rats with adjuvant disease. Pathol Microbiol 43:1–9Google Scholar
  44. Mohr W, Hersener J, Wild A, Paulini K (1975 b) Untersuchungen zum Knorpelabbau bei der Adjuvansarthritis der Ratte. Z Rheumatol 34:234–242PubMedGoogle Scholar
  45. Mohr W, Wild A, Wolf HP (1978) Incorporation of 3H-proline into hyaline articular cartilage. Virchows Arch [Cell Pathol] 28:1–12Google Scholar
  46. Mohr W, Wild A, Wolf HP (1980) Untersuchungen zur Pathogenese der entzündlichen Knorpelzerstörung bei der Adjuvansarthritis der Ratte. Z Rheumatol 39:212–222PubMedGoogle Scholar
  47. Mohr W, Wild A, Wolf HP (1981) Role of polymorphs in inflammatory cartilage destruction in adjuvant arthritis of rats. Ann Rheum Dis 40:171–176PubMedCrossRefGoogle Scholar
  48. Mohrland JS, Johnson EE (1983) Use of the adjuvant-induced arthritic rat model to evaluate non-steroidal anti-inflammatory analgesics. J Pharm Pharmacol 35:40CrossRefGoogle Scholar
  49. Muir VY, Dumonde DC (1982) Different strains of rats develop different clinical forms of adjuvant disease. Ann Rheum Dis 41:538–543PubMedCrossRefGoogle Scholar
  50. Mathur PP, Smyth RD (1980) The relationship between serum gastrin, gastric ulceration and basal acid output in the polyarthritic rat. J Pharmacol Exp Ther 212:333–336PubMedGoogle Scholar
  51. Milhaud G, Labat ML (1978) Thymus and osteopetrosis. Clin Orthop 135:260–271PubMedGoogle Scholar
  52. Milhaud G, Labat ML, Moricard Y (1982) Resistance to adjuvant arthritis induced by a genetic mutation, osteopetrosis. Biomed Pharmacother 36:360–365PubMedGoogle Scholar
  53. Nagao S, Tanaka A (1980) Muramyl dipeptide-induced adjuvant arthritis. Infect Immun 28:624–626PubMedGoogle Scholar
  54. Nakamura H, Shimizu M (1979) Accelerated granuloma formation in adjuvant-induced arthritic rats and its modification by antirheumatic drugs. J Pharmacol Exp Ther 211:20–25PubMedGoogle Scholar
  55. Phadke K (1983) Regulation of metabolism of the chondrocytes in articular cartilage — an hypothesis. J Rheumatol 10:852–860PubMedGoogle Scholar
  56. Phadke K, Fouts R, Parrish JE (1984) Collagen-induced and adjuvant-induced arthritis in rats. Post-immunization treatment with collagen to suppress or abrogate the arthritic response. Arthritis Rheum 27:797–806PubMedGoogle Scholar
  57. Rosenthale ME, Capetola RJ (1982) Adjuvant arthritis: immunopathological and hyperalgesic features. Fed Proc 41:2577–2582PubMedGoogle Scholar
  58. Rooney PJ, Dick WC, Imrie RC, Turner D, Buchanan KD, Ardill J (1978) On the relationship between gastrin, gastric secretion, and adjuvant arthritis in rats. Ann Rheum Dis 37:432–435PubMedCrossRefGoogle Scholar
  59. Schrier D, Gilbertsen RB, Lesch M, Fantone J (1984) The role of neutrophils in type II collagen-induced arthritis in rats. Am J Pathol 117:26–29PubMedGoogle Scholar
  60. Stuart JM, Cremer MA, Dixit SN, Kang AH, Townes AS (1979) Collagen-induced arthritis in rats. Arthritis Rheum 22:347–352PubMedCrossRefGoogle Scholar
  61. Tanaka A, Emori K (1980) Epitheloid granuloma formation by a synthetic bacterial cell wall component, muramyl dipeptide (MDP). Am J Pathol 98:733–748PubMedGoogle Scholar
  62. Trentham DE, McCune WJ, Susman P, David JR (1980) Autoimmunity to collagen in adjuvant arthritis of rats. J Clin Invest 66:1109–1117PubMedCrossRefGoogle Scholar
  63. Van den Berg WB, Kruijsen MWM, van de Putte LBA, van Beusekom HJ. van der Sluis-vander Pol M, Zwarts WA (1981) Antigen-induced and zymosan-induced arthritis in mice: studies on in vivo cartilage proteoglycan synthesis and chondrocyte death. Br J Exp Pathol 62:308–316PubMedGoogle Scholar
  64. Vernon-Roberts B, Liyanage S, Currey HLC (1976) Adjuvant arthritis in the rat. Ann Rheum Dis 35:389–397CrossRefGoogle Scholar
  65. Ward JR, Jones RS (1962) Studies on adjuvant polyarthritis in rats. Arthritis Rheum 5:557–564PubMedCrossRefGoogle Scholar
  66. Welles WL, Battisto JR (1981) Suppression of adjuvant arthritis by antibodies specific for collagen type II. Immunol Commun 10:673–685PubMedGoogle Scholar
  67. Whitehouse WM (1982) Rat polyarthritis: induction with adjuvants constituted with mycobacteria (and oils) from the environment. J Rheumatol 9:494–501PubMedGoogle Scholar
  68. Wild A, Mohr W, Wolf HP (1981) Untersuchungen an 3H-Prolin-vormarkiertem Knorpel bei der Adjuvansarthritis der Ratte. Verh Dtsch Ges Rheumatol 7:469–471Google Scholar
  69. Wilder RL, Allen JB, Wahl LM, Calandra GB, Wahl SM (1983) The pathogenesis of group A streptococcal cell wall-induced polyarthritis in the rat. Comparative studies in arthritis resistant and susceptible inbred rat strains. Arthritis Rheum 26:1442–1451Google Scholar
  70. Wyllie JC (1983) Histopathology of the subchondral bone lesions in rheumatoid arthritis. J Rheumatol 10 [Suppl] 11:26–28Google Scholar

Copyright information

© Dr. Dietrich Steinkopff Verlag, GmbH & Co. KG, Darmstadt 1986

Authors and Affiliations

  • W. Mohr
    • 1
  1. 1.Abteilung PathologieUniversität UlmUlmGermany

Personalised recommendations