Zusammenfassung
Die Adjuvansarthritis der Ratte ist die artikuläre Manifestation der „Adjuvanskrank- heit“, die mit Läsionen in verschiedenen Organen einhergeht. Ihre „Ätiologie“ ist das intradermal oder subkutan injizierte komplette Freundsche Adjuvans (KFA) — ihre vorwiegenden Symptome sind Polyarthritis, Osteomyelitis, Dermatitis, Iridozyklitis, Konjunktivitis, Urethritis, Bronchitis und Pankarditis.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
Anderte SK, Greenblatt JJ, Cromartie WJ, Clark R, Schwab JH (1979) Modulation of the susceptibility of inbred and outbred rats to arthritis induced by cell walls of group A streptococci. Infect Immun 25:484–490
Arumugham R, Bose SM (1980) Glycohydrolases and lysosomal stability in adjuvant induced arthritis. Ital J Biochem 29:27–40
Best R, Christian R, Lewis DA (1984) Effect of particle size of dried mycobacteria on adjuvant induced arthritis in the rat. Agents Actions 14:265–268
Binderup L (1983) Decreased T-suppressor cell activity in rats with adjuvant arthritis. Ann Rheum Dis 42:693–698
Binderup L, Bramm E, Arrigoni-Martelli E (1979) Peritoneal macrophages from adjuvant arthritic rats enhance tumour cell growth in vitro. Experientia 35:1230–1232
Carmichael DJ, Gillard GC, Lowther DA, Handley CJ, Santer VB (1977) Carrageenin-induced arthritis. Arthritis Rheum 20:834–840
Caulfield JP, Hein A, Dynesius-Trentham R, Trentham DE (1982) Morphologic demonstration of two stages in the development of type II collagen-induced arthritis. Lab Invest 46:321–343
Chang YH, Pearson CM, Chedid L (1981) Adjuvant polyarthritis. V. Induction by N-acetyl-muramyl-L-alanyl-D-isoglutamine, the smallest peptide subunit of bacterial peptidoglycan. J ExpMed 153:1021–1026
Clark RL, Cuttino JT, Anderte SK, Cromartie WJ, Schwab JH (1979) Radiologic analysis of arthritis in rats after systemic injection of streptococcal cell walls. Arthritis Rheum 22:25–35
Coffey JW, Salvador RA (1981) Levels of collagenolytic activity, beta-glucuronidase, and collagen prolyl hydroxylase in paws from rats with developing adjuvant arthritis. Biochim Biophys Acta 677:243–252
Collier DH, Kerwar SS, Garovoy MR, Fye KH, Stobo JD (1984) Anticollagen antibodies and immune response gene products in rheumatoid arthritis. Arthritis Rheum 27:1201–1209
Colombo C, Steele RE, Leathern JH, Steinetz BG (1979) An emphysema-like reaction in lungs of adjuvant arthritic rats. Proc Soc Exp Biol Med 161:225–234
Colpaert FC, De Witte P, Maroli AN, Awouters F, Niemegeers CJ, Janssen PA (1980) Self-administration of the analgesic suprofen in arthritic rats: experimental model of chronic pain. Life Sci 27:921–928
Colpaert FC, Meert T, De Witte P, Schmitt P (1982) Further evidence validating adjuvant arthritis as an experimental model of chronic pain in the rat. Life Sci 31:67–75
Dalldorf FG, Cromartie WJ, Anderle SK, Clark RL, Schwab JH (1980) The relation of experimental arthritis to the distribution of streptococcal cell wall fragments. Am J Pathol 100:383–402
DeCastro Costa M, De Sutter P, Gybels J, Van Hees J (1981) Adjuvant-induced arthritis in rats: a possible animal model of chronic pain. Pain 10:173–185
DeLustro F, Carison RP, Datko LJ, De Lustro B, Lewis AJ (1984) The absence of antibodies to type II collagen in established adjuvant arthritis in rats. Agents Actions 14:673–679
DeSimone DP, Parsons DB, Johnson KE, Jacobs RP (1983) Type II collagen-induced arthritis. Arthritis Rheum 26:1245–1258
Dingle JT (1979) Recent studies on the control of joint damage: the contribution of the Strange-ways Research Laboratory. Ann Rheum Dis 38:201–214
Georoeg P, Kovacs IB (1979) Experimental inflammation and tumor growth: chemical carcino-genesis in adjuvant arthritic rats. Inflammation 3:359–364
Gillard GC, Lowther DA (1976) Carrageenin induced arthritis. Arthritis Rheum 19:918–926
Gilman SC, Daniels JF, Wilson RE, Carlson RP, Lewis AJ (1984) Lymphoid abnormalities in rats with adjuvant-induced arthritis. I. Mitogen responsiveness and lymphokine synthesis. Ann Rheum Dis 43:847–855
Henderson B (1984) Increase in the activity of lysosomal acid hydrolases in the chondrocytes of arthritic joints of rabbits with experimental allergic arthritis. Histochem J 16:287–293
Holoshitz J, Matitiau A, Cohen IR (1984) Arthritis induced in rats by cloned T lymphocytes responsive to mycobacteria but not to collagen type II. J Clin Invest 73:211–215
Iizuka Y, Chang YH (1982) Adjuvant polyarthritis. VII. The role of type II collagen in patho-genesis. Arthritis Rheum 25:1325–1332
Kaibara N, Hotokebuchi T, Takagashi K, Katsuki I, Morinaga M, Arita C, Jingushi S (1984) Pathogenetic difference between collagen arthritis and adjuvant arthritis. J Exp Med 159:1388–1396
Kapusta MH, Young-Rodenchuk M, Kourounakis L (1979) Restoration of diminished splenic responses to phytohemagglutinin and concanavalin A in adjuvant-induced disease by virazole: possible pathogenetic role of a virus and suppressor cells. J Rheumatol 6:507–518
Kohashi O, Tanaka A, Kotani S, Shiba T, Kusumoto S, Yokogawa K, Kawata S, Ozawa A (1980) Arthritis-inducing ability of a synthetic adjuvant, N-acetylmuramyl peptides, and bacterial di-saccharide peptides related to different oil vehicles and their composition. Infect Immun 29:70–75
Kohashi O, Pearson CM, Tamaoki N, Tanaka A, Shimamura K, Ozawa A, Kotani S, Saito M, Hioki K (1981) Role of thymus for N-acetylmuramyl-L-alanyl-D-isoglutamine-induced polyarthritis and granuloma formation in euthymic and athymic nude rats or in neonatally thymectomized rats. Infect Immun 31:758–766
Kohashi O, Aihara K, Ozawa A, Kotani S, Azuma I (1982) New model of a synthetic adjuvant. N-acetylmuramyl-L-alanyl-D-isoglutamine-induced arthritis: clinical and histologie studies in athymic nude and euthymic rats. Lab Invest 47:27–36
Kruijsen MWM, van der Berg WB, van de Putte LBA (1983) Damage to chondrocytes: the significance of severity of inflammation. Clin Rheumatol 2:86 (Abstr)
Kuberasampath T, Bose SM (1979) Influence of prednisolone and L-thyroxine on the changes in collagen metabolism in rats with adjuvant-induced arthritis. Agents Actions 9:502–509
Lehman TJA, Allen JB, Plotz PH, Wilder RL (1984) Lactobacillus casei cell wall-induced arthritis in rats: cell wall fragment distribution and persistence in chronic arthritis-susceptible LEW/N and-resistant F344/N rats. Arthritis Rheum 27:939–942
Lussier A, de Medicis R, Tetreault L (1981) Adjuvant arthritis: influence of the adjuvant volume and composition on the non-specific inflammation. Int J Tissue React 3:11–15
Mohr W (1974) Pathologische Anatomie und experimentelle Pathologie rheumatischer Erkrankungen. In: Neuheimer Fortbildungs-Lehrgänge. Band 38: Erworbene Herzfehler — Entzündlicher Rheumatismus. Steinkopff, Darmstadt, S 76–104
Mohr W(1984) Gelenkkrankheiten. Thieme, Stuttgart New York 1984
Mohr W, Wild A (1976 a) Der Ablauf der Adjuvanskrankheit bei Ratten des Stammes AF/Han-EMD-SPF. Z Rheumatol 35:77–90
Mohr W, Wild A (1976 b) Morphologische Untersuchungen an Ratten mit langdauernder Adjuvanskrankheit. Z Rheumatol 35:301–311
Mohr W, Wild A (1976c) Adjuvant arthritis. Arzneim Forsch (Drug Res) 26:1860–1866
Mohr W, Wild A (1977 a) The proliferation of chondrocytes and pannus in adjuvant arthritis. Vir-chows Arch B Cell Pathol 25:1–16
Mohr W, Wild A (1977 b) Autoradiographische Untersuchungen zur Pannusentwicklung bei der Adjuvansarthritis der Ratte. Wien Klin Wochenschr 89:756–765
Mohr W, Wild A, Beneke G (1974) Chronische Osteomyelitis als Manifestation der Adjuvanskrankheit der Ratte. Beitr Pathol 153:1–17
Mohr W, Wild A, Paulini K (1975 a) Proliferation of synovial tissue cells in rats with adjuvant disease. Pathol Microbiol 43:1–9
Mohr W, Hersener J, Wild A, Paulini K (1975 b) Untersuchungen zum Knorpelabbau bei der Adjuvansarthritis der Ratte. Z Rheumatol 34:234–242
Mohr W, Wild A, Wolf HP (1978) Incorporation of 3H-proline into hyaline articular cartilage. Virchows Arch [Cell Pathol] 28:1–12
Mohr W, Wild A, Wolf HP (1980) Untersuchungen zur Pathogenese der entzündlichen Knorpelzerstörung bei der Adjuvansarthritis der Ratte. Z Rheumatol 39:212–222
Mohr W, Wild A, Wolf HP (1981) Role of polymorphs in inflammatory cartilage destruction in adjuvant arthritis of rats. Ann Rheum Dis 40:171–176
Mohrland JS, Johnson EE (1983) Use of the adjuvant-induced arthritic rat model to evaluate non-steroidal anti-inflammatory analgesics. J Pharm Pharmacol 35:40
Muir VY, Dumonde DC (1982) Different strains of rats develop different clinical forms of adjuvant disease. Ann Rheum Dis 41:538–543
Mathur PP, Smyth RD (1980) The relationship between serum gastrin, gastric ulceration and basal acid output in the polyarthritic rat. J Pharmacol Exp Ther 212:333–336
Milhaud G, Labat ML (1978) Thymus and osteopetrosis. Clin Orthop 135:260–271
Milhaud G, Labat ML, Moricard Y (1982) Resistance to adjuvant arthritis induced by a genetic mutation, osteopetrosis. Biomed Pharmacother 36:360–365
Nagao S, Tanaka A (1980) Muramyl dipeptide-induced adjuvant arthritis. Infect Immun 28:624–626
Nakamura H, Shimizu M (1979) Accelerated granuloma formation in adjuvant-induced arthritic rats and its modification by antirheumatic drugs. J Pharmacol Exp Ther 211:20–25
Phadke K (1983) Regulation of metabolism of the chondrocytes in articular cartilage — an hypothesis. J Rheumatol 10:852–860
Phadke K, Fouts R, Parrish JE (1984) Collagen-induced and adjuvant-induced arthritis in rats. Post-immunization treatment with collagen to suppress or abrogate the arthritic response. Arthritis Rheum 27:797–806
Rosenthale ME, Capetola RJ (1982) Adjuvant arthritis: immunopathological and hyperalgesic features. Fed Proc 41:2577–2582
Rooney PJ, Dick WC, Imrie RC, Turner D, Buchanan KD, Ardill J (1978) On the relationship between gastrin, gastric secretion, and adjuvant arthritis in rats. Ann Rheum Dis 37:432–435
Schrier D, Gilbertsen RB, Lesch M, Fantone J (1984) The role of neutrophils in type II collagen-induced arthritis in rats. Am J Pathol 117:26–29
Stuart JM, Cremer MA, Dixit SN, Kang AH, Townes AS (1979) Collagen-induced arthritis in rats. Arthritis Rheum 22:347–352
Tanaka A, Emori K (1980) Epitheloid granuloma formation by a synthetic bacterial cell wall component, muramyl dipeptide (MDP). Am J Pathol 98:733–748
Trentham DE, McCune WJ, Susman P, David JR (1980) Autoimmunity to collagen in adjuvant arthritis of rats. J Clin Invest 66:1109–1117
Van den Berg WB, Kruijsen MWM, van de Putte LBA, van Beusekom HJ. van der Sluis-vander Pol M, Zwarts WA (1981) Antigen-induced and zymosan-induced arthritis in mice: studies on in vivo cartilage proteoglycan synthesis and chondrocyte death. Br J Exp Pathol 62:308–316
Vernon-Roberts B, Liyanage S, Currey HLC (1976) Adjuvant arthritis in the rat. Ann Rheum Dis 35:389–397
Ward JR, Jones RS (1962) Studies on adjuvant polyarthritis in rats. Arthritis Rheum 5:557–564
Welles WL, Battisto JR (1981) Suppression of adjuvant arthritis by antibodies specific for collagen type II. Immunol Commun 10:673–685
Whitehouse WM (1982) Rat polyarthritis: induction with adjuvants constituted with mycobacteria (and oils) from the environment. J Rheumatol 9:494–501
Wild A, Mohr W, Wolf HP (1981) Untersuchungen an 3H-Prolin-vormarkiertem Knorpel bei der Adjuvansarthritis der Ratte. Verh Dtsch Ges Rheumatol 7:469–471
Wilder RL, Allen JB, Wahl LM, Calandra GB, Wahl SM (1983) The pathogenesis of group A streptococcal cell wall-induced polyarthritis in the rat. Comparative studies in arthritis resistant and susceptible inbred rat strains. Arthritis Rheum 26:1442–1451
Wyllie JC (1983) Histopathology of the subchondral bone lesions in rheumatoid arthritis. J Rheumatol 10 [Suppl] 11:26–28
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Dr. Dietrich Steinkopff Verlag, GmbH & Co. KG, Darmstadt
About this paper
Cite this paper
Mohr, W. (1986). Was kann man mit einer Adjuvansarthritis anfangen?. In: Weber, U., Schmidt, K.L. (eds) Experimentelle Rheumatologie. Der Rheumatismus, vol 45. Steinkopff. https://doi.org/10.1007/978-3-642-85356-2_7
Download citation
DOI: https://doi.org/10.1007/978-3-642-85356-2_7
Publisher Name: Steinkopff
Print ISBN: 978-3-7985-0690-9
Online ISBN: 978-3-642-85356-2
eBook Packages: Springer Book Archive