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Experimental allergic arthritis in mice: Factors determining chronicity and tissue destruction

  • Wim B. van den Berg
Part of the Der Rheumatismus book series (2798, volume 45)

Abstract

Chronicity of inflammation can be understood in terms of the continuous presence of an inflammatory stimulus. This may be generated by an abundant supply from the circulation, e.g. through the daily antigenic and bacterial load at the gastrointestinal tract, local retention at special sites, or induction of autoimmune phenomena. Evidence for the importance of local antigen retention in chronicity of joint inflammation has emerged from studies in the antigen induced arthritis model in the rabbit. We have recently found that the principle of local antigen retention is also important for chronicity in the mouse model. Using this latter model evidence was obtained that antigen from the circulation, present either after intravenous or oral administration, may play a role in exacerbations (flare-up) of chronic smouldering arthritis. The present paper summarizes our findings in the antigen induced arthritis model in the mouse, including tissue destruction, factors determining local retention of proteins (antigens) in the joint, and the conditions needed for the occurrence of the flare-up phenomenon.

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References

  1. 1.
    Dumonde DC, Glynn LE (1962) The production of arthritis in rabbits by an immunological reaction to fibrin. Br J Exp Pathol 43:373–383PubMedGoogle Scholar
  2. 2.
    Cooke TD, Hurd ER, Ziff M, Jasin HJ (1972) The pathogenesis of chronic inflammation in experimental antigen induced arthritis II. Preferential localization of antigen-antibody complexes to collagenous tissues. J Exp Med 135:323–338PubMedCrossRefGoogle Scholar
  3. 3.
    Glynn LE (1968) The chronicity of inflammation and its significance in rheumatoid arthritis. Ann Rheum Dis 27:105–121PubMedCrossRefGoogle Scholar
  4. 4.
    Brackertz D, Mitchell GF, Mackay IR (1977) Antigen induced arthritis in mice: Induction of arthritis in various strains of mice. Arthritis Rheum 20:841–850PubMedCrossRefGoogle Scholar
  5. 5.
    van den Berg WB, van Beusekom HJ, van de Putte LBA, Zwarts WA, van der Sluis M (1982) Antigen handling in antigen induced arthritis in mice. An autoradiographic and im-munofluorescence study using whole joint sections. Am J Pathol 108:9–16PubMedGoogle Scholar
  6. 6.
    Kruijsen MWM, van den Berg WB, van de Putte LBA, van den Broek WJM (1981) Detection and quantification of experimental joint inflammation in mice by measurement of 99mTc-per-technetate uptake. Agents Actions 11:640–642PubMedCrossRefGoogle Scholar
  7. 7.
    Lens JW, van den Berg WB, van de Putte LBA (1984) Quantification of arthritis by 99mTc-up-take measurements in the mouse knee joint: correlation with histological joint inflammation scores. Agents Actions 14:723–728PubMedCrossRefGoogle Scholar
  8. 8.
    Kruijsen MWM, van den Berg WB, van de Putte LBA (1983) Sequential alterations of peri-articular structures in antigen induced arthritis in mice: Histological observations on fibrous capsule, ligaments, bone and muscles, using whole joint sections. Br J Exp Pathol 64:298–305PubMedGoogle Scholar
  9. 9.
    Schalkwijk J, van den Berg WB, van de Putte LBA, Loosten LAB, van der Sluis M (1985) Effects of experimental joint inflammation on bone marrow and periarticular bone. A study of two types of arthritis, using variable degrees of inflammation. Br J Exp Pathol 66:435–444PubMedGoogle Scholar
  10. 10.
    van den Berg WB, Kruijsen MWM, van de Putte LBA, van Beusekon HJ, van der Sluis M, Zwarts WA (1981) Antigen induced arthritis in mice: studies on in vivo cartilage proteoglycan synthesis and chondrocyte death. Br J Exp Pathol 62:308–316PubMedGoogle Scholar
  11. 11.
    van den Berg WB, Kruijsen MWM, van de Putte LBA (1982) The mouse patella assay: an easy method of quantitating articular cartilage function in vivo and in vitro. Rheumatol Int 1:165–169CrossRefGoogle Scholar
  12. 12.
    Kruijsen MWM, van den Berg WB, van de Putte LBA (1985) Significance of severity and duration of murine antigen induced arthritis for cartilage proteoglycan synthesis and chondrocyte death. Arthritis Rheum 28:813–819PubMedCrossRefGoogle Scholar
  13. 13.
    Kruijsen MWM, van de Putte LBA, van den Berg WB (1984) Chondrocyte impairment: Another mechanism of cartilage destruction in chronic arthritis. Agents Actions 14:143–152CrossRefGoogle Scholar
  14. 14.
    van den Berg WB, Schalkwijk J, Kruijsen MWM, van de Putte LBA (1985) Influence of chronic allergic joint inflammation on hyaline articular cartilage. Advances in Inflammation research. Vol 10. Proceedings III Int Congress of Inflammation. Raven PressGoogle Scholar
  15. 15.
    Schalkwijk J, van den Berg WB, van de Putte LBA, Joosten LAB (1985) Hydrogen peroxide suppresses the proteoglycan synthesis of intact articular cartilage. J Rheumatol 12:205–210PubMedGoogle Scholar
  16. 16.
    van den Berg WB, van de Putte LBA, Zqqrts WA, Joosten LAB (1984) Electrical charge of the antigen determines intraarticular antigen handling and chronicity of arthritis in mice. J Clin Invest 74:1850–1859PubMedCrossRefGoogle Scholar
  17. 17.
    van den Berg WB, van de Putte LBA (1985) Electrical charge of the antigen determines its localization in the mouse knee joint: deep penetration of cationic BSA in hyaline articular cartilage. Am J Pathol 121:224–234PubMedGoogle Scholar
  18. 18.
    Maroudas A. Physicochemical properties of articular cartilage. In: Freeman MAR (ed) Adult articular cartilage, 2nd ed. Pitman Medical Publ, London, p 215Google Scholar
  19. 19.
    Schalkwijk J, van den Berg WB, van de Putte LBA, Joosten LAB, van den Bersselaar L (1985) Cationization of catalase, peroxidase, and Superoxide dismutase. Effect of improved intraarticular retention on experimental arthritis in mice. J Clin Invest 76:198–205PubMedCrossRefGoogle Scholar
  20. 20.
    Lens JW, van den Berg WB, van de Putte LBA (1984) Flare up of antigen induced arthritis in mice after challenge with intravenous antigen: studies on the characteristics of and the mechanisms involved in the reaction. Clin Exp Immunol 55:287–294PubMedGoogle Scholar
  21. 21.
    van de Putte LBA, Lens JW, van den Berg WB, Kruijsen MWM (1983) Exacerbation of antigen induced arthritis after challenge with intravenous antigen. Immunology 49:161–167PubMedGoogle Scholar
  22. 22.
    Lens JW, van den Berg WB, van de Putte LBA, van den Bersselaar L (1984) Flare up of antigen induced arthritis in mice after challenge with oral antigen. Clin Exp Immunol 58:364–371PubMedGoogle Scholar
  23. 23.
    Lens JW, van den Berg WB, van de Putte LBA, Berden JHM, Lems SPM (1984) Flare up of antigen induced arthritis in mice after challenge with intravenous antigen: effects of pretreatment with cobra venom factor and anti-lymphocyte serum. Clin Exp Immunol 57:520–528PubMedGoogle Scholar
  24. 24.
    van den Berg WB, Lens JW, van de Putte LBA, van Beusekom HJ (1982) Antigen induced arthritis: Antigen handling and chronicity of joint inflammation. Agents Actions [Suppl] 11:233–241Google Scholar

Copyright information

© Dr. Dietrich Steinkopff Verlag, GmbH & Co. KG, Darmstadt 1986

Authors and Affiliations

  • Wim B. van den Berg
    • 1
  1. 1.Department of RheumatologyUniversity Hospital, St. RadboudNijmegen GAThe Netherlands

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