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Experimental allergic arthritis in mice: Factors determining chronicity and tissue destruction

  • Conference paper
Experimentelle Rheumatologie

Part of the book series: Der Rheumatismus ((2798,volume 45))

Abstract

Chronicity of inflammation can be understood in terms of the continuous presence of an inflammatory stimulus. This may be generated by an abundant supply from the circulation, e.g. through the daily antigenic and bacterial load at the gastrointestinal tract, local retention at special sites, or induction of autoimmune phenomena. Evidence for the importance of local antigen retention in chronicity of joint inflammation has emerged from studies in the antigen induced arthritis model in the rabbit. We have recently found that the principle of local antigen retention is also important for chronicity in the mouse model. Using this latter model evidence was obtained that antigen from the circulation, present either after intravenous or oral administration, may play a role in exacerbations (flare-up) of chronic smouldering arthritis. The present paper summarizes our findings in the antigen induced arthritis model in the mouse, including tissue destruction, factors determining local retention of proteins (antigens) in the joint, and the conditions needed for the occurrence of the flare-up phenomenon.

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Author information

Authors and Affiliations

  1. Department of Rheumatology, University Hospital, St. Radboud, Geert Grooteplein Zuid 8, 6525, Nijmegen GA, The Netherlands

    Dr. Wim B. van den Berg

Authors
  1. Dr. Wim B. van den Berg
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Editor information

Editors and Affiliations

  1. Med. Zentrum für Orthopädie, Klinikum der Justus-Liebig-Universität, Paul-Meimberg-Str. 3, 6300, Gießen, Germany

    U. Weber

  2. Klinik für physikalische Medizin, Balneologie und Rheumatologie der Universität Gießen, Ludwigstraße 37-39, 6350, Bad Nauheim, Germany

    K. L. Schmidt

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© 1986 Dr. Dietrich Steinkopff Verlag, GmbH & Co. KG, Darmstadt

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van den Berg, W.B. (1986). Experimental allergic arthritis in mice: Factors determining chronicity and tissue destruction. In: Weber, U., Schmidt, K.L. (eds) Experimentelle Rheumatologie. Der Rheumatismus, vol 45. Steinkopff. https://doi.org/10.1007/978-3-642-85356-2_6

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  • DOI: https://doi.org/10.1007/978-3-642-85356-2_6

  • Publisher Name: Steinkopff

  • Print ISBN: 978-3-7985-0690-9

  • Online ISBN: 978-3-642-85356-2

  • eBook Packages: Springer Book Archive

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