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Über den Einfluß von Kortikoiden (Betamethason) aufZellen und Matrix von hyalinem Gelenkknorpel — eine ultrastrukturelle Untersuchung

  • W. Noack
  • H. Mellerowicz
Conference paper
Part of the Der Rheumatismus book series (2798, volume 45)

Zusammenfassung

Kortikoide finden bei der Therapie von primären Synovialitiden aber auch besonders bei der Behandlung der aktivierten Arthrose in der Praxis eine breite Anwendung. Ziel der Behandlung ist die Entzündungsunterdrückung und damit die Reduzierung von aktivierten Enzymen im Gelenkinnenraum, welche die Knorpelmatrix abbauen können.

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Literatur

  1. Annefeld M (1984) Die Bedeutung des Chondrozyten für die Erhaltung der Integrität des Gelenkknorpels. Akt Rheumatol 9 (Sonderheft 1):37–45CrossRefGoogle Scholar
  2. Annefeld M, Raiss R (1984) Veränderungen in der Ultrastruktur des Chondrozyten unter dem Einfluß eines GAG-Peptid-Komplexes. Akt Rheumatol 9 (Sonderheft 2):99–104CrossRefGoogle Scholar
  3. Balch HW, Gibson JMC, El-Ghobarey AF, Bain LS, Lynch MP (1977) Repeated corticosteroid injections into knee joints. Rheumatol Rehabil 16:137–140PubMedCrossRefGoogle Scholar
  4. Barker WD, Martinek J (1976) An Ultrastructural Evaluation of the effect of hydrocortisone on rabbit cartilage. Clin Orthop 115:286–290PubMedGoogle Scholar
  5. Baxter JD, Forsham PH (1972) Tissue Effects of Glucocorticoids. Am J Med 53:575–589CrossRefGoogle Scholar
  6. Behrens F, Shephard N, Mitchell N (1975) Alteration of Rabbit articular cartilage by intra-articu-lar injections of Glucocorticoids. J Bone Joint Surg 57:70–76PubMedGoogle Scholar
  7. Behrens F, Shepard N, Mitchell N (1976) Metabolic recovery of articular cartilage after intra-articular injections of glucocorticoids. J Bone Joint Surg 58 A: 1157Google Scholar
  8. Bentley G, Goodfellow JW (1969) Disorganisation of the knees following intra-articular hydrocortisone injections. J Bone Joint Surg (Br) 51:498–502Google Scholar
  9. Bondy PK (1969) The Adrenal Cortex. In: Bondy PK, Duncan’s Diseases of Metabolism. Ed. 6, Philadelphia, SaundersGoogle Scholar
  10. Boström H, Odeblad E (1953) The Influence of Corticoids Upon the Sulphate Exchange of Chon-droitin Sulphuric Acid. Arkiv Kemi 6:39Google Scholar
  11. Chandler GN, Wright V (1958) Deleterious effect of intra-articular-hydrocortisone. Lancet 11:661–663CrossRefGoogle Scholar
  12. Chretien JH, Garagusi VF (1972) Corticosteroid effect on phagocytosis and NBT reduction by human polymorphonuclear neutrophils. J Reticuloendothel Soc 11:358PubMedGoogle Scholar
  13. Denko CW, Bergenstal D-M (1961) Effects of Hormone and Corticosteroids on S35 Fixation in Cartilage. Endocrinology 69:769–777PubMedCrossRefGoogle Scholar
  14. Gibson T, Burry HC, Poswillo D, Glass J (1976) Effect of Intra-Articular-Corticosteroid Injections on Primate Cartilage. Ann Rheumatol Dis 36:74–79CrossRefGoogle Scholar
  15. Gray R, Gottlieb NL (1983) Intraarticular Corticosteroids. Clin Orthop 177:235–261PubMedGoogle Scholar
  16. Hamilton JA, Bootes A, Phillips PE, Seywka J (1981) Human synovial fibroblast plasminogen activator. Modulation of enzyme activity by antiinflammatory steroids. Artheritis Rheum 24:1296–1309Google Scholar
  17. Higuchi M, Masuda T, Susnda K, Ishii S, Abe K (1980) Ultrastructure of the Articular Cartilage after Systemic Administration of Hydrocortisone in the Rabbit. Clin Orthop 152:296–302PubMedGoogle Scholar
  18. Holder AT, Preece MA, Wallis M (1981) Effect of glucocorticoids, butanol extraction of serum and adrenalectomy on somatomedin levels in the rat. J Endocrinol 90:(3) 411–420PubMedCrossRefGoogle Scholar
  19. Hollander JL, Jessar RA, Brown EM Jr (1961) Intra-Synovial Corticosteroid Therapy. A Decade of Use. Bull Rheumatol Dis 11:239–240Google Scholar
  20. Jacoby RK (1976) The Effect of Hydrocortisone Acetate on Adult Human Articular Cartilage. J Rheumatol 3:384–389PubMedGoogle Scholar
  21. Kalbhen DA (1983) Können Kortikosteroide und nicht-steroidale Antirheumatika Arthrosen induzieren oder fördern? Therapiewoche 33:2597–2603Google Scholar
  22. Layton LL (1951) Cortisone Inhibition of Mucopolysaccaride Synthesis in the Intact Rat. Arch Biochem Biophys 32:224PubMedCrossRefGoogle Scholar
  23. Lewis DA, Day EH (1972) Biochemical Factors in the Action of Steroids on Diseased Joints in Rheumatoid Arthritis. Ann Rheum Dis 31:374–378PubMedCrossRefGoogle Scholar
  24. Mankin HJ, Conger KA (1966) The Acute Effects of Intra-Articular Cartilage in Rabbits. J Bone Joint Sure [Am] 48:1383–1388Google Scholar
  25. McGuire MKB, Meats JE, Ebsworth NM (1982) Messenger function of prostaglandins in cell to cell interaction and control of proteinase activity in the rheumatoid joint. Int J Immunopharma-col 4(2):91–102CrossRefGoogle Scholar
  26. Noack W, Groher W (1980) Elektronenmikroskopische Untersuchung über experimentell erzeugte Gelenkinstabilität bei Kaninchen. In: Jäger M, Hackenbroch MH, Refior HJ (Hrsg) Osteosyn-these, Endoprothetik und Biomechanik der Gelenke. Thieme, Stuttgart, S 144–150Google Scholar
  27. Noack W (1981) Tierexperimentelle und in vitro Untersuchungen über die Heilung unterschiedlich tiefer Knorpeldefekte in Abhängigkeit vom Alter und unter dem Einfluß von GAGs. Habilitationsschrift FU BerlinGoogle Scholar
  28. Oikarinen A (1977) Effect of cortisol acetate on collagen biosynthesis and on the activities of prolyl hydroxylase, lysyl hydroxylase, collagen galactosyltransferase and glucosyltransferase in chickembryo tendon cells. Biochem J 164:533–539PubMedGoogle Scholar
  29. Puhl W, Dustmann HO, Quosdrof U (1973) Tierexperimentelle Untersuchungen zur Regeneration des Gelenkknorpels. Unfallchir 74:352CrossRefGoogle Scholar
  30. Puhl W, Dustmann HO (1976) Die intraartikuläre medikamentöse Therapie der posttraumatischen Arthrose. Unfallheilkunde 128:118–129Google Scholar
  31. Salter RB, Gross Allan, Hall JH (1967) Hydrocortisone Arthropathy — An Experimental Investigation. Can Med Ass J 97:374–377PubMedGoogle Scholar
  32. Sandritter W, Beneke G (1974) Allgemeine Pathologie. Schattauer Stuttgart New YorkGoogle Scholar
  33. Shaw NE, Lacey E (1973) The influence of corticosteroids on normal and papain-treated articular cartilage in the rabbit. J Bone and Joint Surg 55 B: 197–205Google Scholar
  34. Silberberg M, Silberberg R, Hasler M (1966) Fine structure of articular cartilage in mice receiving cortisone acetate. Arch Pathol 82:596Google Scholar
  35. Steinberg J, Tsukamoto S, Sledge CB (1979) A tissue culture model of cartilage breakdown in rheumatoid arthritis. III. Effects of antirheumatic drugs. Arthritis Rheum 22/8:877–885CrossRefGoogle Scholar
  36. Thomas L (1964) The Effects of Papain, Vitamin A, and Cortisone on Cartilage Matrix in Vivo. Biophy [Suppl] 4:207CrossRefGoogle Scholar
  37. Wassilev W, Owtscharov W (1972) Veränderungen am Gelenkknorpel nach Einwirkung von Hy-drocortison. Arch Orthop Unfallchir 72:21–27PubMedCrossRefGoogle Scholar
  38. Weissmann G (1969) The effects of steroids and drugs on lysosomes, Lysosomes in Biology and Pathology, Vol. 1. Edited by JT Dingle, HB Fell. Amsterdam, North Holland Publishing Co. pp 276–295Google Scholar

Copyright information

© Dr. Dietrich Steinkopff Verlag, GmbH & Co. KG, Darmstadt 1986

Authors and Affiliations

  • W. Noack
    • 1
  • H. Mellerowicz
    • 1
  1. 1.Leitender Oberarzt im RKU Orthopädische KlinikUniversität UlmUlm/DonauGermany

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