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Immunkomplexe fehlen an der mit Granulozyten infiltrierten subchondralen Pannus-Knorpel-Grenze bei der chronischen Polyarthritis

  • H. Menninger
  • W. Mohr
  • D. Wessinghage
Conference paper
Part of the Der Rheumatismus book series (2798, volume 45)

Zusammenfassung

Bei der chronischen Polyarthritis (CP) wird der Oberflächenpannus gemeinhin als jenes Gewebe betrachtet, das den Gelenkknorpel zerstört. Dabei sollen nach Fassbender in einem nichtentzündlichen Prozeß unreif aussehende synoviale tumorartige Zellen („mesenchymoide Transformation“) für die Knorpelresorption verantwortlich sein (1,2). Untersuchungsbefunde anderer Autoren unterstreichen jedoch die entzündliche Natur des destruktiven Gelenkprozesses, da makrophagen- und fibroblastenartige Zellen (3, 4), Mastzellen (5, 6) und neutrophile Granulozyten (7-9) in der Grenzzone zwischen Knorpel und Pannus beschrieben werden.

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Literatur

  1. 1.
    Fassbender HG (1984) Is pannus a residue of inflammation? (Letter) Arthritis Rheum 27:956–957PubMedCrossRefGoogle Scholar
  2. 2.
    Fassbender HG, Simmhng-Annefeld M (1983) The potential aggressiveness of synovial tissue in rheumatoid arthritis. J Pathol 139:399–406PubMedCrossRefGoogle Scholar
  3. 3.
    Shiozawa S, Shiozawa K, Fujita T (1983) Morphologic observations in the early phase of the cartilage-pannus junction. Light and electron microscopic studies of active cellular pannus. Arthritis Rheum 26:472–478Google Scholar
  4. 4.
    Shiozawa S (1984) Process of cartilage destruction by the pannus in rheumatoid arthritis. (Letter) Arthritis Rheum 27:957CrossRefGoogle Scholar
  5. 5.
    Bromley M, Fisher WD, Wooley DE (1984) Mast cells at sites of cartilage erosion in the rheumatoid joint. Ann Rheum Dis 43:76–79PubMedCrossRefGoogle Scholar
  6. 6.
    Bromley M, Woolley E (1984) Histopathology of the rheumatoid lesion. Identification of cell types at sites of cartilage erosion. Arthritis Rheum 27:857–863PubMedCrossRefGoogle Scholar
  7. 7.
    Mohr W, Wessinghage D (1977) The relationship between polymorphonuclear granulocytes and cartilage destruction in rheumatoid arthritis. Z Rheumatol 36:316–331PubMedGoogle Scholar
  8. 8.
    Mohr W, Menninger H (1980) Polymorphonuclear granulocytes at the pannus-cartilage junction in rheumatoid arthritis (Letter). Arthritis Rheum 23:1413–1414PubMedCrossRefGoogle Scholar
  9. 9.
    Mohr W (1984) Gelenkkrankheiten: Diagnostik und Pathogenese makroskopischer und histo-logischer Strukturveränderungen. Thieme, StuttgartGoogle Scholar
  10. 10.
    Ishikawa H, Smiley JD, Ziff M (1975) Electron microscopic demonstration of immunoglobulin deposition in rheumatoid cartilage. Arthritis Rheum 18:563–576PubMedCrossRefGoogle Scholar
  11. 11.
    Ugai K, Ziff M, Jasin HE (1979) Interaction of polymorphonuclear Leukozytes with Immune Complexes Trapped in Joint Collagenous Tissues, Arthritis Rheum 22:353–364PubMedCrossRefGoogle Scholar
  12. 12.
    Ugai K, Ishikawa H, Hirohata K, Shirane H (1983) Interaction of polymorphonuclear leukocytes with immune complexes trapped in rheumatoid articular cartilage. Arthritis Rheum 26:1434–1441PubMedCrossRefGoogle Scholar
  13. 13.
    Cooke TD, Hurd ER, Jasin HE, Bienenstock J, Ziff M, (1975) Identification of immunoglobulins and complement in rheumatoid articular collagenous tissues. Arthritis Rheum 18:541–551PubMedCrossRefGoogle Scholar
  14. 14.
    Ohno O, Cooke TD (1978) Electron microscopic morphology of immunoglobulin aggregates and their interactions in rheumatoid articular collagenous tissues. Arthritis Rheum 21:516–527PubMedCrossRefGoogle Scholar
  15. 15.
    Shiozawa S, Jasin HE, Ziff M (1980) Absence of immunoglobulins in rheumatoid cartilage-pannus junction. Arthritis Rheum 23:816–821PubMedCrossRefGoogle Scholar
  16. 16.
    Jasin HE (1985) Autoantibody specificities of immunecomplexes sequestered in articular cartilage of patients with rheumatoid arthritis and osteoarthritis. Arthritis Rheum 28:241–248PubMedCrossRefGoogle Scholar
  17. 17.
    Cooke TDV, Sumia M, Elliott S, Maeda M (1983) Immunecomplex mediated destruction of cartilage in antigen-induced arthritis of rabbits. J Rheumatol [Suppl] 11:103–107Google Scholar
  18. 18.
    Uehlinger E (1974) Skelettveränderungen bei entzündlich-rheumatischen Erkrankungen vom pathologisch-anatomischen Standpunkt. Z Rheumatol 33:157–162Google Scholar
  19. 19.
    Barrie HJ (1981) Histologic changes in rheumatoid disease of the metacarpal and metatarsal heads as seen in surgical material. J Rheumatol 8:246–257PubMedGoogle Scholar
  20. 20.
    Wyllie JC (1983) Histopathology of the subchondral bone lesion in rheumatoid arthritis. J Rheumatol [Suppl] 11:26–28Google Scholar
  21. 21.
    Bromley M, Wooley DE (1984) Chondroclasts and Osteoclasts at Subchondral Sites of Erosion in the Rheumatoid Joint. Arthritis Rheum 27:968–975PubMedCrossRefGoogle Scholar
  22. 22.
    Menninger H, Lambusch M, Mohr W, Wessinghage D (1983) Immunkomplexe: Mediatoren für die Bildung von entzündlichem Granulationsgewebe? Immunhistologische Untersuchungen am hyalinen Gelenkknorpel bei chronischer Polyarthritis. Z Rheumatol 42:7–15PubMedGoogle Scholar
  23. 23.
    Menninger H, Lambusch M, Mohr W, Wessinghage D, Hoos R (1983) Immunkomplexe im hyalinen Gelenkknorpel? Immunhistologische Untersuchungen bei der chronischen Polyarthritis. In: Dettmer N, Lindner J, Kleesiek K, Mohr W, Puhl W (Hrsg) Theoretische und klinische Befunde der Knorpelforschung. III. Symposium für Bindegewebsforschung Bad Waldsee. Eular, Basel, S 102–110Google Scholar
  24. 24.
    Menninger H, Putzier R, Mohr W, Wessinghage D, Tillmann K (1980) Granulocyte elastase at the site of cartilage erosion by rheumatoid synovial tissue. Z Rheumatol 39:145–156PubMedGoogle Scholar
  25. 25.
    Taylor CR, Burns J (1974) The demonstration of plasma cells and other immunoglobulin containing cells in formalin-fixed and paraffin-embedded tissues using peroxidase labelled antibody. J Clin Pathol 27:14–20PubMedCrossRefGoogle Scholar
  26. 26.
    Velvart M, Fehr K, Baici A, Sommermeyer G, Knöpfel M, Cancer M, Salgam P, Böni A (1981) Degradation in vivo of Articular Cartilage in Rheumatoid Arthritis by Leucocyte Elastase from Polymorphonuclear Leucocytes. Rheumatol Int 1:121–130PubMedCrossRefGoogle Scholar
  27. 27.
    Schmalz F, Braunsteiner H (1968) Cytochemische Darstellung von Esteraseaktivität in Blut-und Knochenmarkszellen. Klin Wschr 46:642–650CrossRefGoogle Scholar
  28. 28.
    Rosenberg L (1971) Chemical basis for the histological use of safranin-0 in study of articular cartilage. J Bone Jt Surg 53A:69–82Google Scholar
  29. 29.
    Janis R, Hamerman D (1969) Articular cartilage changes in early arthritis. Bull Hosp Joint Dis 30:136–152PubMedGoogle Scholar
  30. 30.
    Bassis M (1974) Necrotaxis: Chemotaxis towards an Injured Cell. Antibiotics Chemother 19:369–381Google Scholar
  31. 31.
    Dingle JT (1979) Heberden oration 1978. Recent studies on the control of joint damage: the contribution of the Strangeway Research Laboratory. Ann Rheum Dis 38:201–214Google Scholar
  32. 32.
    Menninger H, Burkhardt H, Röske W, Ehlebracht W, Gurr E, Mohr W, Mierau HD (1981) Lysosomal Elastase: Effect on Mechanical and Biochemical Properties of Normal Cartilage, Inhibition by Polysulfonated Glycosaminoglycan, and Binding to Chondrocytes. Rheumatol Int 1:73–81PubMedCrossRefGoogle Scholar
  33. 33.
    Menninger H, Mohr W, Mierau HD (1981) Granulozytenelastase, ein Schlüsselenzym bei der rheumatischen Knorpeldestruktion. In: Otte R, Wagenhäuser FJ (Hrsg) Fortschritte der Rheumatologie. Steinkopff, Darmstadt, S 550–554Google Scholar
  34. 34.
    Burkhardt H, Schwingel M, Menninger H, MacCartney HW, Tschesche H: Oxygen Radicals as Effectors of Cartilage Destruction: Direct Degradative Effect on Matrix Components and Indirect Action via Activation of Latent Collagenase from Polymorphonuclear Leukocytes. Arthritis and Rheumatism (in press)Google Scholar
  35. 35.
    Bates EJ, Lowther DA, Handley CJ (1984) Oxygen free-radicals mediate an inhibition of pro-teoglycan synthesis in cultured articular cartilage. Ann Rheum Dis 43:462–469PubMedCrossRefGoogle Scholar
  36. 36.
    Bartholomew JS, Lowther DA, Handley CJ (1984) Changes in Proteoglycan Biosynthesis Following Leukocyte Elastase Treatment of Bovine Articular Cartilage in Culture. Arthritis Rheum 27:905–912PubMedCrossRefGoogle Scholar

Copyright information

© Dr. Dietrich Steinkopff Verlag, GmbH & Co. KG, Darmstadt 1986

Authors and Affiliations

  • H. Menninger
    • 1
  • W. Mohr
    • 2
  • D. Wessinghage
    • 1
  1. 1.Rheuma-Zentrum des Bayerischen Roten KreuzesBad AbbachGermany
  2. 2.Universität UlmBad AbbachGermany

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