Wirkung von Teopranitol auf den Tonus perfundierter Arterien und Venen in vitro

  • R. Busse
  • U. Pohl
  • E. Bassenge
Conference paper


Die vasodilatatorische Potenz des neu entwickelten organischen Nitrats Teopranitol (KC 046 = 2-(γ Theophyllin-7-ylpropylamino)-2-desoxy-L-isoidid-5-nitrat Bifumarat) wurde in den letzten drei Jahren in klinischen Studien wie auch in experimentellen In-vivo-und In-vitro-Untersuchungen dokumentiert (2).


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Bassenge E, Holtz J, Pohl U (1984) Wirkungen von Teopranitol (KC 046) auf das venöse System und das Koronarsystem am wachen Hund. In: Bender F, Gerlaeh E (eds) Therapie der Angina pectoris mit Teopranitol. Steinkopff Darmstadt, S25–33Google Scholar
  2. 2.
    Bender F, Gerlach E (eds) (1984) Therapie der Angina pectoris mit Teopranitol. Steinkopff DarmstadtGoogle Scholar
  3. 3.
    Biamino G (1982) Vergleichende Untersuchungen über die Wirkung von Molsidomin, organischen Nitraten und Calciumantagonisten auf die glatte Gefäßmuskulatur. In: Bassenge E, Schmutzler H (eds) Molsidomin: Neue Aspekte zur Therapie der ischämischen Herzerkrankung. Urban & Schwarzenberg, München, S47–55Google Scholar
  4. 4.
    Busse R, Trogisch G, Bassenge E (1985) The role of endothelium in the control of vascular tone. Basis Res Cardiol 80:475–490CrossRefGoogle Scholar
  5. 5.
    Cauvin C, Lukeman S, Cameron J, Hwang O, van Breemen C (1985) Differences in norepinephrine activation and diltiazem inhibition of calcium channels in isolated rabbit aorta and mesenteric resistance vessels. Circ Res 56:822–828PubMedGoogle Scholar
  6. 6.
    Cauvin C, Saida K, van Breemen C (1984) Extracellular Ca2+ dependence and diltiazem inhibition of contraction in rabbit conduit arteries and mesenteric resistance vessels. Blood Vessels 21:23–31PubMedGoogle Scholar
  7. 7.
    Delaflotte S, Auguet M, DeFeudis FV, Baranes J, Clostre F, Drieu K, Braquet P (1984) Endothelium-dependent relaxations of rabbit isolated aorta produced by carbachol and by ginkgo biloba extract. Biomed Biochim Acta 43:S212–216PubMedGoogle Scholar
  8. 8.
    Fiscus RR, Torphy TJ, Mayer SE (1984) Cyclic GMP-dependent protein kinase activation in canine tracheal smooth muscle by methacholine and sodium nitroprusside. Biochim Biophys Acta 805:382–392PubMedCrossRefGoogle Scholar
  9. 9.
    Förstermann U, Hertting G, Neufang B (1984) The importance of endogenous prostaglandins other than prostacyclin, for the modulation of contractility of some rabbit blood vessels. Br J Pharmac 81:623–630Google Scholar
  10. 10.
    Furchgott RF (1983) Role of endothelium in responses of vascular smooth muscle. Circ Res 53:557–573PubMedGoogle Scholar
  11. 11.
    Gabard B, Chatterjee SS, Klessing K (1984) Pharmakologie von Teopranitol (KC 046), einer neuen antianginösen Substanz. In: Bender F, Gerlach E (eds) Therapie der Angina pectoris mit Teopranitol. Steinkopff Darmstadt, Sl–16Google Scholar
  12. 12.
    Goodman FR, Adams HR, Weiss GB (1975) Effects of neomycin on 45 Ca binding and distribution in canine arteries. Blood Vessels 12:248–260PubMedGoogle Scholar
  13. 13.
    Griffith TM (1985) Studies of endothelium-derived relaxant factor (EDRF), its nature and mode of action. Eur Heart J 6:37–49PubMedGoogle Scholar
  14. 14.
    Hardman JG (1984) Cyclic nucleotides and regulation of vascular smooth muscle. J Cardiovasc Pharmacol 6:S639–S645PubMedCrossRefGoogle Scholar
  15. 15.
    Hickey KA, Rubanyi G, Paul RJ, Highsmith RF (1985) Characterization of a coronary vasoconstrictor produced by cultured endothelial cells. Am J Physiol 248:C550–C556PubMedGoogle Scholar
  16. 16.
    Ignarro LJ, Kadowitz PJ (1985) The pharmacological and physiological role of cyclic GMP in vascular smooth muscle relaxation. Ann Rev Pharmacol Toxicol 25:171–191CrossRefGoogle Scholar
  17. 17.
    Karaki H, Nakagawa H, Urakawa N (1985) Age-related changes in the sensitivity to verapamil and sodium nitroprusside of vascular smooth muscle of rabbit aorta. Br J Pharmac 85:223–228Google Scholar
  18. 18.
    Lincoln TM, Johnson RM (1984) Possible role of eyclic-GMP-dependent protein kinase in vascular smooth muscle fonction. In: Greengard P (ed) Advances in cyclic nucleotide and protein phosphorylation research. Vol 17; Raven Press, New York, p 285–296Google Scholar
  19. 19.
    Morgan JP, Morgan KG (1984) Stimulus-specific patterns of intracellular calcium levels in smooth muscle of ferret portal vein. J Physiol 351:156–167Google Scholar
  20. 20.
    Peach MJ, Loeb AL, Singer HA, Saye J (1985) Endothelium-derived vascular relaxing factor. Hypertension 7(S I):1–94-1-100Google Scholar
  21. 21.
    Poole JCF, Sanders AG, Florey UW (1958) The regeneration of aortic endothelium. J Path Bact 75:133–143PubMedCrossRefGoogle Scholar
  22. 22.
    Popescu LM, Panoiu C, Hinescu M, Nutu O (1985) The mechanism of cGMP-induced relaxation in vascular smooth muscle. Eur J Pharmacol 107:393–394PubMedCrossRefGoogle Scholar
  23. 23.
    Rapoport RM, Murad F (1983) Endothelium-dependent and nitrovasodilator-induced relaxation of vascular smooth muscle: Role of cyclic GMP. J Cyclic Nucleotide Res 9:281–296Google Scholar
  24. 24.
    Rapoport RM, Schwartz K, Murad F (1985) Effect of sodium-potassium pump inhibitors and membrane-depolarizing agents on sodium nitroprusside-induced relaxation and cyclic guanosine monophosphate accumulation in rat aorta. Circ Res 57:164–171PubMedGoogle Scholar
  25. 25.
    Rubanyi G, Vanhoutte PM (1985) Endothelium-removal decreases relaxations of canine coronary arteries caused by β-adrenergic agonists and adenosine. J Cardiovasc Pharmacol 7:139–144PubMedCrossRefGoogle Scholar
  26. 26.
    Rubanyi GM, Vanhoutte PM (1985) Hypoxia releases a vasoconstrictor substance from the canine vascular endothelium. J Physiol 364:45–56PubMedGoogle Scholar
  27. 27.
    Sato M, Ohashi M, Metz MZ, Bing RJ (1982) Inhibitory effect of a calcium antagonist (Diltiazem) on aortic and coronary contractions in rabbits. J Mol Cell Cardiol 14:741–744PubMedCrossRefGoogle Scholar
  28. 28.
    Schrör K, Weiss P, Darius H (1984) Wirkung von Teopranitol (KC 046) auf Koronargefäßtonus und Prostacyclinbildung in vitro im Vergleich zu anderen organischen Nitraten. In: Bender F, Gerlach E (eds) Therapie der Angina pectoris mit Teopranitol. Steinkopff Darmstadt, S41–48Google Scholar
  29. 29.
    van Breemen C, Farinas BR, Gerba P, McNaughton ED (1972) Excitation-contraction coupling in rabbit aorta. Studied by the lanthanum method for measuring cellular calcium influx. Circ Res 30:44–54PubMedGoogle Scholar

Copyright information

© Dr. Dietrich Steinkopff Verlag, GmbH & Co. KG, Darmstadt 1986

Authors and Affiliations

  • R. Busse
    • 1
  • U. Pohl
  • E. Bassenge
  1. 1.Lehrstuhl für angewandte PhysiologieFreiburg i. Br.Deutschland

Personalised recommendations