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Wirkung von Teopranitol auf den Tonus perfundierter Arterien und Venen in vitro

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Book cover Therapie der koronaren Herzkrankheit mit Teopranitol

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Zusammenfassung

Die vasodilatatorische Potenz des neu entwickelten organischen Nitrats Teopranitol (KC 046 = 2-(γ Theophyllin-7-ylpropylamino)-2-desoxy-L-isoidid-5-nitrat Bifumarat) wurde in den letzten drei Jahren in klinischen Studien wie auch in experimentellen In-vivo-und In-vitro-Untersuchungen dokumentiert (2).

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Literatur

  1. Bassenge E, Holtz J, Pohl U (1984) Wirkungen von Teopranitol (KC 046) auf das venöse System und das Koronarsystem am wachen Hund. In: Bender F, Gerlaeh E (eds) Therapie der Angina pectoris mit Teopranitol. Steinkopff Darmstadt, S25–33

    Google Scholar 

  2. Bender F, Gerlach E (eds) (1984) Therapie der Angina pectoris mit Teopranitol. Steinkopff Darmstadt

    Google Scholar 

  3. Biamino G (1982) Vergleichende Untersuchungen über die Wirkung von Molsidomin, organischen Nitraten und Calciumantagonisten auf die glatte Gefäßmuskulatur. In: Bassenge E, Schmutzler H (eds) Molsidomin: Neue Aspekte zur Therapie der ischämischen Herzerkrankung. Urban & Schwarzenberg, München, S47–55

    Google Scholar 

  4. Busse R, Trogisch G, Bassenge E (1985) The role of endothelium in the control of vascular tone. Basis Res Cardiol 80:475–490

    Article  CAS  Google Scholar 

  5. Cauvin C, Lukeman S, Cameron J, Hwang O, van Breemen C (1985) Differences in norepinephrine activation and diltiazem inhibition of calcium channels in isolated rabbit aorta and mesenteric resistance vessels. Circ Res 56:822–828

    PubMed  CAS  Google Scholar 

  6. Cauvin C, Saida K, van Breemen C (1984) Extracellular Ca2+ dependence and diltiazem inhibition of contraction in rabbit conduit arteries and mesenteric resistance vessels. Blood Vessels 21:23–31

    PubMed  CAS  Google Scholar 

  7. Delaflotte S, Auguet M, DeFeudis FV, Baranes J, Clostre F, Drieu K, Braquet P (1984) Endothelium-dependent relaxations of rabbit isolated aorta produced by carbachol and by ginkgo biloba extract. Biomed Biochim Acta 43:S212–216

    PubMed  CAS  Google Scholar 

  8. Fiscus RR, Torphy TJ, Mayer SE (1984) Cyclic GMP-dependent protein kinase activation in canine tracheal smooth muscle by methacholine and sodium nitroprusside. Biochim Biophys Acta 805:382–392

    Article  PubMed  CAS  Google Scholar 

  9. Förstermann U, Hertting G, Neufang B (1984) The importance of endogenous prostaglandins other than prostacyclin, for the modulation of contractility of some rabbit blood vessels. Br J Pharmac 81:623–630

    Google Scholar 

  10. Furchgott RF (1983) Role of endothelium in responses of vascular smooth muscle. Circ Res 53:557–573

    PubMed  CAS  Google Scholar 

  11. Gabard B, Chatterjee SS, Klessing K (1984) Pharmakologie von Teopranitol (KC 046), einer neuen antianginösen Substanz. In: Bender F, Gerlach E (eds) Therapie der Angina pectoris mit Teopranitol. Steinkopff Darmstadt, Sl–16

    Google Scholar 

  12. Goodman FR, Adams HR, Weiss GB (1975) Effects of neomycin on 45 Ca binding and distribution in canine arteries. Blood Vessels 12:248–260

    PubMed  CAS  Google Scholar 

  13. Griffith TM (1985) Studies of endothelium-derived relaxant factor (EDRF), its nature and mode of action. Eur Heart J 6:37–49

    PubMed  CAS  Google Scholar 

  14. Hardman JG (1984) Cyclic nucleotides and regulation of vascular smooth muscle. J Cardiovasc Pharmacol 6:S639–S645

    Article  PubMed  Google Scholar 

  15. Hickey KA, Rubanyi G, Paul RJ, Highsmith RF (1985) Characterization of a coronary vasoconstrictor produced by cultured endothelial cells. Am J Physiol 248:C550–C556

    PubMed  CAS  Google Scholar 

  16. Ignarro LJ, Kadowitz PJ (1985) The pharmacological and physiological role of cyclic GMP in vascular smooth muscle relaxation. Ann Rev Pharmacol Toxicol 25:171–191

    Article  CAS  Google Scholar 

  17. Karaki H, Nakagawa H, Urakawa N (1985) Age-related changes in the sensitivity to verapamil and sodium nitroprusside of vascular smooth muscle of rabbit aorta. Br J Pharmac 85:223–228

    CAS  Google Scholar 

  18. Lincoln TM, Johnson RM (1984) Possible role of eyclic-GMP-dependent protein kinase in vascular smooth muscle fonction. In: Greengard P (ed) Advances in cyclic nucleotide and protein phosphorylation research. Vol 17; Raven Press, New York, p 285–296

    Google Scholar 

  19. Morgan JP, Morgan KG (1984) Stimulus-specific patterns of intracellular calcium levels in smooth muscle of ferret portal vein. J Physiol 351:156–167

    Google Scholar 

  20. Peach MJ, Loeb AL, Singer HA, Saye J (1985) Endothelium-derived vascular relaxing factor. Hypertension 7(S I):1–94-1-100

    Google Scholar 

  21. Poole JCF, Sanders AG, Florey UW (1958) The regeneration of aortic endothelium. J Path Bact 75:133–143

    Article  PubMed  CAS  Google Scholar 

  22. Popescu LM, Panoiu C, Hinescu M, Nutu O (1985) The mechanism of cGMP-induced relaxation in vascular smooth muscle. Eur J Pharmacol 107:393–394

    Article  PubMed  CAS  Google Scholar 

  23. Rapoport RM, Murad F (1983) Endothelium-dependent and nitrovasodilator-induced relaxation of vascular smooth muscle: Role of cyclic GMP. J Cyclic Nucleotide Res 9:281–296

    CAS  Google Scholar 

  24. Rapoport RM, Schwartz K, Murad F (1985) Effect of sodium-potassium pump inhibitors and membrane-depolarizing agents on sodium nitroprusside-induced relaxation and cyclic guanosine monophosphate accumulation in rat aorta. Circ Res 57:164–171

    PubMed  CAS  Google Scholar 

  25. Rubanyi G, Vanhoutte PM (1985) Endothelium-removal decreases relaxations of canine coronary arteries caused by β-adrenergic agonists and adenosine. J Cardiovasc Pharmacol 7:139–144

    Article  PubMed  CAS  Google Scholar 

  26. Rubanyi GM, Vanhoutte PM (1985) Hypoxia releases a vasoconstrictor substance from the canine vascular endothelium. J Physiol 364:45–56

    PubMed  CAS  Google Scholar 

  27. Sato M, Ohashi M, Metz MZ, Bing RJ (1982) Inhibitory effect of a calcium antagonist (Diltiazem) on aortic and coronary contractions in rabbits. J Mol Cell Cardiol 14:741–744

    Article  PubMed  CAS  Google Scholar 

  28. Schrör K, Weiss P, Darius H (1984) Wirkung von Teopranitol (KC 046) auf Koronargefäßtonus und Prostacyclinbildung in vitro im Vergleich zu anderen organischen Nitraten. In: Bender F, Gerlach E (eds) Therapie der Angina pectoris mit Teopranitol. Steinkopff Darmstadt, S41–48

    Google Scholar 

  29. van Breemen C, Farinas BR, Gerba P, McNaughton ED (1972) Excitation-contraction coupling in rabbit aorta. Studied by the lanthanum method for measuring cellular calcium influx. Circ Res 30:44–54

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Lehrstuhl für angewandte Physiologie, Hermann-Herder-Straße 7, 7800, Freiburg i. Br., Deutschland

    Prof. Dr. R. Busse

Authors
  1. Prof. Dr. R. Busse
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  2. U. Pohl
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  3. E. Bassenge
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© 1986 Dr. Dietrich Steinkopff Verlag, GmbH & Co. KG, Darmstadt

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Busse, R., Pohl, U., Bassenge, E. (1986). Wirkung von Teopranitol auf den Tonus perfundierter Arterien und Venen in vitro. In: Therapie der koronaren Herzkrankheit mit Teopranitol. Steinkopff. https://doi.org/10.1007/978-3-642-85355-5_4

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  • DOI: https://doi.org/10.1007/978-3-642-85355-5_4

  • Publisher Name: Steinkopff

  • Print ISBN: 978-3-7985-0683-1

  • Online ISBN: 978-3-642-85355-5

  • eBook Packages: Springer Book Archive

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