Use of centrally-acting agonists in the treatment of mild hypertension in the elderly patient

  • J. I. M. Drayer
  • M. A. Weber
Conference paper

Abstract

The treatment of patients with mild hypertension has created considerable interest in recent years. The availability of many potent antihypertensive agents allows blood pressure to be effectively controlled without major adverse effects. It is believed that control of even mild elevations of blood pressure significantly reduces the incidence of major cardiovascular complications.

Keywords

Obesity Beach Noradrenaline Catecholamine Propranolol 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Ashraf N, Locksley R, Arieff AI (1981) Thiazide-induced hyponatraemia associated with death or neurologic damage in outpatients. Am J Med 70: 1163–1168.PubMedCrossRefGoogle Scholar
  2. 2.
    Barrett-Connor E, Criqui MH, Klauber MR, Holdbrook M (1981) Diabetes and hypertension in a community of older adults. Am J Epidemiol 113: 276–284.Google Scholar
  3. 3.
    Beretta-Piccoli C, Davies DL, Boddy K et al (1982) Relation of arterial pressure with body sodium, body potassium and plasma potassium in essential hypertension. Clin Sci 63: 257–270.PubMedGoogle Scholar
  4. 4.
    Bühler FR, Burkart F, Lütold BE, Küng M, Marbet G, Pfisterer M (1975) Antihypertensive beta-blocking action as related to renin and age: a pharmacologic tool to identify pathogenetic mechanisms in essential hypertension. Am J Cardiol 36: 653–669.PubMedCrossRefGoogle Scholar
  5. 5.
    Bühler FR, Kiowski W, Landmann R et al. (1982) Changing role of beta-and alpha-adrenoreceptor-mediated cardiovascular responses in the transition from high-cardiac output into a high-peripheral resistance phase in essential hypertension. In: Largh JH, Bühler F, Seldin D (Eds.) Frontiers in Hypertension Research, Springer-Verlag, New York, 316–326.Google Scholar
  6. 6.
    Drayer JIM, Weber MA, Laragh JH, Sealey JE (1982) Renin subgroups in essential hypertension. Clin Exp Hypertens A4: 1817–1834.CrossRefGoogle Scholar
  7. 7.
    Drayer JIM, Weber MA, Sealey JE, Laragh JH (1981) Low and high renin essential hypertension: a comparison of clinical and biochemical characteristics. Am J Med Sci 281: 135–142.PubMedCrossRefGoogle Scholar
  8. 8.
    Drayer JIM, Weber MA, Sealey JE, Laragh JH (submitted for publication 1983 ). Comparison of clinical characteristics of patients with systolic and diastolic hypertension.Google Scholar
  9. 9.
    Kannel WB (1974) Role of blood pressure in cardiovascular morbidity and mortality. Prog Cardiovasc Dis 17: 5–24.PubMedCrossRefGoogle Scholar
  10. 10.
    Kannel WB, Dawber TR, McGee DL (1980) Perspectives on systolic hypertension. The Framingham Study. Circulation 61: 1179–1182.PubMedGoogle Scholar
  11. 11.
    Kannel WB, Gordon T, Castelli WP, Margolis JR (1970) Electrocardiographic left ventricular hypertrophy and risk of coronary heart disease. The Framingham Study. Ann Intern Med 72: 813–822.PubMedGoogle Scholar
  12. 12.
    Messerli FH, Gerald MD, Dreslinski GR (1981 b) Antiadrenergic therapy: special aspects in hypertension in the elderly. Hypertension 3 (Suppl II ): 226–239.Google Scholar
  13. 13.
    Messerli FH, Glade LB, Dreslinski GR et al (1981 a) Hypertension in the elderly: haemodynamic, fluid volume and endocrine findings. Clin Sci 61: 393s - 394s.Google Scholar
  14. 14.
    Multiple Risk Factor Intervention Trial Research Group (1982) Multiple risk factor intervention trial. Risk factor changes and mortality, results. JAMA 2481: 1465–1477.CrossRefGoogle Scholar
  15. 15.
    Niarchos AP (1980) Pathophysiology, diagnosis, and treatment of hypertension in the elderly. Cardiovasc Rev Rep 1: 621–627.Google Scholar
  16. 16.
    Norwegian Multicenter Study Group (1981) Timolol-induced reduction in mortality and re-infarction in patients surviving acute myocardial infarction. N Engl J Med 304: 801–807.CrossRefGoogle Scholar
  17. 17.
    Palmer GJ, Ziegler MG, Lake CR (1978) Response of norepinephrine and blood pressure to stress increases with age. J Gerontol 33: 482–487.PubMedGoogle Scholar
  18. 18.
    Schocken DD, Roth GS (1977) Reduced beta-adrenergic receptor concentrations in aging man. Nature 267: 856–865.PubMedCrossRefGoogle Scholar
  19. 19.
    Stebbins PT, Taylor GJ, Gibson RS, Beller GA (1980) Risk factors and myocardial infarction in the elderly. Circulation 62 (Suppl III): 220–230.Google Scholar
  20. 20.
    Thananopavarn C, Golub MS, Sambhi MP (1983) Clonidine in the elderly hypertensive. Monotherapy and therapy with a diuretic. Chest 2 (Suppl): 410–411.Google Scholar
  21. 21.
    Weber MA, Drayer JIM, Gray DR (1983) Combined diuretic and sympatholytic therapy in elderly patients with predominant systolic hypertension. Chest 2 (Suppl): 416–419.Google Scholar

Copyright information

© Dr. Dietrich Steinkopff Verlag, GmbH & Co. KG, Darmstadt 1984

Authors and Affiliations

  • J. I. M. Drayer
    • 1
  • M. A. Weber
  1. 1.Hypertension Center WI30VA Medical CenterLong BeachUSA

Personalised recommendations