Dissociation of hypertrophy and altered function in senescent rat myocardium

  • E. G. Lakatta


In the rat aging model functional and biochemical alterations of senescence are accompanied by myocardial hypertrophy. The studies described herein indicate that this hypertrophy (1) does not involve a concomitant alteration in myofibrillar ATPase activity, (2) is not the cause of prolonged contraction times, i.e., time-to-peak force and relaxation time observed in the senescent heart.

Key words

adult aging rat myocardium isometric contraction isolated cardiac muscle myofibrillar ATPase cardiac hypertrophy chronic exercise 


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Copyright information

© Dr. Dietrich Steinkopff Verlag, GmbH & Co. KG, Darmstadt 1983

Authors and Affiliations

  • E. G. Lakatta
    • 1
  1. 1.Gerontology Research Center, National Institute on AgingNational Institutes of HealthBaltimore, MarylandUSA

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