Effect of aortic constriction on rat heart function and mortality

  • H.-G. Zimmer
Conference paper

Summary

The maximal rate of rise of left ventricular pressure (LV dP/dtmax) measured in closed-chest rats by means of an ultraminiature catheter pressure transducer served as an indicator of cardiac contractility (6). It was slightly increased subsequent to constriction of the abdominal aorta and markedly enhanced after administration of isoproterenol and triiodothyronine. In all three models of cardiac hypertrophy, the enhancement of contractility occurred prior to the maximal stimulation of myocardial adenine nucleotide and protein synthesis. Combination of severe aortic constriction with simultaneous administration of isoproterenol induced an impairment of rat heart function. 24 hours after this intervention, heart rate, left ventricular systolic pressure, and LV dP/dtmax were all depressed by more than 20 %, and the content of cardiac ATP was also diminished to about the same extent. The mortality of rats with severe aortic constriction, which was 46 % when physiologic saline was applied as continuous i.v. infusion for 48 hours, was reduced to 18 % by ribose.

Key words

adenine nucleotide biosynthesis afterload cardiac ATP content cardiac contractility cardioprotection isoproterenol triiodothyronine 

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Copyright information

© Dr. Dietrich Steinkopff Verlag, GmbH & Co. KG, Darmstadt 1983

Authors and Affiliations

  • H.-G. Zimmer
    • 1
  1. 1.Physiologisches Institut der UniversitätMünchen 2Germany

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