Effects of activity on some physiological properties of skeletal muscles

  • G. Vrbová
Conference paper


The mechanism by which the motor nerve exerts its influence on some contractile and biochemical properties of skeletal muscle were discussed. Evidence to show that the contractile and biochemical characteristics of skeletal muscle are determined by the particular pattern of activity that is imposed upon the muscle by its motor nerve is presented- Each motoneurone can in this way induce in the muscle fibres it supplies the development of those properties that will match its particular activity pattern.

Key words

skeletal muscle activity contractile and biochemical properties 


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  1. Amphlett, G. W., S. V. Perry, H. Syska, M. Brown, G. Vrbová: Cross innervation and the regulatory protein system of rabbit soleus muscle. Nature 257, 602–604 (1975).PubMedCrossRefGoogle Scholar
  2. Bárány M.: ATP-ase activity of myosin correlated with speed of muscle shortening. J. Gen. Physiol. 50, (suppl. part 2), 197–218 (1967).PubMedCrossRefGoogle Scholar
  3. Bárány, M., R. I. Close: The transformation of myosin in cross-innervated rat muscles. J. Physiol. 213, 455–474 (1971).PubMedGoogle Scholar
  4. Brown, M. D., M. A. Cotter, O. Hudlická, G. Vrbová: The effects of different patterns of muscle activity on capillary density, mechanical properties and structure of slow and fast rabbit muscles. Pflügers Arch. 361, 241–250 (1976).PubMedCrossRefGoogle Scholar
  5. Buller, A. J., J. C. Eccles, R. M. Eccles: Interactions between motoneurones and muscles in respect of the characteristic speeds of their responses. J. Physiol. 150, 417–139 (1960).PubMedGoogle Scholar
  6. Buller, A. J., W. F. H. M. Mommaerts, K. Seraydarian: Enzymic properties of myosin in fast and slow twitch muscles of the cat following cross-innervation. J. Physiol. 205, 581–597 (1969).PubMedGoogle Scholar
  7. Cooper, S., J. C. Eccles: The isometric responses of mammalian muscles. J. Physiol. 69, 377–385 (1930).PubMedGoogle Scholar
  8. Denny-Brown, D.: The histological features of striped muscle in relation to its functional activity. Proc. R. Soc. 104, 371–411 (1929).CrossRefGoogle Scholar
  9. Dhoot, G. K., S. V. Perry, G. Vrbová: Changes in distribution of the components of the troponin complex in muscle fibres after cross-innervation. Exp. Neurol. 72, 513–530 (1981).PubMedCrossRefGoogle Scholar
  10. Eccles, J. C, R. M. Eccles, A. Lundberg: The action potentials of motoneurones supplying fast and slow muscles. J. Physiol. 142, 272–291 (1958).Google Scholar
  11. Pette, D., W. Müller, E. Leisner, G. Vrbová: Time dependent effects on contractile properties, fibre population, myosin light chains and enzymes of energy metabolism in intermittent and continuously stimulated fast twitch muscle of the rabbit. Pflügers. Arch. 364, 103–112 (1976).PubMedCrossRefGoogle Scholar
  12. Pette, D., M. E. Smith, H. W. Staudte, G. Vrbová: Effects of long-term electrical stimulation on some contractile and metabolic characteristics of fast rabbit muscles. Pflügers Arch. 338, 257–272 (1973).PubMedCrossRefGoogle Scholar
  13. Ramirez, B. U., D. Pette: Effects of long-term electrical stimulation on sarcoplasmic reticulum of fast rabbit muscle. Febs. Lett. 49, 188–190 (1975).CrossRefGoogle Scholar
  14. Ranvier, L.: De quelques faits relatifs à l’histologie et à la physiologie des muscles striés. Archives of Physiological and Normal Pathology 6, 1–5 (1974).Google Scholar
  15. Riley, D. A., E. F. Allin: The effects of inactivity programmed stimulation, and denervation on the histochemistry of skeletal muscle fibre types. Experimental Neurology 40, 391–413 (1973).PubMedCrossRefGoogle Scholar
  16. Romanul, F. C. A., J. P. van der Meulen: Slow and fast muscles after cross innervation. Enzymatic and physiological changes. Arch. Neurol. 17, 387–402 (1967).Google Scholar
  17. Salmons, S., G. Vrbová: The influence of activity on some contractile characteristics of mammalian fast and slow muscles. J. Physiol. 201, 535–549 (1969).PubMedGoogle Scholar
  18. Sperry, R. W.: The problem of central nervous reorganisation after regeneration and muscle transposition. Quart. Rev. Biol. 20, 311–369 (1945).PubMedCrossRefGoogle Scholar
  19. Streter, F. A., J. Gergely, S. Salmons, F. Romanul: Synthesis by fast muscle of myosin light chains characteristic of slow muscle in response to long term stimulation. Nature New Biology, 214, 17–19 (1973).Google Scholar
  20. Vrbová, G.: Changes in motor reflexes produced by tenotomy. J. Physiol. 166, 241–250 (1963a).PubMedGoogle Scholar
  21. Vrbová, G.: The effect of motoneurone activity on the contraction speed of striated muscle. J. Physiol. 169, 513–526 (1963b).PubMedGoogle Scholar
  22. Vrbová, G.: Factors determining the speed of contraction of striated muscle. J. Physiol. 185, 17–18P (1966).Google Scholar
  23. Weeds, A. G., D. R. Trentham, C. J. C. Kean, A. J. Buller: Myosin from cross-innervated cat muscles. Nature. 247, 135–139 (1974).PubMedCrossRefGoogle Scholar

Copyright information

© Dr. Dietrich Steinkopff Verlag, GmbH & Co. KG, Darmstadt 1983

Authors and Affiliations

  • G. Vrbová
    • 1
  1. 1.Dept. of Anatomy and Embryology and Centre for NeuroscienceUniv. College LondonLondonUK

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