Development of Tolerance and Peripheral Hemodynamic Effects of Molsidomine

  • H. Kaiser
  • G. Sold
  • J. Schrader
  • H. Kreuzer
Conference paper


With increasing use of vasoactive substances in the treatment of patients with coronary artery disease, with and without angina pectoris, with and without congestive heart failure, one must consider the possibility that, as a result of different mechanisms, tolerance to the desired hemodynamic effects of these substances may occur. Indeed, in the case of nitrates there is increasing evidence that tolerance at least to some of these effects may develop (1): for example, isosorbide dinitrate given chronically leads to significantly lesser changes in heart rate, blood pressure, and exercise-induced ST deviations than occur with a single dose (2). However, the clinical significance of tolerance to singular effects is unclear; at present there are no convincing reports that tolerance extends to patients with congestive heart failure and to antianginal effects (3).


Systolic Blood Pressure Single Dose Vasoactive Substance Isosorbide Dinitrate Nitrate Tolerance 
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Copyright information

© Dr. Dietrich Steinkopff Verlag, GmbH & Co. KG, Darmstadt 1983

Authors and Affiliations

  • H. Kaiser
    • 1
  • G. Sold
  • J. Schrader
  • H. Kreuzer
  1. 1.Medizinische Klinik und PoliklinikUniversität GöttingenGöttingenGermany

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