Relation Between Urate Transport and Tubular Flow Rate in Rat and Man

  • P. Deetjen
  • F. Lang
  • R. Greger
Conference paper
Part of the Fortschritte der Urologie und Nephrologie/Advances in Urology and Nephrology book series (2824, volume 16)


Fractional excretion of urate in man follows a distinct circadian rhythm. This rhythm is monophasic and normally parallels that of urine flow rate (Fig. 1). However, if urine flow rate is enhanced by excessive drinking of tap water, there is no concomittant increase of urate excretion (6). On the other hand, if osmotic diuresis is induced by the infusion of mannitol, uric acid excretion increases significantly (Fig. 2).


Uric Acid Proximal Tubule Fractional Excretion Urine Flow Rate Uric Acid Excretion 
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Copyright information

© Dr. Dietrich Steinkopff Verlag, GmbH & Co. KG, Darmstadt 1981

Authors and Affiliations

  • P. Deetjen
    • 1
  • F. Lang
    • 1
  • R. Greger
    • 1
  1. 1.Institute of PhysiologyUniversity of InnsbruckInnsbruckAustria

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