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β2-Microglobulin Excretion in Patients with Uric Acid Stones

  • K.-H. Bichler
  • S. Korn
  • I. Lämmert
  • A. Haußmann
Conference paper
Part of the Fortschritte der Urologie und Nephrologie/Advances in Urology and Nephrology book series (2824, volume 16)

Abstract

For the pathogenesis of urine acid lithiasis, tubular defects must be considered. These defects are possibly connected with changed urine acidity and enzymatic defects. Our own previous examinations of patients with uric acid stones showed a significant decrease of uromucoid excretion, a fact, which we would like to interpret as an alteration in the tubular region. In this connection the question arises whether patients with uric acid lithiasis have proteinuria resulting from a tubular insufficiency. Tubular defects can lead to typical proteinuria, especially the excretion of ß2-microglobulin (Wibell). Its determination in the urine is suitable for the diagnosis of the tubular proteinuria.

Keywords

Uric Acid Calcium Oxalate Urinary Stone Uric Acid Stone Uric Acid Excretion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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  3. B. MacArdle: A modified method for the micro-determination of citrate Biochem. J. 60: 647 (1955).Google Scholar
  4. A. Knappwost, S. Gerlach: Zur Methodik der Zitratbestimmung im Harn. In: Pathogenese und Klinik der Harnsteine. V.G. Gasser and W. Vahlensieck ed. Steinkoff, Darmstadt, 1977.Google Scholar
  5. L. Wibell: Studies of 32-microglobulin in human serum, ure and amniotic fluid. Doctoral Thesis at Uppsala University (1974).Google Scholar

Copyright information

© Dr. Dietrich Steinkopff Verlag, GmbH & Co. KG, Darmstadt 1981

Authors and Affiliations

  • K.-H. Bichler
    • 1
  • S. Korn
    • 1
  • I. Lämmert
    • 1
  • A. Haußmann
    • 1
  1. 1.Department of UrologyUniversity of TübingenTübingenWest Germany

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