β2-Microglobulin Excretion in Patients with Uric Acid Stones
For the pathogenesis of urine acid lithiasis, tubular defects must be considered. These defects are possibly connected with changed urine acidity and enzymatic defects. Our own previous examinations of patients with uric acid stones showed a significant decrease of uromucoid excretion, a fact, which we would like to interpret as an alteration in the tubular region. In this connection the question arises whether patients with uric acid lithiasis have proteinuria resulting from a tubular insufficiency. Tubular defects can lead to typical proteinuria, especially the excretion of ß2-microglobulin (Wibell). Its determination in the urine is suitable for the diagnosis of the tubular proteinuria.
KeywordsFiltration Creatinine Citrate Acidity Oxalate
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