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Makrophagen und Makrophagenprodukte in der Pathogenese der Gelenkdestruktion bei der chronischen Polyarthritis

  • R. Dreher
Part of the Rheumatologische Grundlagenforschung book series (RHEGRU)

Zusammenfassung

Im Organismus ubiqutär vorkommende mesenchymale Makrophagen zeichnen sich durch ihre hohe Phagozytosefähigkeit aus und wurden von Aschoff 1913 (1) als retikuloendotheliales Zellsystem (RES) bezeichnet, ein Konzept, welches von Thomas 1949 (2) durch den Begriff des retikulo-histiozytären Systems (RHS) bestätigt und von Langevoort, Cohn, Hirsch,Humphrey, Spector und v. Furth 1970 (3) durch den Begriff des Mononuclear-Phagocyte-System (MPS) entsprechend zellkinetischer Erkenntnis neu klassiflziert wurde. Hiernach handelt es sich bei dem MPS um ein Zellsystem welches sich von den Promonozyten des Knochenmarks und den Blutmonozyten ableitet. Nach dem Auswandern der zirkulierenden Monozyten in das Gewebe differenzieren sich dieselben unter dem Einfluß von zellulären und humoral en Interaktionen zu Gewebsmakrophagen.

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Copyright information

© Dr. Dietrich Steinkopff Verlag GmbH & Co. KG, Darmstadt 1981

Authors and Affiliations

  • R. Dreher
    • 1
  1. 1.Zentrum Innere Medizin, Medizinische Universitäts-PoliklinikJustus-Liebig-UniversitätGießenDeutschland

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