Advertisement

Antikörper, Immunkomplexe und Komplement: ihre Interaktion in der Pathogenese der Gelenkdestruktion bei chronischer Polyarthritis

  • K. Fehr
  • M. Velvart
  • A. Baici
  • M. Knöpfel
  • G. Sommermeyer
  • P. Salgam
  • G. Cohen
  • A. Böni
Part of the Rheumatologische Grundlagenforschung book series (RHEGRU)

Zusammenfassung

Seit den klassischen Arbeiten von Smiley et al. (l) und Pekin und Zvaifler(2) wissen wir, daß in der Synovialis von Patienten mit chronischer Polyarthritis (cP) große Mengen von Immunglobulin G-, A- und M (IgG, IgA, IgM) synthetisiert werden (Tabelle 1). Die Quantität der dabei in vitro gebildeten Immunglobuline – gemessen auf Gewichtsbasis - gleicht bzw. ist größer als die Menge, welche in der Milz bzw. in den Lymphknoten derselben Patienten synthetisiert wird.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. 1.
    Smiley, J., Sachs, c., Zitt, M.: In vitro synthesis of immunoglobulin by rheumatoid synovial membrane J. clin. Invest. 47, 624 (1968).Google Scholar
  2. 2.
    Sliwinski, A.J., Zvaifier, N.J.: In vivo synthesis of IgG by rheumatoid synovium. J. Lab. clin: Med. 76, 304 (1970).Google Scholar
  3. 3.
    Munthe, E., Natvig, J.B.: Complement-fixing intracellular complexes of IgG rheumatoid factor in rheumatoid plasma cells. Scand. J. Immuno!. 1, 217 (1972).CrossRefGoogle Scholar
  4. 4.
    Natvig, J.B., Munthe, E.: Self-associating rheumatoid factor represents a major response of plasma cells in rheumatoid inflammatory tissue. Ann. N. Y. Acad. Sci. 256, 88 (1975).PubMedCrossRefGoogle Scholar
  5. 5.
    Munthe, E.: Complexes of IgG and IgG rheumatoid factor in synovial tissues of juvenile rheumatoid arthritis. Scand. J. Rheumato!. 1, 153 (1972).CrossRefGoogle Scholar
  6. 6.
    Nowoslawski, A., Brzoska, W.J.: Immunopathology of rheumatoid arthritis. I. The rheumatoid synovitis. Path. europ. 2, 198 (1967).Google Scholar
  7. 7..
    Fehr, K., Velvart, M, Rauber, M, Knopfel, M, Baici, A., Salgam, P., Bani, A.: Production of agglutinators and rheumatoid factors in plasma cells of rheumatoid and non-rheumatoid synovial tissues. Arthritis Rheum. 1981. 1m Druck.Google Scholar
  8. 8.
    Steffen, e.: Relationship between collagen immunology and pathogenesis of rheumatoid arthritis. In: Milller, W., Harwerth, H.·G., Fehr, K., (Editors): Rheumatoid Arthritis, Colloquia Geigy, Proc. Int. Symp. Basle 1971, p. 411 (Academic Press, London/ New York 1971).Google Scholar
  9. 9.
    Wiik, A., Jensen, E., Friis, 1.: Granulocyte-specific antinuclear factors in synovial fluids and sera from patients with rheumatoid arthritis. Ann. rheum. Dis. 33, 515 (1974).PubMedCrossRefGoogle Scholar
  10. 10.
    Mellbye, O.J., Munthe, E.: Specific binding of immunoconglutinin in tissues and synovial fluids from patients with rheumatoid arthritis. Clin. Expo Immunol. 8, 713 (1971).Google Scholar
  11. 11.
    Fehr, K.: Immunologie und Immunpathologie chronischer Synovitiden. In: Polyarthritiden. Proc. Int. Symp. Torremolinos 1975, hrsg. von F.J. Wagenhiiuser, p. 113 (Huber, Bern/Stuttgart/Wien 1976).Google Scholar
  12. 12.
    Rodman, W.S., Williams, R.e., Bilka, P.J., Milller· Eberhard, H. J.: Immunofluorescent localization of the third and the fourth component of complement in synovial tissue from patients with rheumatoid arthritis. J. Lab. clin. Med. 69,141 (1967).PubMedGoogle Scholar
  13. 13.
    Bonomo, L., Tursi, A., Gillardi, u.: Distribution of the anti-gammaglobulin factors in the synovial membrane and other tissues in various diseases. Ann. rheum. Dis. 27, 122 (1968).PubMedCrossRefGoogle Scholar
  14. 14.
    Tursi, A., Trizio, D., Bonomo, L.: An immunofluorescence mixed staining technique for the detection of IgG-rheumatoid factor and IgG-iJ I C complexes in tissues. CIin. expo Immunol. 6, 767 (1970).Google Scholar
  15. 15.
    Munthe, E., Natvig, J.B.: Characterization of IgG complexes in eluates from rheumatoid tissue. Clin. expo Immunol. 8, 249 (1971).Google Scholar
  16. 16.
    Winchester, R.J., Agnello, V., Kunkel, H. G.: Gammaglobulin complexes in synovial fluid of patients wifll rheumatoid arthritis. Partial characterization and relationship to lowered complement levels. Clin. expo Immunol. 6, 689 (1970).Google Scholar
  17. 17.
    Perrin, L.H., Nydegger, U.E., Zubler, R.H., Lam· bert, P.H., Miescher, P.A.: Correlation between levels of breakdown products of C3, C4 and properdin factor B in synovial fluids from patients with rheumatoid arthritis. Arthritis Rheum. 20, 647(1977).Google Scholar
  18. 18.
    Nydegger, u.E., Zubler, R.H., Gabay, R., Jolliat, G., Karagevrekis, Ch., Lambert, PH., Miescher, P.A.: Circulating complement breackdown products in patients with rheumatoid arthritis. Correlation between plasma C 3 d, circulating immune complexes and clinical activity. J. din. Invest. 59, 862 (1977).Google Scholar
  19. 19..
    Raitt, I.M.: Mitteilung vom 23.1l.1978 anläßlich „International Symposium on the Immunopathogenesis of Rheumatoid Arthritis“, Guy’s Hospital, London.Google Scholar
  20. 20.
    Hayashi, H.: Chemotaxis in immune tissue injury. In: Allergology, Proc. VIII Int. Congress Allergolgy Tokyo 1973, edit. by Y. Yamamura et aI., p. 252 (Excerpta Medica 1974).Google Scholar
  21. 21.
    Barrett, A. 1.: The possible role of neutrophil proteinases in damage to articular cartilage. Agents and Actions, 8, 11 (1978).PubMedCrossRefGoogle Scholar
  22. 22.
    Hollingsworth, J. W., Siegel, E.K. and Creasey, W.A.: Granulocyte survival in synovial exudate of patients with rheumatoid arthritis and other inflammatory joint diseases. Yale J. BioI. Med. 39, 289 (1967).Google Scholar
  23. 23.
    Starkey, P.M, Barrett, A.1. and Burleigh, Me.: The degradation of articular collagen by neutrophil proteinases. Biochim. Biophys. Acta (1977).Google Scholar
  24. 24.
    Fehr, K., Baici, A., Velvart, M., Knopfel, M, Rauber, M., Sommermeyer, G., Salgam, P., Cohen, G., Bani, A.: Die chronische Polyarthritis: Rolle der polymorphkernigen Leukozyten bei der Zerstorung von Pannus-freiem Knorpel. Bull. Schweiz. Akad. Med. Wiss. 35, 317 (1979).PubMedGoogle Scholar
  25. 25.
    Ohlsson, K. and Delshammar, M: Interaction between granulocyte elastase and the plasma proteinase inhibitors in vitro and in vivo, in: Dynamics of connective tissue macromolecules (Eds. PM Burleigh and A. R. Poole: North-Holland Pub!. Co., Amsterdam, 1975), pp. 259–275.Google Scholar
  26. 26.
    Sternberger, L.A., Hardy, P.H., Cuculis, I.J. and Meyer, H. G.: The unlabeled antibody enzyme method of immunochemistry: Preparation and properties of soluble antigen-antibody complex (Horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes. J. Histochem. Cytochem. 18,315 (1970).PubMedCrossRefGoogle Scholar
  27. 27.
    Cooke, T.D., Hurd,E.R., Jasin, H.E., Bienenstock, M and Ziff, M.: Identification of immunoglobulins and complement in rheumatoid articular collagenous tissues. Arthritis Rheum. 18,541 (1975).Google Scholar
  28. 28.
    Ishikawa, H., Smiley, J.D. and Ziff, M.: Electomicroscopic demonstration of immunoglobulin deposition in rheumatoid cartilage. Arthritis Rheum. 18,563 (1975).PubMedCrossRefGoogle Scholar
  29. 29.
    Jasin, H.E.: Deposition of immune complexes in collagenous tissues. In: Immunopathogenesis of Rheumatoid Arthritis, edited by G. S. Panayi and P.M. Johnson, 1979 Reedbooks Ltd., p. 89.Google Scholar
  30. 30.
    Oronsky, A., Ignarro, L. andPerper, R.: Release of cartilage mucopolysaccaride-degrading neutral protease from human leucocytes. J. Exp. Med. 138, 461 (1973).PubMedCrossRefGoogle Scholar
  31. 31.
    Henson, P.M.: The immunologic release of constituents from neutrophilleucocytes. II. Mechanisms of release during phagocytosis and adherence to nonphagocytosable surfaces. J. Immunol. 107, 1557 (1971).Google Scholar
  32. 32.
    Mohr, W. and Wessinghage, D.: The relationship between polymorphonuclear granulocytes and carilage destruction in rheumatoid arthritis. Z. Rheumatol. 37, 81 (1978).PubMedGoogle Scholar
  33. 33.
    Moh, w., Menninger, H., P rutzier, R.: Morphologische Hinweise fUr die Beteiligung neutrophiler Granulozyten an der rheumatischen Knorpeldestruktion. Bull. Schweiz. Akad. Med. Wiss. 35,443 1979).Google Scholar
  34. 34.
    Menninger, H., Putzier, R., Mohr, W., Wessinghage, D., Tillmann, K.: Granulocyte elastase at the site of cartilage erosion by rheumatoid synovial tissue. Z. Rheumatol. 39, 145 (1980).PubMedGoogle Scholar
  35. 35.
    Veivart, M. et al.: Detection of lysosomal elastase in joint cartilage of patients with rheumatoid arthritis: Manuskript in preparation.Google Scholar

Copyright information

© Dr. Dietrich Steinkopff Verlag GmbH & Co. KG, Darmstadt 1981

Authors and Affiliations

  • K. Fehr
    • 1
  • M. Velvart
    • 1
  • A. Baici
    • 1
  • M. Knöpfel
    • 1
  • G. Sommermeyer
    • 1
  • P. Salgam
    • 1
  • G. Cohen
    • 1
  • A. Böni
    • 1
  1. 1.RheumaklinikUniversitätsspital, ZürichSwitzerland

Personalised recommendations