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The Hypertrophied Heart pp 194–200Cite as

Transmural distribution of myocardial blood flow and of coronary reserve in canine left ventricular hypertrophy

Transmurale Verteilung der Myokarddurchblutung und der Koronarreserve in Hunden mit Hypertrophie des linken Ventrikels

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Summary

Left ventricular hypertrophy was induced by banding of the ascending aorta in puppies at the age of 6 weeks. At the age of one year left ventricular weight per body weight was increased by 87% compared to control litter mates. While myocardial perfusion and myocardial oxygen consumption per 100 g were identical in the hypertrophy and control group, there was a significantly diminished ratio of subendocardial/subepicardial flow in the hypertrophy group during moderate exercise. With maximal coronary dilation subendocardial diastolic resistance (mm Hg/ml · min-1 per 100 g) was 0.16 ± 0.03 in the control group and 0.26 ± 0.03 in the hypertrophy group. This diminished coronary reserve indicates an insufficient growth of the vascular bed in these hypertrophied hearts.

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References

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Author information

Authors and Affiliations

  1. Institute of Physiology, University of Munich, Pettenkoferstraße 12, D-8000, München 2, Germany

    J. Holtz, W. v. Restorff, P. Bard & E. Bassenge

Authors
  1. J. Holtz
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  2. W. v. Restorff
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  3. P. Bard
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  4. E. Bassenge
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Editor information

Editors and Affiliations

  1. Tübingen, Deutschland

    Ruthard Jacob

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© 1977 Dr. Dietrich Steinkopff Verlag, Darmstadt

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Holtz, J., v. Restorff, W., Bard, P., Bassenge, E. (1977). Transmural distribution of myocardial blood flow and of coronary reserve in canine left ventricular hypertrophy. In: Jacob, R. (eds) The Hypertrophied Heart. Steinkopff. https://doi.org/10.1007/978-3-642-85299-2_31

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  • DOI: https://doi.org/10.1007/978-3-642-85299-2_31

  • Publisher Name: Steinkopff

  • Print ISBN: 978-3-7985-0482-0

  • Online ISBN: 978-3-642-85299-2

  • eBook Packages: Springer Book Archive

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