Summary
Several proteins of the sarcomere differ from one muscle to the other, but it is also becoming evident that cardiac myosin, tropomyosin and troponin are species specific. Moreover, several properties of cardiac myosin could be modified under the influence of thyroxine, exercise, or overloading. These changes are closely related to the speed of shortening of the muscle and to the degree of stimulation of protein synthesis, but nobody is presently able to say if, in heart overloading, the modifications of myosin are a primary defect which is the origin of the failure or if they are only expressing a better adaptation of myocardial efficiency to the decrease of work.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Berson, G., B. Swynghedauw: Myofibrillar ATPase in rat’s experimental heart failure produced by a two steps mechanical overloading. Cardiovasc. Res. 7, 464 (1973).
Bhan, A. K., J. Scheuer: Effects of physical training on cardiac myosin ATPase activity. Amer. J. Physiol. 228, 1178 (1977).
Clark, A. J.: Comparative physiology of the heart, p. 119 (New York 1927 ).
Delcayre, C., B. Swynghedauw: A comparative study of heart myosin ATPase and light subunits from different species. Pflügers Arch. 355, 39 (1975).
Etlinger, J. D., R. Zak, D. A. Fischman, M. Rabinowitz: Isolation of newly synthetized myosin filaments from skeletal muscle homogenates and myofibrils. Nature 255, 259 (1975).
Goldspink, G.: Biochemical energetics for fast and slow muscles. In Comparative Physiology — L. Bolis, H. P. Maddrell, and K. Schmidt-Nielsen, p. 173–185 (Amsterdam 1975 ).
Huszar, G., M. Elzinga: Homologous methylated and non-methylated histidine peptides in skeletal and cardiac myosins. J. Biol. Chem. 247, 745 (1972).
Leclercq, J. F., B. Swynghedauw: Myofibrillar ATPase, DNA and OH Pro content of human hypertrophied heart. Europ. J. Clin. Invest. 6, 27 (1976).
Leger, J. J., G. Berson, C. Delcayre, C. Klotz, K. Schwartz, Joc. Leger, M. Stephens, B. Swynghedauw: Heart contractile proteins. Biochemie 57, 1249 (1975).
Millward, D. J., P. J. Garlick, D. O. Nnanyelugo, J. C. Waterlow: The relative importance of muscle protein synthesis and break-down in the regulation of muscle mass. Biochem. J. 156, 135 (1976).
Morkin, E.: Activation of synthetic processes in cardiac hypertrophy. Circulat. Res. 34 and 35, suppl. II, 37 (1974).
Swynghedauw, B., C. Klotz, J. J. Leger, P. Preteseille: Heart myosin ATPase and light subunits in experimental rabbit’s chronic aortic insufficiency. J. Mol. Cell. Cardiology 5, 501 (1973).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1977 Dr. Dietrich Steinkopff Verlag, Darmstadt
About this paper
Cite this paper
Swynghedauw, B., Schwartz, K., Léger, J.J. (1977). Cardiac myosin Phylogenic and pathological changes. In: Jacob, R. (eds) The Hypertrophied Heart. Steinkopff. https://doi.org/10.1007/978-3-642-85299-2_26
Download citation
DOI: https://doi.org/10.1007/978-3-642-85299-2_26
Publisher Name: Steinkopff
Print ISBN: 978-3-7985-0482-0
Online ISBN: 978-3-642-85299-2
eBook Packages: Springer Book Archive