Advertisement

Dynamics of the hypertrophied left ventricle in the rat. Effects of physical training and chronic pressure load

  • G. Kissling
  • M. F. Wendt-Gallitelli
Conference paper

Summary

Left ventricular hypertrophy of about 40 % was produced in rats by narrowing one renal artery (Goldblatt II) and of about 6 % by swimming-training for 2 hours a day for 14 weeks. The dynamics of the hypertrophied ventricles were investigated by means of the isovolumic systolic and diastolic pressure-volume relations, the stress development during afterloaded and isovolumic contractions, and the force-velocity relation. The following results were obtained: The performance of the whole hypertrophied ventricle is increased. The developed stress and the maximum rate of stress development are enhanced, probably as a consequence of the increased density of the contractile proteins. The maximum shortening velocity can be reduced at the same time.

Die Dynamik des hypertrophierten linken Ventrikels der Ratte. Einfluß von körperlichem Training und chronischer Druckbelastung

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Frank, O.: Zur Dynamik des Herzmuskels. Z. Biol. 32, 371 (1895).Google Scholar
  2. 2.
    Gotzen, R., G. Schultze: Das Blutvolumen in den verschiedenen Stadien der tierexperimentellen renovasculären Hypertonie. Verh. Dtsch. Ges. Inn. Med. 75, 194 (1969).PubMedGoogle Scholar
  3. 3.
    Heimchen, U.: Der relative Reninismus als ein pathogenetisches Prinzip der renalen Hypertonie. Habilitationsschrift (Tübingen 1973 ).Google Scholar
  4. 4.
    Hepp, A., M. Hansis, R. Gulch, R. Jacob: Left ventricular isovolumetric pressure-volume relations, “diastolic tone”, and contractility in the rat heart after physical training. Basic Res. Cardiol. 69, 516 (1974).Google Scholar
  5. 5.
    Jacob, R., A. Kämmereit, I. Medugorac, M. F. Wendt-Gallitelli: Myokardiale Leistungsfähigkeit, Maximalgeschwindigkeit der lastfreien Verkürzung (Vmax) und „Kontraktilitätsindices“ beim hypertrophierten Herzen. Z. Kardiol. 65, 392 (1976).PubMedGoogle Scholar
  6. 6.
    Kämmereit, A., I. Medugorac, R. Jacob: Dissociation of maximum shortening velocity (Vmax) and maximum instantaneous power of the hypertrophied ventricular myocardium of rats. Pflügers Arch. Suppl. 355, R 14 (1975).Google Scholar
  7. 7.
    Medugorac, I., A. Kämmereit, R. Jacob: Einfluß eines chronischen Schwimmtrainings auf Struktur und Enzymaktivität von Myosin beim Rattenmyokard. Hoppe-Seyler’s Z. Physiol. Chem. 356, 1161 (1975).CrossRefGoogle Scholar
  8. 8.
    Medugorac, I., R. Jacob: Concentration and adenosin-phosphatase activity of left ventricular actomyosin in Goldblatt rats during the compensatory stage of hypertrophy. Hoppe-Seyler’s Z. Physiol. Chem. 357, 1495 (1976).CrossRefGoogle Scholar
  9. 9.
    Mirsky, I., W. W. Parmley: Assessment of passive elastic stiffness for isolated heart muscle and the intact heart. Circulat. Res. 33, 233 (1973).PubMedGoogle Scholar
  10. 10.
    Sandler, H., H. T. Dodge: Left ventricular tension and stress in man. Circulat. Res. 13, 91 (1963).PubMedGoogle Scholar

Copyright information

© Dr. Dietrich Steinkopff Verlag, Darmstadt 1977

Authors and Affiliations

  • G. Kissling
    • 1
  • M. F. Wendt-Gallitelli
    • 1
  1. 1.Physiologisches Institut, Lehrstuhl IIUniversität TübingenTübingenDeutschland

Personalised recommendations