Abstract
In the intact circulation in man and dog dobutamine ( (±)-4-[2-[[3-(p-hydroxyphenyl)-1 -methylpropyl] amino]ethyl] pyrocatechol hydrochloride), a new synthetic catecholamine (Eli Lilly and Co., Indianapolis, Ind.) exerted marked positive inotropic effects (1–4). Since these effects were obtained with little change in heart rate and mean arterial pressure it has been suggested that dobutamine is potentially of clinical value in the enhancement of myocardial contractility and may have advantages over other frequently used catecholamines such as noradrenaline and isoproterenol (1–4). In view of the potential clinical value of dobutamine, and to exclude effects on the vascular system, this study was undertaken of characterize the direct effects of dobutamine on myocardial mechanics of the isolated cat papillary muscle.
Suppoted in part by USPHS HL 11306
Dr. Bodem is a research fellow of the Deutsche Forschungsgemeinschaft
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© 1974 Dr. Dietrich Steinkopff Verlag, Darmstadt
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Bodem, R., Skelton, C.L., Sonnenblick, E.H. (1974). Effects of dobutamine on myocardial mechanics. In: Thauer, R., Pleschka, K. (eds) Das Arterielle System. Verhandlungen Der Deutschen Gesellschaft für Kreislaufforschung, vol 40. Steinkopff. https://doi.org/10.1007/978-3-642-85290-9_41
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DOI: https://doi.org/10.1007/978-3-642-85290-9_41
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