EJB Reviews pp 27-41 | Cite as

T-cell antigen receptor-induced signal-transduction pathways Activation and function of protein kinases C in T lymphocytes

  • Marta Szamel
  • Klaus Resch
Part of the European Journal of Biochemistry book series (EJB REVIEWS, volume 1995)


The specificity of the immune response is determined by the interaction between T-cell antigen receptor and its cognate antigen. The T-cell antigen receptor and several coreceptors initiate parallel and interdependent signal transduction pathways. Protein-tyrosine phosphorylation is important in the initiation of cellular responses by the T-cell antigen receptor. As the T-cell receptor has no intrinsic protein-tyrosine kinase activity, activation of cytoplasmic non-receptor tyrosine-protein kinases is critical to the activation of lymphocytes. Both the src family of tyrosine kinases and the sck family of tyrosine-protein kinases play a role in T lymphocyte activation. The T-cell antigen receptor is coupled to this cluster of kinases by the cytoplasmic tails of the CD3 subunits. The distinct protein-tyrosine kinases interact with the T-cell receptor as well as with each other. At least one phosphoprotein phosphatase, CD45, can positively or negatively influence the T-cell receptor-induced signaling by dephosphorylating either src-related protein kinases or the receptor components.


T-lymphocyte T-cell activation signal transduction protein kinase C 





mitogen-activated protein


major histocompatibility complex


epidermal growth factor


platelet-derived growth factor


src homology




GTPaseactivating protein


phosphatidylinositol 4,5-bisphosphate


inositol 1,4,5-trisphosphate


phosphatidylinositol 3,4-bisphosphate


inositol 3,4,5-trisphosphate


nuclear factor of activated T-cells


protein kinase C


phospholipase A2


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Copyright information

© FEBS 1995

Authors and Affiliations

  • Marta Szamel
    • 1
  • Klaus Resch
    • 1
  1. 1.Institute of Molecular PharmacologyMedical School HannoverHannoverGermany

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