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Multimodale Therapieansätze bei der chirurgischen Therapie des Bronchialkarzinoms im Stadium III

  • P. Drings
  • A. Fritzsche
  • R. Loddenkemper
  • D. Kaiser
  • M. Wolf
  • K. Havemann
  • J. Schirren
  • W. Richter
  • C. Trainer
  • S. Trainer
  • P. Schneider
  • H. Bülzebruck
  • I. Vogt-Moykopf
  • G. Friedel
  • A. Linder
  • S. Weigang
  • P. Froeschle
  • H. Toomes
  • B. Kardjiev
  • W. Eberhardt
  • M. Stuschke
  • D. Greschuchna
Conference paper
Part of the Langenbecks Archiv für Chirurgie book series (DTGESCHIR, volume 1995)

Zusammenfassung

Im Stadium limited disease werden bei nicht-vorbehandelten Patienten durch die Kombination von Chemotherapie und Radiotherapie objektiv meßbare Remissionen in einer Häufigkeit von 70-95% erzielt. Die medianen Überlebensdauern der Patienten betragen 12 Monate, bei kompletten Remissionen 15-20 Monate. Nach 2 Jahren leben jedoch nur noch 5-10% der Patienten rezidivfrei. Bei den nicht-kleinz. Bronchialkarzinomen hat die Chemotherapie im Stadium IV mit Remissionsraten zwischen 25-45% ausschließlich palliativen Charakter. Neue Ergebnisse im Stadium III mit Remissionsraten zwischen 50-70% ergeben Ansätze für eine präoperative Induktionschemoth. bzw. einen erneuten Versuch der adjuvanten Chemotherapie.

Schlüsselwörter

Bronchialkarzinom kleinzellig Bronchialkarzinom nicht-kleinzellig Chemotherapie multimodale Therapie 

Summary

In nonpretreated patients with tumor stage ‘limited disease,’ a combination of chemotherapy and radiotherapy leads to remission rates of 70%–95%. The mean survival time of patients is 12 months, in complete remissions 15–20 months. However, after 2 years, only 5%–10% of patients are free of relapse. In stage IV (metastatic disease) of non-small-cell lung cancer (NSCLC), chemotherapy is only palliative, with remission rates between 25%–45%. In stage III,new results with remission rates between 50%–70% suggest treatment with preoperative induction chemotherapy or new attempts with adjuvant chemotherapy, respectively.

Key words

Small cell lung cancer (SCLC) Non-small-cell lung cancer (NSCLC) Chemotherapy Multimodal treatment Small cell lung cancer Operation Five-year survival Neoadjuvant chemotherapy Bronchial carcinoma Lymphadenectomy Prognostic factors Stage IIIA Non-small-cell lung cancer Surgery N 2 disease Stage III Non-small-cell cancer Neoadjuvant chemo-radiotherapy Restaging Remediastinoscopy 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • P. Drings
    • 1
  • A. Fritzsche
    • 2
  • R. Loddenkemper
    • 2
  • D. Kaiser
    • 2
  • M. Wolf
    • 3
    • 7
  • K. Havemann
    • 3
    • 7
  • J. Schirren
    • 4
  • W. Richter
    • 4
  • C. Trainer
    • 4
  • S. Trainer
    • 4
  • P. Schneider
    • 4
  • H. Bülzebruck
    • 4
  • I. Vogt-Moykopf
    • 4
  • G. Friedel
    • 5
  • A. Linder
    • 5
  • S. Weigang
    • 5
  • P. Froeschle
    • 5
  • H. Toomes
    • 5
  • B. Kardjiev
    • 6
  • W. Eberhardt
    • 6
  • M. Stuschke
    • 6
  • D. Greschuchna
    • 6
  1. 1.Abteilung Innere Medizin-OnkologieThoraxklinikHeidelbergDeutschland
  2. 2.Lungenklinik HeckeshornBerlinDeutschland
  3. 3.MarburgDeutschland
  4. 4.Thoraxchirurgische AbteilungThoraxklinikHeidelbergDeutschland
  5. 5.Thoraxchirurgische AbteilungKlinik SchillerhöheGerlingenDeutschland
  6. 6.RuhrlandklinikEssenDeutschland
  7. 7.MarburgDeutschland

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