Structure and Function of the Proteins Encoded by the myb Gene Family

  • C. Kanei-Ishii
  • T. Nomura
  • K. Ogata
  • A. Sarai
  • T. Yasukawa
  • S. Tashiro
  • T. Takahashi
  • Y. Tanaka
  • S. Ishii
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 211)


The nuclear proto-oncogene c-myb is the cellular homologue of the v-myb gene carried by the chicken leukemia viruses avian myelobastosis virus (AMV) and E26, which transform avian myeloid cells in vitro and in vivo (for review, see ref. 1). c-myb expression is linked to the differentiation state of the cell, since expression is down-regulated during terminal differentiation of hemopoietic cells (2) and constitutive expression of introduced c-myb blocks the induced differentiation of erythroleukemia (3). In addition, antisense oligonucleotides to c-myb appear to impede in vitro hematopoiesis (4) and homozygous c-myb mutant mice displayed a specific failure of fetal hepatic hematopoiesis (5). These results all indicate a role for c-myb in maintaining the proliferative state of hematopoietic progenitor cells. Both c-Myb and v-Myb are transcriptional activators (6–9). The v-myb proteins (v-Myb) encoded by AMV and E26 are amino (N)- and carboxyl (C)-terminally truncated versions of c-Myb. In this report, we shall address the structure and function of each functional domain in c-Myb, and also the relationship between the retroviral-transforming v-myb genes and its cellular homologue, the c-myb gene, to ask whether changes in the control of transcription may account for the generation of the transformation phenotype.


Leucine Zipper Oncogenic Activation Heat Shock Element Transcriptional Activation Domain Cellular Homologue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • C. Kanei-Ishii
    • 1
  • T. Nomura
    • 1
  • K. Ogata
    • 1
  • A. Sarai
    • 1
  • T. Yasukawa
    • 1
  • S. Tashiro
    • 1
  • T. Takahashi
    • 1
  • Y. Tanaka
    • 1
  • S. Ishii
    • 1
  1. 1.Tsukuba Life Science CenterThe Institute of Physical & Chemical Research (RIKEN)Tsukuba, IbarakiJapan

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