Structure and Function of the Proteins Encoded by the myb Gene Family

  • C. Kanei-Ishii
  • T. Nomura
  • K. Ogata
  • A. Sarai
  • T. Yasukawa
  • S. Tashiro
  • T. Takahashi
  • Y. Tanaka
  • S. Ishii
Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 211)

Abstract

The nuclear proto-oncogene c-myb is the cellular homologue of the v-myb gene carried by the chicken leukemia viruses avian myelobastosis virus (AMV) and E26, which transform avian myeloid cells in vitro and in vivo (for review, see ref. 1). c-myb expression is linked to the differentiation state of the cell, since expression is down-regulated during terminal differentiation of hemopoietic cells (2) and constitutive expression of introduced c-myb blocks the induced differentiation of erythroleukemia (3). In addition, antisense oligonucleotides to c-myb appear to impede in vitro hematopoiesis (4) and homozygous c-myb mutant mice displayed a specific failure of fetal hepatic hematopoiesis (5). These results all indicate a role for c-myb in maintaining the proliferative state of hematopoietic progenitor cells. Both c-Myb and v-Myb are transcriptional activators (6–9). The v-myb proteins (v-Myb) encoded by AMV and E26 are amino (N)- and carboxyl (C)-terminally truncated versions of c-Myb. In this report, we shall address the structure and function of each functional domain in c-Myb, and also the relationship between the retroviral-transforming v-myb genes and its cellular homologue, the c-myb gene, to ask whether changes in the control of transcription may account for the generation of the transformation phenotype.

Keywords

Leukemia Carboxyl Serine Alanine Tryptophan 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • C. Kanei-Ishii
    • 1
  • T. Nomura
    • 1
  • K. Ogata
    • 1
  • A. Sarai
    • 1
  • T. Yasukawa
    • 1
  • S. Tashiro
    • 1
  • T. Takahashi
    • 1
  • Y. Tanaka
    • 1
  • S. Ishii
    • 1
  1. 1.Tsukuba Life Science CenterThe Institute of Physical & Chemical Research (RIKEN)Tsukuba, IbarakiJapan

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