Abstract
A characteristic pericentric inversion of chromosome 16 [inv(l6)(p13q22)] is consistently associated with acute myelomonocytic leukemia with eosinophilia (AML M4Eo). This type of leukemia comprises 8% of AML cases and affects approximately 2,000 people each year in the United States. In addition to inv(l6), a number of other unique features are associated with AML M4Eo, including the presence of morphologically and histochemically abnormal eosinophils, a relatively good prognosis, and possibly frequent involvement of the central nervous system (for review see Liu etal. 1995)
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© 1996 Springer-Verlag Berlin Heidelberg
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Hajra, A., Liu, P.P., Collins, F.S. (1996). Transforming Properties of the Leukemic Inv(16) Fusion Gene CBFB-MYH11 . In: Wolff, L., Perkins, A.S. (eds) Molecular Aspects of Myeloid Stem Cell Development. Current Topics in Microbiology and Immunology, vol 211. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85232-9_29
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DOI: https://doi.org/10.1007/978-3-642-85232-9_29
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