Involvement of the TEL Gene in Hematologic Malignancy by Diverse Molecular Genetic Mechanisms

  • T. R. Golub
  • G. F. Barker
  • K. Stegmaier
  • D. G. Gilliland
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 211)


Cloning of chromosome translocation breakpoints have identified abnormal gene products which contribute to the pathogenesis of hematologic malignancy. Examples include the PML-RARα fusion associated with t(15; 17) acute promyelocytic leukemia (APML)(1’3), the AMLl-ETO fusion associated with t(8;21) acute myeloid leukemia (4), the CBFβ-MYHII fusion associated with inv(16) acute myelomonocytic leukemia and eosinophilia (5), and MLL fusions at 11q23 breakpoints with various fusion proteins associated with acute myeloid leukemias (6).


Acute Myeloid Leukemia Acute Lymphoblastic Leukemia Fusion Partner Tyrosine Kinase Domain Translocation Breakpoint 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • T. R. Golub
    • 1
  • G. F. Barker
    • 1
  • K. Stegmaier
    • 1
  • D. G. Gilliland
    • 1
  1. 1.Division of Hematology/Oncology, Department of MedicineBrigham and Women’s Hospital and Children’s Hospital. Harvard Medical SchoolBostonUSA

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