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Pathogenetic Role of the PML/RARα Fusion Protein in Acute Promyelocytic Leukemia

  • Conference paper
Molecular Aspects of Myeloid Stem Cell Development

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 211))

Abstract

Acute promyelocytic leukemia (APL) is characterized by a differentiation block at the promyelocytic stage of myeloid differentiation [1]. The differentiation block is the most distinctive biological feature of this leukemia since APL blasts have a modest proliferative rate [2] and the release of the block and terminal differentiation obtained with retinoic acid (RA) correlates in vivo with complete hematological remission in the great majority of APL patients [3–5].

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Authors and Affiliations

  1. Istituto di Medicina Interna e Scienze Oncologiche, Perugia University, Policlinico Monteluce, 06100, Perugia, Italy

    F. Grignani & P. G. Pelicci

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  1. F. Grignani
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  2. P. G. Pelicci
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Editors and Affiliations

  1. Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bldg. 37, Rm. 1 B16, 37 Convent Drive MSC 4255, Bethesda, MD, 20892-4255, USA

    Linda Wolff Ph.D. (Senior Investigator) (Senior Investigator)

  2. Department of Pathology, Yale University School of Medicine, P.O. Box 208023, New Haven, CT, 06520-8023, USA

    Archibald S. Perkins M.D., Ph.D. (Assistant Professor) (Assistant Professor)

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© 1996 Springer-Verlag Berlin Heidelberg

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Grignani, F., Pelicci, P.G. (1996). Pathogenetic Role of the PML/RARα Fusion Protein in Acute Promyelocytic Leukemia. In: Wolff, L., Perkins, A.S. (eds) Molecular Aspects of Myeloid Stem Cell Development. Current Topics in Microbiology and Immunology, vol 211. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85232-9_27

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  • DOI: https://doi.org/10.1007/978-3-642-85232-9_27

  • Publisher Name: Springer, Berlin, Heidelberg

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