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The Neurofibromatosis Type 1 (NF1) Tumor Suppressor Gene and Myeloid Leukemia

  • Conference paper
Book cover Molecular Aspects of Myeloid Stem Cell Development

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 211))

Abstract

Activating mutations of RAS genes are a common event in the genesis of a wide variety of human tumor types (for review see Barbacid 1990). It has also become increasingly clear that many tumors without RAS gene mutations have acquired genetic lesions that contribute to tumorigenesis by causing increased or prolonged activation of Ras. In this paper we review and describe studies using human and mouse cells on the association between NF1 gene loss and the development of myeloid leukemia. The NF1 gene product, neurofibromin, has GTPase activating protein (GAP) activity for Ras and thus, could negatively regulate Ras. Therefore, NF1 gene loss in myeloid cells may contribute to leukemogenesis by activating Ras.

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Author information

Authors and Affiliations

  1. Mammalian Genetics Laboratory, ABL-Basic Research Program, NCI-Frederick Cancer Research and Development Center, Frederick, MD, 21702, USA

    D. A. Largaespada, J. D. Shaughnessy, N. A. Jenkins & N. G. Copeland

  2. Department of Molecular Genetics and Microbiology and Center for Mammalian Genetics, University of Florida, Gainesville, FL, 32610, USA

    C. I. Brannan

Authors
  1. D. A. Largaespada
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  2. C. I. Brannan
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  3. J. D. Shaughnessy
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  4. N. A. Jenkins
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  5. N. G. Copeland
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Editor information

Editors and Affiliations

  1. Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bldg. 37, Rm. 1 B16, 37 Convent Drive MSC 4255, Bethesda, MD, 20892-4255, USA

    Linda Wolff Ph.D. (Senior Investigator) (Senior Investigator)

  2. Department of Pathology, Yale University School of Medicine, P.O. Box 208023, New Haven, CT, 06520-8023, USA

    Archibald S. Perkins M.D., Ph.D. (Assistant Professor) (Assistant Professor)

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© 1996 Springer-Verlag Berlin Heidelberg

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Largaespada, D.A., Brannan, C.I., Shaughnessy, J.D., Jenkins, N.A., Copeland, N.G. (1996). The Neurofibromatosis Type 1 (NF1) Tumor Suppressor Gene and Myeloid Leukemia. In: Wolff, L., Perkins, A.S. (eds) Molecular Aspects of Myeloid Stem Cell Development. Current Topics in Microbiology and Immunology, vol 211. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85232-9_23

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  • DOI: https://doi.org/10.1007/978-3-642-85232-9_23

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-85234-3

  • Online ISBN: 978-3-642-85232-9

  • eBook Packages: Springer Book Archive

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