Molecular Analysis and Characterization of Two Myeloid Leukemia Inducing Murine Retroviruses

  • E. Rassart
  • J. Houde
  • C. Denicourt
  • M. Ru
  • C. Barat
  • E. Edouard
  • L. Poliquin
  • D. Bergeron
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 211)

Abstract

Murine retroviruses (MuLVs) induce a large variety of hematopoietic tumors through complex mechanisms involving insertional activation of cellular proto-oncogenes in the tumor cell (for review see [1,2]). The type of tumor induced generally depends on sequences located in the viral enhancer [3–5] but also on coding sequences from other regions of the viral genome [6–8]. The Cas-Br-E MuLV is an ecotropic retrovirus that induces hindlimb paralysis in susceptible strains of mice [9]. It also induces mainly non-T, non-B-cell leukemia in infected NIH/Swiss mice [10–12]. The tumor cells show a very undifferentiated blast cell morphology which suggest that they are immature precursors.

Keywords

Zinc Lymphoma Codon Leukemia Anemia 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • E. Rassart
    • 1
  • J. Houde
    • 1
  • C. Denicourt
    • 1
  • M. Ru
    • 1
  • C. Barat
    • 1
  • E. Edouard
    • 1
  • L. Poliquin
    • 1
  • D. Bergeron
    • 1
  1. 1.Laboratoire de biologie moléculaire, Département des sciences biologiquesUniversité du Québec à MontréalMontréalCanada

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