Molecular Analysis and Characterization of Two Myeloid Leukemia Inducing Murine Retroviruses

  • E. Rassart
  • J. Houde
  • C. Denicourt
  • M. Ru
  • C. Barat
  • E. Edouard
  • L. Poliquin
  • D. Bergeron
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 211)


Murine retroviruses (MuLVs) induce a large variety of hematopoietic tumors through complex mechanisms involving insertional activation of cellular proto-oncogenes in the tumor cell (for review see [1,2]). The type of tumor induced generally depends on sequences located in the viral enhancer [3–5] but also on coding sequences from other regions of the viral genome [6–8]. The Cas-Br-E MuLV is an ecotropic retrovirus that induces hindlimb paralysis in susceptible strains of mice [9]. It also induces mainly non-T, non-B-cell leukemia in infected NIH/Swiss mice [10–12]. The tumor cells show a very undifferentiated blast cell morphology which suggest that they are immature precursors.


Chronic Myeloid Leukemia Murine Leukemia Virus Viral Integration Insertional Activation Thymic Enlargement 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • E. Rassart
    • 1
  • J. Houde
    • 1
  • C. Denicourt
    • 1
  • M. Ru
    • 1
  • C. Barat
    • 1
  • E. Edouard
    • 1
  • L. Poliquin
    • 1
  • D. Bergeron
    • 1
  1. 1.Laboratoire de biologie moléculaire, Département des sciences biologiquesUniversité du Québec à MontréalMontréalCanada

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