Coordinate Regulation of Neutrophil Secondary Granule Protein Gene Expression

  • A. Khanna-Gupta
  • T. Zibello
  • N. Berliner
Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 211)

Abstract

Evidence from study of both normal and leukemic cells suggests that a crucial step in neutrophil maturation occurs in the transition from the promyelocyte to the myelocyte stage. The transition from the promyelocyte to the myelocyte in normal marrow cells is accompanied both by the loss of proliferative capacity associated with terminal maturation [1], and by the loss of the capacity for alternative maturation [2]. Normal promyelocytes respond to stimuli of both granulocyte and monocyte differentiation, but myelocytes are restricted to terminal granulocyte maturation [2]. In this regard, it is striking that acute myeloid leukemias invariably involve proliferation of cells arrested in development at or before the promyelocyte stage. Consequently, an understanding of the transition from the promyelocyte to the myelocyte stage should provide crucial insights into both the control mechanisms governing normal hematopoietic cell differentiation and the ways in which disruption of the control mechanisms can contribute to leukemic transformation.

Keywords

Carbohydrate DMSO Leukemia Dimethyl Sorting 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Janoshowitz H, Moore MAS, Metcalf D (1971) Density gradient segregation of bone marrow cells with the capacity to form granulocytic and macrophage colonies in vitro Exp Cell Res 68: 220–224CrossRefGoogle Scholar
  2. 2.
    Warner HR, Athens JW (1964) Analysis of granulocyte kinetics in blood and bone marrow. Ann NY Acad Sci 113: 523–535PubMedCrossRefGoogle Scholar
  3. 3.
    Bainton DF (1975) Neutrophil granules Br J Hematol 29: 17–22CrossRefGoogle Scholar
  4. 4.
    Bainton DF, Ullyot JL, Farquhar MG (1971) The development of the neutrophilic polymorphonuclear leukocytes in human bone marrow. J Exp Med 134: 907–34PubMedCrossRefGoogle Scholar
  5. 5.
    Lomax KJ, Gallin JI, Benz EJ, Rado TA, Boxer LA, Malech HL (1989) Selective defect in myeloid cell lactoferrin gene expression in neutrophil specific granule deficiency J Clin Invest 83: 514–519PubMedCrossRefGoogle Scholar
  6. 6.
    Carmel R (1983) R-Binder deficiency: A clinically benign cause of cobalamin pseudodefi-ciency. J Amer Med Assoc 250: 1886–1890CrossRefGoogle Scholar
  7. 7.
    Parmley RT, Tzeng DY, Baehner RL, Boxer LA (1983) Abnormal distribution of complex carbohydrates in neutrophils of a patient with lactoferrin deficiency. Blood 62: 538–548PubMedGoogle Scholar
  8. 8.
    Johnston J, Bollekens J, Allen RH, Berliner N (1989) Structure of the cDNA encoding transcobalamin I, a neutrophil granule protein J Biol Chem 264:15754–15757PubMedGoogle Scholar
  9. 9.
    Devarajan P, Mookhtiar K, Van Wart H, Berliner N (1991) Structure and expression of the cDNA encoding human neutrophil collagenase Blood 77:2731–2738PubMedGoogle Scholar
  10. 10.
    Johnston J, Yang-Feng T, Berliner N (1991) Structure and mapping of the chromosomal gene encoding human transcobalamin I: Comparison to human intrinsic factor Genomics 12: 459–464Google Scholar
  11. 11.
    Johnston J, Rintels P, Chung J, Sather J, Benz EJ, Berliner N (1992) The lactoferrin gene promoter: Structural integrity and non-expression in HL60 cells Blood 79: 2998–3006PubMedGoogle Scholar
  12. 12.
    Devarajan P, Johnston J, Ginsberg S, Van Wart H, Berliner N (1992) Structure and expression of neutrophil gelatinase cDNA: Identity with Type IV collagenase from HT1080 cells J Biol Chem. 267: 25228–25232PubMedGoogle Scholar
  13. 13.
    Graubert T, Johnston J, Berliner N (1993) Cloning and expression of the cDNA encoding mouse neutrophil gelatinase: Demonstration of coordinate secondary granule protein gene expression during terminal neutrophil maturation. Blood 82: 3192–3197PubMedGoogle Scholar
  14. 14.
    Berliner N, Hsing A, Sigurdsson F, Zain M, Graubert T, Bruno E, Hoffman R (1995) G-CSF induction of normal human marrow progenitors results in neutrophil-specific gene expression. Blood 85:799–803PubMedGoogle Scholar
  15. 15.
    Collins SJ, Ruscett FW, Gallagher RE (1977) Normal functional characteristics of cultured human promyelocytic leukemia cells (HL-60) after induction of differentiation by dimethylsulfoxide. Nature 270:347–349PubMedCrossRefGoogle Scholar
  16. 16.
    Fibach E, Peled T, Treves A, Koraberg A, Rachmilewitz E (1982) Modulation of the maturation of human leukemic promyelocytes (HL-60) to granulocytes or macrophages Leukemia Res 6: 781–790CrossRefGoogle Scholar
  17. 17.
    Miyauchi J, Watanabe Y, Enomoto Y, Takeuchi K (1983) Lactoferrin deficient polymorphonuclear leucocytes in leukemias: A semiquantitative and ultrastructural eytochemical study J Clin Pathol 36:1397–1405PubMedCrossRefGoogle Scholar
  18. 18.
    Fearon ER, Burke PJ, Schiffer CA, Zehnbauer BA, Vogelstein B (1986) Differentiation of leukemia cells to polymorphonuclear leukocytes in patients with acute nonlymphocytic leukemia. N Engl J Med 315: 15–24PubMedCrossRefGoogle Scholar
  19. 19.
    Khanna-Gupta A, Kolibaba K, Berliner N (1994) NB4 cells exhibit bilineage potential and an aberrant pattern of neutrophil secondary granule protein gene expression Blood 84: 294–302PubMedGoogle Scholar
  20. 20.
    Johnston J, Boxer LA, Berliner N (1992) Correlation of RNA levels with protein deficiencies in specific granule deficiency. Blood 80: 2088–2091PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • A. Khanna-Gupta
    • 1
  • T. Zibello
    • 1
  • N. Berliner
    • 1
  1. 1.Yale University School of MedicineUSA

Personalised recommendations