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A Role for STAT Family Transcription Factors in Myeloid Differentiation

  • Conference paper
Molecular Aspects of Myeloid Stem Cell Development

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 211))

Abstract

STAT family transcription factors regulate gene expression in response to a wide variety of cytokines. A transcription factor designated differentiation-induced factor (DIF), activated by treatment of myeloid cells with the differentiating agents interferon-gamma (IFN-γ), granulocyte-macrophage colony-stimulating factor (GM-CSF), colony-stimulating factor-1 (CSF-1) or during phorbol ester-induced differentiation, was characterized as a 112kDa protein related to, but not identical with known isoforms of STAT 5. Taken together with previously published results, our data suggest an important function for members of the STAT 5 subfamily in regulating gene expression during the process of myeloid differentiation.

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Authors and Affiliations

  1. Vienna Biocenter, Institute of Microbiology and Genetics, Dr. Bohr-Gasse 9, A-1030, Vienna, Austria

    F. Barahmand-pour, A. Meinke, Matthias Kieslinger, A. Eilers & T. Decker

Authors
  1. F. Barahmand-pour
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  2. A. Meinke
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  3. Matthias Kieslinger
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  4. A. Eilers
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  5. T. Decker
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Editors and Affiliations

  1. Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bldg. 37, Rm. 1 B16, 37 Convent Drive MSC 4255, Bethesda, MD, 20892-4255, USA

    Linda Wolff Ph.D. (Senior Investigator) (Senior Investigator)

  2. Department of Pathology, Yale University School of Medicine, P.O. Box 208023, New Haven, CT, 06520-8023, USA

    Archibald S. Perkins M.D., Ph.D. (Assistant Professor) (Assistant Professor)

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© 1996 Springer-Verlag Berlin Heidelberg

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Barahmand-pour, F., Meinke, A., Kieslinger, M., Eilers, A., Decker, T. (1996). A Role for STAT Family Transcription Factors in Myeloid Differentiation. In: Wolff, L., Perkins, A.S. (eds) Molecular Aspects of Myeloid Stem Cell Development. Current Topics in Microbiology and Immunology, vol 211. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85232-9_12

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  • DOI: https://doi.org/10.1007/978-3-642-85232-9_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-85234-3

  • Online ISBN: 978-3-642-85232-9

  • eBook Packages: Springer Book Archive

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