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Molecular Control of Development in Normal and Leukemic Myeloid Cells by Cytokines, Tumor Suppressor and Oncogenes

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Book cover Molecular Aspects of Myeloid Stem Cell Development

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 211))

Abstract

The establishment of a cell culture system for the clonal development of hematopoietic cells made it possible to discover the proteins that regulate cell viability, multiplication and differentiation of different hematopoietic cell lineages and the molecular basis of normal and abnormal development in blood-forming tissues (reviewed in [1–5]). These regulators include cytokines now called colony stimulating factors (CSFs) and interleukins (ILs) and hematopoiesis is controlled by a network of cytokine interactions [1–7]. This multigene network includes positive regulators such as CSFs and ILs and negative regulators such as transforming growth factor β and tumor necrosis factor. The cytokine network which has arisen during evolution allows considerable flexibility depending on which part of the network is activated and the ready amplification of response to a particular stimulus. Hematopoietic cytokines can induce the expression of transcription factors [8]. Cytokine signalling through transcription factors can thus ensure the autoregulation and transregulation of cytokine genes that occur in the network.

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References

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Authors and Affiliations

  1. Department of Molecular Genetics and Virology, Weizmann Institute of Science, Rehovot, 76100, Israel

    L. Sachs

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  1. L. Sachs
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Editors and Affiliations

  1. Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bldg. 37, Rm. 1 B16, 37 Convent Drive MSC 4255, Bethesda, MD, 20892-4255, USA

    Linda Wolff Ph.D. (Senior Investigator) (Senior Investigator)

  2. Department of Pathology, Yale University School of Medicine, P.O. Box 208023, New Haven, CT, 06520-8023, USA

    Archibald S. Perkins M.D., Ph.D. (Assistant Professor) (Assistant Professor)

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© 1996 Springer-Verlag Berlin Heidelberg

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Sachs, L. (1996). Molecular Control of Development in Normal and Leukemic Myeloid Cells by Cytokines, Tumor Suppressor and Oncogenes. In: Wolff, L., Perkins, A.S. (eds) Molecular Aspects of Myeloid Stem Cell Development. Current Topics in Microbiology and Immunology, vol 211. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85232-9_1

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  • DOI: https://doi.org/10.1007/978-3-642-85232-9_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-85234-3

  • Online ISBN: 978-3-642-85232-9

  • eBook Packages: Springer Book Archive

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