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The National Cancer Institute Silicone Implant/Multiple Myeloma Registry

  • Conference paper
Immunology of Silicones

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 210))

Abstract

Following the initial report that the intraperitoneal injection of silicone gels leads to plasmacytoma formation in genetically susceptible strains of mice [1], clinical case-reports have appeared of multiple myeloma and monoclonal gammopathy of 0undetermined significance (MGUS) in people with silicone-implants. To characterize the cases identified to date, the National Cancer Institute has established a Silicone Implant/Multiple Myeloma Registry. The Registry also includes patients with MGUS and is not restricted to females, but only female patients with multiple myeloma are included in this report. Several individual series of cases have been reported earlier [2] (and see also other chapters in this volume), and some of these cases are also included herein.

Dr. Rabkin attests that he has no financial related to silence implants nor any participation in silicone-related litigation.

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References

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Author information

Authors and Affiliations

  1. Viral Epidemiology Branch, National Cancer Institute, Bethesda, MD, 20892, USA

    C. S. Rabkin

  2. Department of Medicine, University of California, Los Angeles, CA, 90211, USA

    S. Silverman

  3. Developmental Therapeutics, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA

    G. Tricot

  4. H. Lee Moffitt Cancer Center, University of South Florida College of Medicine, Tampa, FL, 33612, USA

    L. L. Garland & O. Ballester

  5. Laboratory of Genetics, National Cancer Institute, Bethesda, MD, 20892, USA

    M. Potter

Authors
  1. C. S. Rabkin
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  2. S. Silverman
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  3. G. Tricot
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  4. L. L. Garland
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  5. O. Ballester
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  6. M. Potter
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Editor information

Editors and Affiliations

  1. Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bldg. 37, Rm. 2B04, 37 Convent Drive MSC 4255, Bethesda, MD, 20892-4255, USA

    Michael Potter M.D. (Chief) (Chief)

  2. Departments of Pathology and of Molecular Microbiology and Immunology, John Hopkins University, 615 N. Wolfe Street, Rm. 4027, Baltimore, MD, 21205, USA

    Noel R. Rose M.D. Ph.D. (Professor of Pathology and Molecular Microbiology and Immunology) (Professor of Pathology and Molecular Microbiology and Immunology)

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© 1996 Springer-Verlag Berlin Heidelberg

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Rabkin, C.S., Silverman, S., Tricot, G., Garland, L.L., Ballester, O., Potter, M. (1996). The National Cancer Institute Silicone Implant/Multiple Myeloma Registry. In: Potter, M., Rose, N.R. (eds) Immunology of Silicones. Current Topics in Microbiology and Immunology, vol 210. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85226-8_41

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  • DOI: https://doi.org/10.1007/978-3-642-85226-8_41

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-85228-2

  • Online ISBN: 978-3-642-85226-8

  • eBook Packages: Springer Book Archive

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