Abstract
Monoclonal gammopathy of undetermined significance (MGUS) is characterized by the presence of a serum monoclonal protein (M-protein) less than 3 g/dL; fewer than 10 percent plasma cells in the bone marrow; no or only small amounts of M-protein (Bence Jones protein) in the urine; absence of lytic lesions, anemia, hypercalcemia, and renal insufficiency; and most importantly, stability of the M-protein and failure of development of other abnormalities. Detection of an M-protein is accomplished by electrophoresis on agarose or cellulose acetate followed by immunoelectrophoresis or immunofixation. The latter is more sensitive and is particularly useful when one is searching for a small M-protein (Kyle, 1994).
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© 1996 Springer-Verlag Berlin Heidelberg
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Kyle, R.A. (1996). Monoclonal Gammopathy of Undetermined Significance. In: Potter, M., Rose, N.R. (eds) Immunology of Silicones. Current Topics in Microbiology and Immunology, vol 210. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85226-8_40
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DOI: https://doi.org/10.1007/978-3-642-85226-8_40
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