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Monoclonal Gammopathy of Undetermined Significance

  • Conference paper
Immunology of Silicones

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 210))

Abstract

Monoclonal gammopathy of undetermined significance (MGUS) is characterized by the presence of a serum monoclonal protein (M-protein) less than 3 g/dL; fewer than 10 percent plasma cells in the bone marrow; no or only small amounts of M-protein (Bence Jones protein) in the urine; absence of lytic lesions, anemia, hypercalcemia, and renal insufficiency; and most importantly, stability of the M-protein and failure of development of other abnormalities. Detection of an M-protein is accomplished by electrophoresis on agarose or cellulose acetate followed by immunoelectrophoresis or immunofixation. The latter is more sensitive and is particularly useful when one is searching for a small M-protein (Kyle, 1994).

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References

  • Axelsson U (1986) A 20-year follow up study of 64 subjects with M-components. Acta Med 219:519–522

    Article  CAS  Google Scholar 

  • Axelsson U, Bachman R, Hällén J (1966) Frequency of pathological proteins (M-components) in 6,995 sera from an adult population. Acta Med Scand 179:235–247

    Article  PubMed  CAS  Google Scholar 

  • Belisle LM, Case DC Jr & Neveux L (1990) Quantitation of risk of malignant transformation in patients with “benign” monoclonal gammopathy (BMG) (Abstract). Blood 76(Suppl l):342a

    Google Scholar 

  • Bladé J, Lopez-Guillermo A, Rozman C et al (1992) Malignant transformation and life expectancy in monoclonal gammopathy of undetermined significance. Br J Haematol 81:391–394

    Article  PubMed  Google Scholar 

  • Gabriel SE, O’Fallon WM, Kurland LT, Beard CM, Woods JE, Melton III LJ (1994) Risk of connective-tissue diseases and other disorders after breast implantation. N Engl J Med 330:1697–1702

    Article  PubMed  CAS  Google Scholar 

  • Giraldo MP, Rubio-Félix D, Perella M et al (1991) Aspectos clinicos, biológicos y evolutivos de 397 casos. Sangre 36:377–382

    PubMed  CAS  Google Scholar 

  • Kyle RA (1993) “Benign” monoclonal gammopathy—after 20 to 35 years of follow up. Mayo Clin Proc 68:26–36

    PubMed  CAS  Google Scholar 

  • Kyle RA (1994) The monoclonal gammopathies. Clin Chem 40:2154–2161

    PubMed  CAS  Google Scholar 

  • Kyle RA, Finkelstein S, Elveback LR, Kurland LT (1972) Incidence of monoclonal proteins in a Minnesota community with a cluster of multiple myeloma. Blood 40:719–724

    PubMed  CAS  Google Scholar 

  • Kyle RA, Beard CM, O’Fallon WM, Kurland LT (1994) Incidence of multiple myeloma in Olmsted County, Minnesota: 1978 through 1990, with a review of the trend since 1945. J Clin Oncol 12:1577–1583

    PubMed  CAS  Google Scholar 

  • Kyle RA, Greipp PR (1980) Series on clinical testing. 3. The laboratory investigation of monoclonal gammopathies. Mayo Clin Proc 53:719–739

    Google Scholar 

  • Miller BA, Ries LA, Hankey BF, et al (1993) SEER Cancer Statistics Review 1973-1990. NIH Publ No. 93-2789, Bethesda, Maryland: NCI

    Google Scholar 

  • Paladini G, Fogher M, Mazzanti G et al (1989) Idiopathic monoclonal gammopathy: long-term study of 313 cases. Recent Prog 80:123–132

    CAS  Google Scholar 

  • Potter M, Morrison S, Wiener F, Zhang XK, Miller FW (1994) Induction of plasmacytomas with silicone gel in genetically susceptible strains of mice. J Natl Cancer Inst 86:1058–1065

    Article  PubMed  CAS  Google Scholar 

  • Saleun JP, Vicariot M, Deroff P (1982) Monoclonal gammopathies in the adult population of Finistère, France. J Clin Pathol 35:63–68

    Article  PubMed  CAS  Google Scholar 

  • Salmon SE, Kyle RA (1994) Silicone gels, induction of plasma cell tumors, and genetic susceptibility in mice: a call for epidemiologic investigation of women with silicone breast implants. J Natl Cancer Inst 86:1042–1041

    Google Scholar 

  • Witzig TE, Kyle RA & Greipp PR (1992) Circulating peripheral blood plasma cells in multiple myeloma. Curr Topics Microbiol Immunol 182:195–199

    Article  CAS  Google Scholar 

  • Witzig TE, Kyle RA, O’Fallon WM & Greipp PR (1994) Detection of peripheral blood plasma cells as a predictor of disease course in patients with smouldering multiple myeloma. Br J Haematol 87:266–272

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Division of Hematology and Internal Medicine, Mayo Clinic and Mayo Foundation, USA

    R. A. Kyle Consultant, Professor of Medicine and Laboratory Medicine

  2. Mayo Medical School, Rochester, Minnesota, USA

    R. A. Kyle Consultant, Professor of Medicine and Laboratory Medicine

Authors
  1. R. A. Kyle Consultant, Professor of Medicine and Laboratory Medicine
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Editor information

Editors and Affiliations

  1. Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bldg. 37, Rm. 2B04, 37 Convent Drive MSC 4255, Bethesda, MD, 20892-4255, USA

    Michael Potter M.D. (Chief) (Chief)

  2. Departments of Pathology and of Molecular Microbiology and Immunology, John Hopkins University, 615 N. Wolfe Street, Rm. 4027, Baltimore, MD, 21205, USA

    Noel R. Rose M.D. Ph.D. (Professor of Pathology and Molecular Microbiology and Immunology) (Professor of Pathology and Molecular Microbiology and Immunology)

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© 1996 Springer-Verlag Berlin Heidelberg

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Kyle, R.A. (1996). Monoclonal Gammopathy of Undetermined Significance. In: Potter, M., Rose, N.R. (eds) Immunology of Silicones. Current Topics in Microbiology and Immunology, vol 210. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85226-8_40

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  • DOI: https://doi.org/10.1007/978-3-642-85226-8_40

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-85228-2

  • Online ISBN: 978-3-642-85226-8

  • eBook Packages: Springer Book Archive

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