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Is the Risk of Multiple Myeloma Increased in Patients with Silicone Implants?

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Immunology of Silicones

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 210))

Abstract

Clonal expansion and selection mediated by antigen stimulation has been hypothesized to contribute to the development of multiple myeloma (MM). Numerous case reports and epidemiologic surveys have linked chronic infections and inflammatory disorders to an increased incidence of MM 1,2 . Silicone implants have been associated with an increased incidence of auto-immune disorders. Much of the available information on the pathogenesis of plasma cell tumors comes from induction of peritoneal plasmacytomas by plastics and paraffin oils, such as pristane. This model does not appear to require carcinogens, transforming retroviruses or radiation. It relies upon genetic predisposition and natural mutations for the generation of the genetic changes in B cells leading to autonomous growth3. It is therefore conceivable that chronic antigen stimulation with silicone could lead to multiple myeloma in genetically predisposed individuals.

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References

  1. Isobe T and Osserman EF. Pathologic conditions associated with plasma cell dyscrasias: a study of 806 cases. Ann. N. Y. Acad. Sci. 90:507–518, 1971.

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  2. Schafer AL and Miller JB. Association of IgA multiple myeloma with preexisting disease. Br. J. Haematol. 41:19–24, 1979.

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  3. Potter M. Perspectives on the origins of multiple myeloma and plasmacytomas in mice. Hematology/Oncology Clinics of North America 6:211–223, 1992.

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Author information

Authors and Affiliations

  1. Arkansas Cancer Research Center, University of Arkansas for Medical Sciences, 4301 West Markham, Slot 508, Little Rock, AR, 72205, USA

    G. J. K. Tricot M.D., Ph.D., S. Naucke R.N., L. Vaught B.A., D. Vesole M.D., Ph.D., S. Jagannath M.D. & B. Barlogie M.D., Ph.D.

Authors
  1. G. J. K. Tricot M.D., Ph.D.
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  2. S. Naucke R.N.
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  3. L. Vaught B.A.
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  4. D. Vesole M.D., Ph.D.
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  5. S. Jagannath M.D.
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  6. B. Barlogie M.D., Ph.D.
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Editor information

Editors and Affiliations

  1. Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bldg. 37, Rm. 2B04, 37 Convent Drive MSC 4255, Bethesda, MD, 20892-4255, USA

    Michael Potter M.D. (Chief) (Chief)

  2. Departments of Pathology and of Molecular Microbiology and Immunology, John Hopkins University, 615 N. Wolfe Street, Rm. 4027, Baltimore, MD, 21205, USA

    Noel R. Rose M.D. Ph.D. (Professor of Pathology and Molecular Microbiology and Immunology) (Professor of Pathology and Molecular Microbiology and Immunology)

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© 1996 Springer-Verlag Berlin Heidelberg

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Tricot, G.J.K., Naucke, S., Vaught, L., Vesole, D., Jagannath, S., Barlogie, B. (1996). Is the Risk of Multiple Myeloma Increased in Patients with Silicone Implants?. In: Potter, M., Rose, N.R. (eds) Immunology of Silicones. Current Topics in Microbiology and Immunology, vol 210. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85226-8_37

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  • DOI: https://doi.org/10.1007/978-3-642-85226-8_37

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-85228-2

  • Online ISBN: 978-3-642-85226-8

  • eBook Packages: Springer Book Archive

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