Novel Anti-Silicone Surface-Associated Antigen Antibodies (Anti-SSAA(x)) May Help Differentiate Symptomatic Patients with Silicone Breast Implants from Patients with Classical Rheumatological Disease

  • N. Kossovsky
  • D. Conway
  • R. Kossowsky
  • D. Petrovich
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 210)

Abstract

The frequency of novel autoreactive antibodies to silicone surface associated antigens (anti-SSAA(x)) was measured in healthy control patients, symptomatic patients with breast implants, asymptomatic patients with breast implants, and control patients with classical rheumatological diseases. The frequencies of elevated anti-SSAA(x) antibodies in 310 symptomatic breast implant patients were 17.4% anti-SSAA(fn), 12.9% anti-SSAA(coll), and 7.4% anti-SSAA(col3) and 7.1% anti-SSAA(fbgn) [Normal (n=173) = 0.6% for all four tests] (p>.005). In 11 asymptomatic breast implant patients, the frequencies of elevated values for the same anti-SSAA’s were 0%, 9%, 0%, and 0% respectively, while in 50 patients with rheumatoid arthritis, the frequencies were 4%, 0%, 6% and 2% respectively. The anti-SSAA(x) profile for symptomatic patients with breast implants was different than the profile for control healthy patients (p>.005 on all eight tests) but differed significantly by two measures, anti-SSAA(fbgn) and anti-SSAA(col3), from the profile for the 19 patients with systemic lupus erythematosus. We conclude that anti-SSAA(x) antibodies levels in symptomatic patients with breast implants are elevated, that the antibodies are associated with symptoms, and that they differ both qualitatively and quantitatively from healthy controls, asymptomatic patients with breast implants, and symptomatic patients with classical rheumatological diseases.

Keywords

Arthritis Syringe Bicarbonate Polyacrylamide Polystyrene 

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References

  1. 1.
    Kossovsky N and Freiman CJ: Silicone breast implant pathology: Clinical data and immunologic consequences. Arch Path Lab Med 1994; 118:686–693.PubMedGoogle Scholar
  2. 2.
    Farber E.Textbook of Pathology, WB Saunders, New York, 1994.Google Scholar
  3. 3.
    Kossovsky N, Zeidler M, Chun G, Nugyen A, Rajguru S, Papasian N, Gelman A, Sponsler E: Surface dependent antigens identified by high binding avidity of serum antibodies in a subpopulation of patients with breast prostheses. J of Appl Biomat., 1993, 4::281–288.CrossRefGoogle Scholar
  4. 4.
    Kossovsky N, Gornbein JA, Zeidler M, Stassi J, Chun G, Papasian N, Nguyen A, Ly K, Rajguru S: Self reported signs and symptoms in breast implant patients with novel antibodies to silicone-surface-adsorbed antigens (anti-SSAA). J Appl Biomat 1995 IN PRESSGoogle Scholar
  5. 5.
    Kossovsky N, Heggers JP, Robson MC. The bioreactivity of silicone. In: Williams DF, Ed CRC Critical Reviews in Biocompatibility. Boca Raton: CRC Press; 1987: 3:53–85.Google Scholar
  6. 6.
    Council on Scientific Affairs, American Medical Association. Silicone gel breast implants. JAMA 1993; 270:2602–2606.CrossRefGoogle Scholar
  7. 7.
    Sergott TJ, Limoli JP, Baldwin CM, Laub DR: Human adjuvant disease, Possible autoimmune disease after silicone implantation. Plast. Reconstr. Surg. 1986; 78:104–114.PubMedCrossRefGoogle Scholar
  8. 8.
    Weiner SR and Paulus HE. Chronic arthropathy occuring after augmentation mammaplasty. Plast Reconstr Surg 1986; 77:185–192.PubMedCrossRefGoogle Scholar
  9. 9.
    Grisolia JS, Herndon R, Ostermeyer-Shoaib B, Lezak M, Prange R, and Boksenbaum S. spectrum of atypical neurology disease and cognitive disorders panels. Presented at the Silicone Related Disorders Study Group Workshop, New Orleans, 21-22 April 1995.Google Scholar
  10. 10.
    Silverman S, Berenson J, Silver D, Vescio R and Persselin J. Multiple myeloma. Two case histories and the incidence of increased immunoglobulin and monoclonal gammopathy in women with silicone breast implants. Presented at the NCI/NIH Workshop on the Immunology of Silicones, Bethesda, 13-14 March 1995.Google Scholar
  11. 11.
    Bernstein, RA: Humoral autoimmunity in systemic rheumatic disease. A review. J Roy Coll Phys (London) 1990; 24:18–25.Google Scholar
  12. 12.
    Gabriel SE, O’Fallon WM, Kuland LT, Beard CM, Woods JE, Melton LJ: Risk of connective tissue diseases and other disorders after breast implantation. N Engl J Med 1994; 330:1697–1702.PubMedCrossRefGoogle Scholar
  13. 13.
    Teuber SS, Rowley MJ, Yoshida SH, Ansari AA, Gershwin ME: Anti-collagen antibodies are found in women with silicone breast implants. Autoimmunity 1993; 6:367–377.CrossRefGoogle Scholar
  14. 14.
    Tennenbaum SA, Cuellar ML, Citera G, Silveira LH, Garry RF and Espinoza LR. Presented at the annual meeting of American College of Rheumatology, San Antonio, TX, November, 1993. Abstract published in Arthritis & Rheumatism 1993;36:S118,A123.Google Scholar
  15. 15.
    Wolf, LE, Lappe, M, Peterson, RD, Ezrailson, EG: Human immune response to polydimethylsiloxane (silicone). Screening studies in a breast implant population. FASEB J, 1993; 7:1265–1268PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • N. Kossovsky
    • 1
  • D. Conway
    • 2
  • R. Kossowsky
    • 3
  • D. Petrovich
    • 3
  1. 1.Department of PathologyUCLA School of MedicineLos AngelesUSA
  2. 2.Information and Operations Management Department, School of Business AdministrationUniversity of Southern CaliforniaLos AngelesUSA
  3. 3.SBI Laboratories, Forbes Med-Tech CenterPittsburghUSA

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