Abstract
We assessed the prevalence of autoantibodies in women with silicone implants and controls. Five hundred consecutive patients with silicone implants, 25 age-matched normal women, 25 women with silicone implants and no rheumatic symptoms, and 100 women with fibromyalgia were tested. Immunofluorescence antinuclear antibodies (ANA) were performed using HEp-2 cells. Subtype autoantibodies were performed by enzyme-linked immunoassay and Western blot. ANA tests were positive in 30% of patients with silicone implants and rheumatic symptoms, 8% of age-matched normal women, 28% of women with silicone implants without clinical symptoms, and 25% of women with fibromyalgia and no silicone implants. The predominant ANA pattern was speckled (55%). ANA subtype testing was positive in 4.8% of patients and none of the controls. We conclude that a larger proportion of women with silicone implants have autoantibodies compared to age-matched asymptomatic women suggesting immune activation in women with silicone implants.
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References
Bridges A (1993) Fibromyalgia antinuclear antibodies and clinical features of connective tissue disease. Clin Exp Rheumatol 11:696–697.
Bridges A, Anderson J, Wang G, Johnson J, Sharp G (1995) Comparison of hemagglutination, immunodiffusion and immunoblotting methods for detecting autoantibodies to small nuclear ribonucleoproteins (Sm and RNP). Lab Med 26:150–156.
Bridges AJ, Conley C Wang G, Burns D, Vasey F (1993) A clinical and immunologic evaluation of women with silicone breast implants and symptoms of rheumatic disease. Ann Intern Med 118:929–936.
Claman HN, Robertson AD (1994) Antinuclear antibodies and breast implants. West J Med 160:225–228.
Dinerman H, Goldenberg DL, Felson DT (1986) A prospective evaluation of 118 patients with fibromyalgia syndrome: Prevalence of Raynaud’s phenomenon, sicca symptoms, ANA, Low complement, and Ig deposition at the dermal-epidermal junction. J Rheumatol 13:368–373.
Peters W, Keystone E, Snow K, Rubin L, Smith D (1994) Is there a relationship between autoantibodies and silicone-gel implants? Ann Plast Surg 32:1–7.
Press RI, Peebles CL, Kumagai Y, Ochs RL, Tan EM (1992) Antinuclear autoantibodies in women with silicone breast implants. Lancet 340:1304–1307.
Tan EM. (1989) Antinuclear antibodies: diagnostic markers for autoimmune diseases and probes for cell biology. Adv Immunol 44:93–151.
Sternberg EM (1993) Hypoimmune fatigue syndrome response? J Rheumatol 20:418–421.
Wolfe F, Smythe HA, Yunus MB, et al (1990) The American College Of Rheumatology 1990 criteria for the classification of fibromyalgia. Arthritis Rheum 33:160–172.
Yunus MB, Hussey FX, Aldag JC (1993) Antinuclear antibodies and connective tissue disease features in fibromyalgia syndrome: a controlled study. J Rheumatol 20:1557–1560.
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© 1996 Springer-Verlag Berlin Heidelberg
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Bridges, A.J., Anderson, J.D., Burns, D.E., Kemple, K., Kaplan, J.D., Lorden, T. (1996). Autoantibodies in Patients with Silicone Implants. In: Potter, M., Rose, N.R. (eds) Immunology of Silicones. Current Topics in Microbiology and Immunology, vol 210. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85226-8_28
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DOI: https://doi.org/10.1007/978-3-642-85226-8_28
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