Silicone Binding Immunoglobulins in Human Sera

Rose, N. R.; Landavere, M.; Kuppers, R. C.

doi:10.1007/978-3-642-85226-8_27

N. R. Rose^12,13,
M. Landavere^12,13 &
R. C. Kuppers¹³^nAff14

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 210))

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Abstract

We have evaluated two recently published test procedures for demonstrating antibodies to silicone. Positive control serum samples provided to us by the original authors were positive in our hands, using the methods described. However, serum samples from patients with certain connective tissue diseases but no history of silicone implants were also positive. The question of silicone-specific antibodies remains unresolved.

Dr. Rose has served as an expert witness for defendants in several legal proceedings involving silicone breast implants.

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References

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Author information

R. C. Kuppers
Present address: SAIC - Life Sciences Operation, 5340 Spectrum Drive, Suite N, Frederick, MD, 21701, USA

Authors and Affiliations

Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, 21205, USA
N. R. Rose & M. Landavere
Department of Molecular Microbiology and Immunology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, 21205, USA
N. R. Rose, M. Landavere & R. C. Kuppers

Authors

N. R. Rose
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M. Landavere
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R. C. Kuppers
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Editors and Affiliations

Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bldg. 37, Rm. 2B04, 37 Convent Drive MSC 4255, Bethesda, MD, 20892-4255, USA
Michael Potter M.D. (Chief) (Chief)
Departments of Pathology and of Molecular Microbiology and Immunology, John Hopkins University, 615 N. Wolfe Street, Rm. 4027, Baltimore, MD, 21205, USA
Noel R. Rose M.D. Ph.D. (Professor of Pathology and Molecular Microbiology and Immunology) (Professor of Pathology and Molecular Microbiology and Immunology)

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Rose, N.R., Landavere, M., Kuppers, R.C. (1996). Silicone Binding Immunoglobulins in Human Sera. In: Potter, M., Rose, N.R. (eds) Immunology of Silicones. Current Topics in Microbiology and Immunology, vol 210. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85226-8_27

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DOI: https://doi.org/10.1007/978-3-642-85226-8_27
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-85228-2
Online ISBN: 978-3-642-85226-8
eBook Packages: Springer Book Archive

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