Abstract
There has been much controversy about whether women with breast implants are at increased risk for autoimmune disease, particularly scleroderma [1–7]. Associations between breast implants and autoimmunity have been asserted [8–10] nd denied [11–14]. We performed a cross-sectional analysis of two cohorts of women with breast implants who considered themselves healthy together with suitable controls. A serum test for antinuclear antibodies (ANA) was the laboratory marker studied.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Baldwin CM, Kaplan EN (1983) Silicone-induced human adjuvant disease? Ann Plast Surg 10:270–273
Sergott TJ, Limoli JP, Baldwin Jr. CM, et al (1986) Human adjuvant disease, possible autoimmune disease after silicone implantation: A review of the literature, case studies, and speculation for the future. Plast Reconstr Surg 78:104–114
Endo LP, Edwards NL, Longley S, Corman LC, Panush RS (1987) Silicone and rheumatic diseases. Arthritis Rheum 17:112–118
Fock K, Feng P, Tey B (1984) Autoimmune disease developing after augmentation mammoplasty: Report of three cases. J Rheumatol 11:98–100
Varga J, Heiman-Patterson TD, Emery DL, Griffin R, Lally EV, Uitto JJ, Jimenez SA (1990) Clinical spectrum of the systemic manifestations of the eosinophilia-myalgia syndrome. Semin Arthritis Rheum 19:313–328
Press RI, Peebles CL, Kumagai Y, Ochs RL, Tan EM (1992) Antinuclear autoantibodies in women with silicone breast implants. Lancet 340:1304–1307
Bridges AJ, Conley C, Wang G, Burnes DE, Vasey FB (1993) A clinical and immunologie evaluation of women with silicone breast implants and symptoms of rheumatic disease. Ann Int Med 118:929–936
Brozena SJ, Fenske NA, Cruse CW, et al (1988) Human adjuvant disease following augmentation mammoplasty. Arch Dermatol 124:1383–1386
Gutierrez F, Espinoza LR (1990) Progressive systemic sclerosis complicated by severe hypertension: Reversal after silicone implant removal. Am J Med 89:390–392
Kumagai Y, Shiokawa Y, Medsger Jr. TA, Rodnan GP (1984) Clinical spectrum of connective tissue disease after cosmetic surgery: Observation on 18 patients and a review of the Japanese literature. Arthritis Rheum 27:1–12
Shons AR, Schubert W (1992) Silicone breast implants and immune disease. Ann Plast Surg 28:491–501
Peters W, Keystone E, Snow K, Rubin L, Smith D (1994) Is there a relationship between autoantibodies and silicone-gel implants? Ann Plast Surg 32:1–7
Gabriel SE, O’Fallon WM, Kurland LT, Beard CM, Woods JE, Melton III LJ (1994) Risk of connective-tissue diseases and other disorders after breast implantation. N Engl J Med 330:1697–1702
Sanchez-Guerrero J, Schur PH, Sergent JS, Liang MH (1994) Silicone breast implants and rheumatic disease: clinical, immunologic, and epidemiologic studies. Arthritis Rheum 37:158–168
Claman HN, Robertson AD (1994) Antinuclear antibodies and breast implants. West J Med 160:225–228
Nairn JO, Lanzafame RJ, van Oss CJ (1993) The adjuvant effect of silicone-gel on antibody formation in rats. Immunological Investigations 22:151–161
Potter M, Morrison S, Wiener F, Zhang XK, Miller FW (1994) Induction of plasmacytomas with silicone gel in genetically susceptible strains of mice. J Natl Cancer Inst 86:1058–1065
Yadin O, Sarov B, Naggan L, Slor H, Schoenfeld Y (1989) Natural autoantibodies in the serum of healthy women-a five-year follow-up. Clin Exp Immunol 75:402–406
Moore JE, Lutz WO (1955) Natural history of systemic lupus erythematosus: an approach to its study through chronic biologic false-positive reactors. J Chron Dis 1:297
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1996 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Claman, H.N., Robertson, A.D. (1996). Antinuclear Antibodies in Apparently Healthy Women with Breast Implants. In: Potter, M., Rose, N.R. (eds) Immunology of Silicones. Current Topics in Microbiology and Immunology, vol 210. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85226-8_26
Download citation
DOI: https://doi.org/10.1007/978-3-642-85226-8_26
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-85228-2
Online ISBN: 978-3-642-85226-8
eBook Packages: Springer Book Archive