Microscopic Techniques and Histologic Findings in Silicone Mammary Implant Capsules and Regional Paranodal Tissues

  • D. R. Shanklin
  • D. L Smalley
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 210)


The best known silicone medical devices are mammary implant prostheses. Capsular fibrosis is a common result after use of these devices. An acute inflammatory reaction occurs adjacent to silicone mammary implants shortly after insertion in experimental animals [1-3]. This is expected on the basis of surgical creation of an artificial tissue plane for the prosthesis independent of reaction to silicone by adjacent connective tissues. Vistnes et al. did not quantify the acute reaction after ten days, noting rather that it became minimal by 42 days [3]. The singular difference from a simple surgical plane without foreign material lies in the early formation of a planar capsule, which thickened only slightly with time in the absence of silicone spillage [3]. Vistnes et al. reported thicker capsules both early and late following prosthetic rupture [3]. We have seen few comparable early human tissues but clinical assessments [4-6] have been reported since 1965 [5], shortly after the introduction of silicone devices for human use. Moreover, cAMP as a chemical marker for acute inflammatory reaction has been found in both human and animal material [7]; experimental work has shown comparable cellular responses to intraperitoneal injection of silicones [8].


Breast Implant Capsular Contracture Dark Field Microscopy Acute Inflammatory Reaction Capsular Fibrosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • D. R. Shanklin
    • 1
    • 2
  • D. L Smalley
    • 1
  1. 1.Department of PathologyUniversity of TennesseeMemphisUSA
  2. 2.Department of Obstetrics and GynecologyUniversity of TennesseeMemphisUSA

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