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Structure and Function of Natural Antibodies

  • Conference paper
Immunology of Silicones

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 210))

Abstract

The presence of immunoglobulins (Ig) in the circulation of normal humans and animals that bind a variety of foreign antigens, such as bacterial components and products, viruses, protozoa, fungi, as well as self antigens, such as nucleic acids, phospholipids, erythrocytes, serum proteins, cellular components, insulin and thy-roglobulin, has been recognized since the beginning of this century [1–9]. Because their emergence is independent of known and/or intentional immunization, these antibodies have been termed “natural antibodies”. In contrast to antigen-induced antibodies, which are mainly IgG and monoreactive, a considerable proportion of natural antibodies are IgM and polyreactive, that is they bind several unrelated antigens with different affinities. Natural polyreactive and monoreactive IgG and IgA antibodies also exist [7]. The vast majority of natural antibodies, whether IgM, IgG or IgA, are produced by CD5+ B cells, the predominant lymphocytes in the neonatal cell repertoire [10,11]. Because of their broad reactivity with a variety of microbial components, diese antibodies may play a major role in the primary line of defense against infections. Owing to their ability to bind self antigens, they may serve as templates for some of the high-affinity autoantibodies that emerge in patients with autoimmune disease, particularly those associated with a significant expansion of CD5+ B cells [12–14].

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  1. The Division of Molecular Immunology, Department of Pathology, Cornell University Medical College, New York, New York, 10021-4896, USA

    P. Casali & E. W. Schettino

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  1. P. Casali
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  2. E. W. Schettino
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Editors and Affiliations

  1. Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bldg. 37, Rm. 2B04, 37 Convent Drive MSC 4255, Bethesda, MD, 20892-4255, USA

    Michael Potter M.D. (Chief) (Chief)

  2. Departments of Pathology and of Molecular Microbiology and Immunology, John Hopkins University, 615 N. Wolfe Street, Rm. 4027, Baltimore, MD, 21205, USA

    Noel R. Rose M.D. Ph.D. (Professor of Pathology and Molecular Microbiology and Immunology) (Professor of Pathology and Molecular Microbiology and Immunology)

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© 1996 Springer-Verlag Berlin Heidelberg

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Casali, P., Schettino, E.W. (1996). Structure and Function of Natural Antibodies. In: Potter, M., Rose, N.R. (eds) Immunology of Silicones. Current Topics in Microbiology and Immunology, vol 210. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85226-8_17

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  • DOI: https://doi.org/10.1007/978-3-642-85226-8_17

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