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Induction of Type II Collagen Arthritis in the DA Rat Using Silicone Gel as Adjuvant

  • Conference paper
Immunology of Silicones

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 210))

Abstract

The Dark Agouti (DA) rat has been shown recently to have a high susceptibility for developing arthritis when challenged with either heterologous or homologous collagen II mixed with mineral oil, or with mineral oil challenge alone. This study determined the arthritogenic potential of silicone gel by either mixing it with bovine collagen II (BE) or by injecting silicone gel alone in DA rats. The incidence of collagen induced arthritis was as follows: PBS group- 0/10, silicone gel group- 4/10, and IFA group- 8/9. Anti-BII antibodies were formed in most of the rats treated with either silicone gel or IFA and these groups of rats showed a positive DTH reaction. The PBS treated rats were negative for both anti-BII antibodies and DTH reaction. The incidence of arthritis formation in rats injected with silicone gel alone was 0/10, while the IFA injected rats showed an incidence of 8/10. Silicone gel taken from a commercial breast implant thus is capable of mediating collagen induced arthritis in the DA rat. However, silicone gel alone does not appear to be arthritogenic.

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Author information

Authors and Affiliations

  1. Department of Surgery, Rochester General Hospital, Rochester, NY, USA

    J. O. Naim, K. M. L. Ippolito & R. J. Lanzafame

  2. The University of Rochester, School of Medicine and Dentistry, Rochester, NY, USA

    J. O. Naim & R. J. Lanzafame

  3. Department of Microbiology, SUNY at Buffalo, Buffalo, NY, USA

    J. O. Naim & C. J. van Oss

Authors
  1. J. O. Naim
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  2. K. M. L. Ippolito
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  3. R. J. Lanzafame
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  4. C. J. van Oss
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Editor information

Editors and Affiliations

  1. Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bldg. 37, Rm. 2B04, 37 Convent Drive MSC 4255, Bethesda, MD, 20892-4255, USA

    Michael Potter M.D. (Chief) (Chief)

  2. Departments of Pathology and of Molecular Microbiology and Immunology, John Hopkins University, 615 N. Wolfe Street, Rm. 4027, Baltimore, MD, 21205, USA

    Noel R. Rose M.D. Ph.D. (Professor of Pathology and Molecular Microbiology and Immunology) (Professor of Pathology and Molecular Microbiology and Immunology)

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© 1996 Springer-Verlag Berlin Heidelberg

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Naim, J.O., Ippolito, K.M.L., Lanzafame, R.J., van Oss, C.J. (1996). Induction of Type II Collagen Arthritis in the DA Rat Using Silicone Gel as Adjuvant. In: Potter, M., Rose, N.R. (eds) Immunology of Silicones. Current Topics in Microbiology and Immunology, vol 210. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85226-8_11

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  • DOI: https://doi.org/10.1007/978-3-642-85226-8_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-85228-2

  • Online ISBN: 978-3-642-85226-8

  • eBook Packages: Springer Book Archive

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