Legionella pneumophila Invasion of Mononuclear Phagocytes

  • H. A. Shuman
  • M. A. Horwitz
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 209)

Abstract

Legionella pneumophila is a gram-negative bacterium that causes legionnaires’ disease. This organism is widespread in fresh water and is typically found growing in association with protozoans and blue-green algae. In human beings, L pneumophila infects alveolar macrophages, wherein the organism survives and replicates within a specialized phagosome or vacuole (the Legionella-specialized phagosome, LSP). The interaction between L. pneumophila and human mononuclear phagocytes has been studied in considerable detail, and it provides an interesting and informative example of how one organism successfully achieves intracellular parasitism.

Keywords

Tuberculosis Bacillus Interferon Charcoal Ferritin 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • H. A. Shuman
    • 1
  • M. A. Horwitz
    • 2
  1. 1.Department of Microbiology, College of Physicians and SurgeonsColumbia UniversityNew YorkUSA
  2. 2.Division of Infectious Diseases, Department of Medicine, School of MedicineUniversity of California, Los AngelesLos AngelesUSA

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