Legionella pneumophila Invasion of Mononuclear Phagocytes
Legionella pneumophila is a gram-negative bacterium that causes legionnaires’ disease. This organism is widespread in fresh water and is typically found growing in association with protozoans and blue-green algae. In human beings, L pneumophila infects alveolar macrophages, wherein the organism survives and replicates within a specialized phagosome or vacuole (the Legionella-specialized phagosome, LSP). The interaction between L. pneumophila and human mononuclear phagocytes has been studied in considerable detail, and it provides an interesting and informative example of how one organism successfully achieves intracellular parasitism.
KeywordsHuman Monocyte Mononuclear Phagocyte Complement Receptor Major Outer Membrane Protein Intracellular Multiplication
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