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Invasion and the Pathogenesis of Shigella Infections

  • Chapter
Bacterial Invasiveness

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 209))

Abstract

Bacillary dysentery, or shigellosis, is caused by penetration of Shigella spp into the intestinal mucosa of the colon, where degeneration of the epithelium and a strong inflammatory reaction indicate sites of infection (LABREC et al. 1964). Clinical signs of shigellosis range from mild diarrhea to severe dysentery with blood, mucus, and pus in the stool. Epidemiological studies indicate that SHIGELLA are transmitted by the fecal-oral route and sometimes by contaminated food (WHARTON et al. 1990). Shigella are highly infectious organisms for human beings, since only a few hundred bacteria administrated orally caused disease in 50% of volunteers (DUPONT et al. 1989).

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Authors and Affiliations

  1. Unité de Pathogénie Microbienne Moléculaire, Unité INSEM 389, Département de Bactériologie et de Mycologie, Institut Pasteur, 25 rue du Dr Roux, Paris Cedex 15, 75724, France

    C. Parsot & P. J. Sansonetti

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  1. C. Parsot
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  2. P. J. Sansonetti
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Editors and Affiliations

  1. Department of Microbiology and Molecular Genetics, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, CA, 90095, USA

    Virginia L. Miller Ph.D.

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© 1996 Springer-Verlag Berlin Heidelberg

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Parsot, C., Sansonetti, P.J. (1996). Invasion and the Pathogenesis of Shigella Infections. In: Miller, V.L. (eds) Bacterial Invasiveness. Current Topics in Microbiology and Immunology, vol 209. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85216-9_2

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  • DOI: https://doi.org/10.1007/978-3-642-85216-9_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-85218-3

  • Online ISBN: 978-3-642-85216-9

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