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Safety Requirements for Maintenance and Distribution of Transgenic Mice Susceptible to Human Viruses: The Example of Poliovirus-Susceptible Transgenic Mice

  • Y. Ghendon
  • P.-H. Lambert
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 206)

Abstract

During the last few years, considerable progress has been achieved in obtaining transgenic mice containing parts of the human genome and susceptible to human viruses. The establishment of such animal models has proven to be extremely useful. Research leading to the development of improved methods for the prevention and control of serious human viral diseases is often limited by the absence of readily available animal models capable of mimicking human interactions with the viral agent. Examples of viral diseases in which efforts have been restricted by the lack of such animal models include the acquired immunodeficiency syndrome and all forms of viral hepatitis and poliomyelitis. In each case, only certain nonhuman primate species have been shown to be susceptible to infection. The nonhuman primates which are required for such experimental work are expensive to acquire and maintain, often limited in availability, or even an endangered species.

Keywords

Transgenic Mouse Transgenic Animal Human Virus Olfactory Neuroblastoma Poliovirus Type 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Abramczuk JW, Penson DS, Leonard J, Monell-Torrens E, Belcher J, Martin M, Notkins AL (1992) Transgenic mice carrying intact HIV provirus: biological effects and organization of a transgene. J Acquir Innume Defic Syndr 5: 196–203Google Scholar
  2. Aguzzi A, Wagner EF, Williams R, Courtheidge SA (1990) Sympathetic hyperplasia and neuro-blastomas in transgenic mice expressing polyoma middle T antigen. New Biol 2: 533–543PubMedGoogle Scholar
  3. Aguzzi A, Bothe K, Anthauser I, Horak I, Rethwilm A, Wagner E (1992) Expression of human foamy virus is differentially regulated during development in transgenic mice. New Biol 4: 225–237PubMedGoogle Scholar
  4. Animals Scientific Procedures Act (UKJ); Animal Welfare Act (USA); Law Concerning the Protection and Control of Animals (Japan); Tier Schutzgestetz (Germany); The UFAW Handbook on the Care and Management of Laboratory Animals (YFAW, UK); Guide for the Care and Use of Laboratory Animals (UFAW, UK); Guide for the Care and Use of Laboratory Animals (ILAR, USA); Standards Relating to the Care and Management of Experimental Animals (Prime Minister’s Office, Japan); International Guiding Principles for Biomédical Research Involving Animals (CIOMS); Laws regulating Genetic Engineering Issues in the FRG; Society for Laboratory Animal Science: Zur Planung und Structur von Versuchstierbereichen tierexperimentell tätiger Institutionen 1988; WHO/ICLAS Guidelines for the Establishment of Animal Colonies and Use of Laboratory Animals (WHO, Geneva, in preparation)Google Scholar
  5. Araki K, Nishimura S, Ochiya T, Okybo K, Miyazaki J, Matsubara K, Yamamura K (1991) Production and effect of infectious Dane particles in transgenic mice Jpn J Cancer Res 82: 235–239Google Scholar
  6. Beggs AH, Miner JH, Scangos GA (1990) Cell type-specific expression of JC virus T antigen in primary and established cell lines from transgenic mice. J Gen Virol 71: 151–164PubMedCrossRefGoogle Scholar
  7. Bills ND, Hinrichs SH, Morgan R, Clifford AJ (1992) Delayed tumor onset in transgenic mice fed a low-folate diet. J Natl Cancer Inst 84: 332–337PubMedCrossRefGoogle Scholar
  8. Choo KB, Liew LN, Chong KY, Lu RH, Cheng WT (1991) Transgenome transcription and replication in the liver and extrahetatic tissues of a human hepatitis B virus transgenic mouse. Virology 182: 785–792PubMedCrossRefGoogle Scholar
  9. Choo KB, Chong KY, Liew LN, Hsu HC, Cheng WT (1992) Unregulated and basal transcriptional activities of the regulatory sequence of the type 18 human papillomavirus genome in transgenic mice. Virology 188: 378–383PubMedCrossRefGoogle Scholar
  10. Dunsford HA, Sell S, Chisari FV (1990) Hepatocarcinogenesis due to chronic liver cell injury in hepatitis B virus transgenic mice. Cancer Res 50: 3400–3407PubMedGoogle Scholar
  11. Genetic Manipulation Guidelines on Work with Transgenic Animals (Home Office, UK); Guidelines for Recombinant DNA Experiments (Ministry of Education, Science and Culture, Japan); Cornell directive on the contained use of genetically modified micro organisms (USA); Laws Regulating Genetic Engineering Issues in the FRGGoogle Scholar
  12. Gonzalez-Dunia D, Grimber G, Briard P, Brahic M, Ozden S (1992) Tissue expression pattern directed in transgenic mice by the LTR of an HTLV-1 provirus isolated from a case of tropical spastic paraparesis. Virology 187: 705–710PubMedCrossRefGoogle Scholar
  13. Live Animal Regulations (IATA): The UFAW Handbook on the Care and Management of Laboratory Animals (UFAW, UK): Guide for the Care and Use of Laboratory Animals (ILAR, USA); Standards Relation to the Care and Management of Experimental Animals (Prime Minister’s Office, Japan); International Guiding Principles for Biomédical Research Involving Animals (CIOMS); WHO/ICLAS Guidelines for the Establishment of Animal Colonies and Use of Laboratory Animals, Chapter 14 (WHO, Geneva, in preparation)Google Scholar
  14. Furth PA, Hennighausen L, Baker C, Beatty B, Woychick R (1991) The variability in activity of the universally expressed human cytomegalovirus immediate early gene I, enhancer/promoter in transgenic mice. Nucleic Acids Res 19: 6205–6208PubMedCrossRefGoogle Scholar
  15. International Guiding Principles for Biomédical Research Involving Animals, CIMS, Geneva 1985Google Scholar
  16. Iwakura Y, Tosu M, Yoshida E, Takiguchi M, Sato K, Kitajima I (1991) Induction of inflammatory arthrpathy resembling rheumatoid arthritis in mice transgenic for HTLV-1. Science 253: 1026–1028PubMedCrossRefGoogle Scholar
  17. Jolicoeur P, Laperriere A, Beaulieu N (1992) Efficient production of human immunodeficiency virus proteins in transgenic mice. J Virol 66: 3904–3908PubMedGoogle Scholar
  18. Koike K, Jay G, Hartley JW, Schrenzel MD, Higgins R, Hinrichs S (1990) Activiation of retrovirus in transgenic mice: association with development of olfactory neuroblastoma. J Virol 64: 3988–3991PubMedGoogle Scholar
  19. Koike S, Taya C, Kurata T, Abe S, Ise I, Yonekawa H, Nomoto A (1991) Transgenic mice susceptible to poliovirus. Proc Natl Acad Sci USA 88: 951–955PubMedCrossRefGoogle Scholar
  20. Koike S, Hohe H (1993) Poliovirus-sensitive transgenic mice as a new animal model. In: Brown F, Lewis BP (eds) Poliovirus Attenuation: Molecular Mechanisms and Practical Aspects. Dev Biol Stand Basel, Karger, 78, pp 101–107Google Scholar
  21. Lee TH, Finegold MJ, Shen R, DeMayo JL, Woo SL, Butel JS (1990) Hepatitis B virus transactivator X protein is not tumorigenic in transgenic mice. J Virol 64: 5939–5947PubMedGoogle Scholar
  22. Leonard JM, Abramczuk JW, Pezen D, Rutledge R, Belcher J, Hakim F (1988) Development of disease and virus recovery in transgenic mice containing proviral DNA. Science 242: 1665–1770PubMedCrossRefGoogle Scholar
  23. Maintenance and distribution of transgenic mice susceptible to human viruses (1993) WHO Bulletin 71: 497-502Google Scholar
  24. Morrey JD, Bourn SM, Bunch TD, Jackson MK, Sidwell R, Barrows L, Daynes R, Rosen CA (1991) In vivo activation of human immunodeficiency virus type 1 long terminal repeat report by UV type A(UV-A) light plus psoralen and UV-B light in the skin of transgenic mice. J Virol 65: 5045–5051PubMedGoogle Scholar
  25. Ren R, Costantini F, Gorgacz E, Lee JJ, Racaniello VR (1990) Transgenic mice expressing a human poliovirus receptor: a new model for poliomyelitis. Cell 63: 353–362PubMedCrossRefGoogle Scholar
  26. Small JA, Bieberich C, Chotbi Z, Hess J, Scangos G, Clements JE (1989) The visna virus long terminal repeat directs expression of a reporter gene in activated macrophages, lymphocytes, and the central nervous systems of transgenic mice. Virol63: 1891–1896Google Scholar
  27. Tinsley JM, Fisher C, Searle PF (1992) Abnormalaties of epidermal differentiation associated with expression of the human papillomavirus type 1 early region in transgenic mice. J Gen Virol 73: 1251–1260PubMedCrossRefGoogle Scholar
  28. Vogel J, Hinrichs SH, Napolitano L, Ngo L, Jay G (1991) Liver cancer in transgenic mice carrying the human immunodeficiency virus tat gene. Cancer Res 51: 6686–6690PubMedGoogle Scholar
  29. Vogel J, Cepeda M, Tschachler E, Napolitano L, Jay G (1992) UV activation of human immunodeficiency virus gene expression in transgenic mice. J Virol 66; 1–5PubMedGoogle Scholar
  30. WHO/ICLAS Guidelines for Maintenance of Animals (1992) WHO, GenevaGoogle Scholar
  31. Wilson JB, Weinbegr W, Jonson R, Yuspa S, Levine A (1990) Expression of the BNLF-1 oncogene of Epstein-Barr virus in the skin of transgenic mice induces hyperplasia and aberrant expression of keratin 6. Cell 61: 1315–1327PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • Y. Ghendon
    • 1
  • P.-H. Lambert
    • 1
  1. 1.World Health OrganizationSwitzerland

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