Regulation of Expression and Pathogenic Potential of Human Foamy Virus In Vitro and in Transgenic Mice

  • A. Aguzzi
  • S. Marino
  • R. Tschopp
  • A. Rethwilm
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 206)

Abstract

Increasing scientific interest in the foamy virus subgroup of retroviruses during the last few years has been due to two discoveries; (1) the molecular biology of foamy viruses shows some close similarities to that of lentiviruses and of the HTLV/BLV group of retroviruses, in addition to some features which set the foamy viruses apart from all other retroviruses. Moreover (2), transgenic mouse systems demonstrated for the first time a pathogenic potential of foamy viruses, i.e., induction of a fatal encephalopathy and myopathy in mice expressing various combinations of foamy virus genes.

Keywords

Sarcoma Neurol Cyclosporin Neuroblastoma Crest 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • A. Aguzzi
    • 1
  • S. Marino
    • 1
  • R. Tschopp
    • 1
  • A. Rethwilm
    • 2
  1. 1.Institute of Neuropathology, Department of PathologyUniversity of ZürichZürichSwitzerland
  2. 2.Institute of VirologyUniversity of WürzburgWürzburgGermany

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