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Die physiologische Barrierefunktion des Dünndarmes

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Ökosystem Darm VI

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Zusammenfassung

Die Bedeutung der epithelialen Barriere des Darmes besteht v. a. in zwei Funktionen. Zum einen schützt sie den Organismus vor dem Eindringen von in der Nahrung enthaltenen Noxen und Antigenen. Diese Schutzfunktion gegen die Umgebung kann bei der enormen Gesamtoberfläche des Darmes in ihrer Bedeutung gar nicht hoch genug eingeschätzt werden. Zum anderen trägt sie zur Aufrechterhaltung des „milieu interieur“ bei. So ist die epitheliale Barriere eine Voraussetzung für die Wirksamkeit vektorieller Transportprozesse. Dieser Zusammenhang ist aus Untersuchungen an auf impermeablen Supporten wachsenden Zellkulturen bekannt, wo die Bildung von „domes“ als Ausdruck von Netto-Ionenresorption an das Vorhandensein eines intakten Schlußleistennetzes geknüpft ist. Ohne epitheliale Barriere würden die gerade resorbierten Ionen sofort wieder zurückströmen.

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Authors
  1. J.-D. Schulzke
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  2. M. Fromm
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Editor information

Editors and Affiliations

  1. Medizinische Klinik II, Zentrum der Inneren Medizin, Klinikum der Johann-Wolfgang-Goethe-Universität, Theodor-Stern-Kai 7, 60590, Frankfurt a. M., Deutschland

    Wolfgang F. Caspary

  2. Institut für Medizinische Mikrobiologie und Hygiene, Universität Freiburg, Hermann-Herder-Str. 11, 79104, Freiburg, Deutschland

    Manfred Kist

  3. Medizinische Klinik und Poliklinik, Innere Medizin II, Universität des Saarlandes, 66421, Homburg/Saar, Deutschland

    Martin Zeitz

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© 1994 Springer-Verlag Berlin Heidelberg

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Schulzke, JD., Fromm, M. (1994). Die physiologische Barrierefunktion des Dünndarmes. In: Caspary, W.F., Kist, M., Zeitz, M. (eds) Ökosystem Darm VI. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85187-2_7

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  • DOI: https://doi.org/10.1007/978-3-642-85187-2_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-58548-0

  • Online ISBN: 978-3-642-85187-2

  • eBook Packages: Springer Book Archive

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