Skip to main content
SpringerLink
Log in

Wirkung nichtsteroidaler Antirheumatika auf die intestinale Permeabilität

  • Conference paper
Book cover Ökosystem Darm VI

  • 44 Accesses

Zusammenfassung

Lange ist bekannt, daß nichtsteroidale Antirheumatika (NSAR) Veränderungen der gastroduodenalen Mukosa sowie gehäuft GI-Blutungen bewirken [1, 2, 9, 11–13, 15, 17, 23]. Die morphologischen und funktionellen Schädigungen der Magenmukosa durch NSAR sind insbesondere durch das lokal wirkende Aspirin so eindeutig und reproduzierbar, daß zahlreiche endoskopische Schädigungsscores entwickelt wurden, z. B.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Agrawal NG, Saggioro A (1991)Treatment and prevention of NSAID induced gastroduodenal mucosal damage. J Rheumatol 18 (Suppl 28 ): 15–18

    Google Scholar 

  2. Allison MC, Howatson AG, Torrance CJ, Lee FD, Russell RI (1992) Gastrointestinal damage associated with the use of nonsteroidal antiinflammatory drugs. New Engl J Med 327: 749–754

    Article  PubMed  CAS  Google Scholar 

  3. Bjarnason I, Fehilly B, Menzies IS, Levi AJ (1991) Importance of local versus systemic effects of non-steroidal anti-inflammatory drugs in increasing small intestinal permeability in man. Gut 32: 275–277

    Article  PubMed  CAS  Google Scholar 

  4. Bjarnason I, Hayllar J, Smethurst P, Price A, Gumpel MJ (1992) Metronidazole reduces intestinal inflammation and blood loss in non-steroidal anti-inflammatory drug induced enteropathy. Gut 33: 1204–1208

    Article  PubMed  CAS  Google Scholar 

  5. Bjarnason I, Hayllar J, MacPherson AJ, Russell AS (1993) Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans. Gastroenterology 104: 1832–1847

    PubMed  CAS  Google Scholar 

  6. Bjarnason I, Smethurst P, MacPherson A, Walker F, McElnay JC, Passmore AP et al. (1992) Glucose and citrate reduce the permeability changes caused by indomethacin in humans. Gastroenterology 102: 1546–1550

    PubMed  CAS  Google Scholar 

  7. Bjarnason I, Williams P, Smethurst P, Peters TJ, Levi AJ (1986) The effect of NSAIDs and prostaglandins on the permeability of the human small intestine Gut 27: 1292–1297

    CAS  Google Scholar 

  8. Bjarnason I, Zanelli G, SmithT, Prouse P, De Lacey G, Gumpel MJ et al. (1987) Nonsteroidal antiinflammatory drug induced inflammation in humans. Gastroenterology 93: 480–489

    PubMed  CAS  Google Scholar 

  9. Brooks PM, Day RD (1991) Nonsteroidal antiinflammatory drugs — differences and similarities. New Engl J Med 324: 1716–1725

    Article  PubMed  CAS  Google Scholar 

  10. Davies GR, Wilkie ME, Rampton DS (1993) Effects of metronidazole and misoprostol on indomethacin-induced changes in intestinal permeability. Dig Dis Sci 38: 417–425

    Article  PubMed  CAS  Google Scholar 

  11. Graham DY (1989) Prevention of gastroduodenal injury induced by chronic nonsteroidal anti-inflammatory drug therapy. Gastroenterology 96: 675–681

    PubMed  CAS  Google Scholar 

  12. Graham DY, Smith JL (1988) Gastroduodenal complications of chronic NSAID therapy. Am J Gastroenterol 83: 1081–1084

    PubMed  CAS  Google Scholar 

  13. Griffin MR, Piper JM, Daugherty JR, Snowden M, Ray WA (1991) Nonsteroidal anti-inflammatory drug use and increased risk for peptic ulcer disease in elderly persons. Ann Intern Med 114: 257–263

    PubMed  CAS  Google Scholar 

  14. Hollander D (1993) Permeability in Crohn’s disease: altered barrier functions in healthy relatives. Gastroenterology 104: 1848–1851

    PubMed  CAS  Google Scholar 

  15. Ivey KJ, Rooney PJ (1989) Non-steroidal anti-inflammatory drugs and the gastrointestinal tract. Baillière’s Clin Rheumatol 3: 393–409

    Article  PubMed  CAS  Google Scholar 

  16. Jenkins AP, Trew DR, Crump BJ, Nukajam WS, Foley JA, Menzies IS et al. (1991) Do non-steroidal anti-inflammatory drugs increase colonic permeability? Gut 32: 66–69

    Article  PubMed  CAS  Google Scholar 

  17. Langman MJS (1989) Epidemiologic evidence on the association between peptic ulceration and antiinflammatory drug use. Gastroenterology 96: 640–646

    PubMed  CAS  Google Scholar 

  18. Langman MJS, Morgan L, Worrall A (1985) Use of anti-inflammatory drugs by patients with small or large bowel perforation and haemorrhage. Br Med J 290: 347–349

    Article  CAS  Google Scholar 

  19. Madara JL (1988) Tight junction dynamics: is its paracellular transport regulated? Cell 53: 497–498

    Article  PubMed  CAS  Google Scholar 

  20. Madara JL (1989) Loosening tight junctions — lessons from the intestine. J Clin Invest 83: 1089–1094

    Article  PubMed  CAS  Google Scholar 

  21. Madara JL (1991) Epithelia: Biological principles of organization. In: Yamada T (ed) Textbook of Gastroenterology. Lippincott, Philadelphia p 102–118

    Google Scholar 

  22. Madara JL, Barenberg D, Carlson S (1986) Effects of cytochalasin D on occluding junctions of intestinal absorptive cells: further evidence that the cytoskleleton may influence paracellular permeability and junctional charge selectivity. J Biol Chem 102: 2125–2136

    CAS  Google Scholar 

  23. McCarthy DM (1989) Nonsteroidal antiinflammatory drug-induced ulcers: management by traditional therapies. Gastroenterology 96: 662–674

    PubMed  CAS  Google Scholar 

  24. Mielants H, Goemaere S, De Vos M, Schelstraete K, Goethals K, Maertens M et al. (1991) Intestinal mucosal permeability in inflammatory rheumatic disease. I. Role of antiinflammatory drugs. J Rheumatol 18: 389–393

    PubMed  CAS  Google Scholar 

  25. Nygard G, Anthony A, Piasecki C, Trevethick MA, Hudson M, Dhillon AP et al. (1994) Acute indomethacin-induced jejunal injury in the rat: early morphological and biochemical changes. Gastroenterology 106: 567–575

    PubMed  CAS  Google Scholar 

  26. Oman H, Henriksson K, Blomquist L, Johannson SGO (1992) Increased intestinal permeability to polysurcrose in NSAID-treated patients. Eur J Gastroenterol Hepatol 4: 235–240

    Google Scholar 

  27. Somasundaram S, MacPherson AJ, Hayllar J, Sarachandra P, Bjarnason I (1992) Enterocyte mitochondrial damage due to NSAID in the rat. Gut 33 ( Suppl ): S5

    Google Scholar 

  28. Spitz J, Hecht G, Taveras M, Aoys E, Alverdy J (1994) The effect of dexamethasone administration on rat intestinal permeability: the role of bacterial adherence. Gastroenterology 106: 35–41

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. W. F. Caspary
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Medizinische Klinik II, Zentrum der Inneren Medizin, Klinikum der Johann-Wolfgang-Goethe-Universität, Theodor-Stern-Kai 7, 60590, Frankfurt a. M., Deutschland

    Wolfgang F. Caspary

  2. Institut für Medizinische Mikrobiologie und Hygiene, Universität Freiburg, Hermann-Herder-Str. 11, 79104, Freiburg, Deutschland

    Manfred Kist

  3. Medizinische Klinik und Poliklinik, Innere Medizin II, Universität des Saarlandes, 66421, Homburg/Saar, Deutschland

    Martin Zeitz

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Caspary, W.F. (1994). Wirkung nichtsteroidaler Antirheumatika auf die intestinale Permeabilität. In: Caspary, W.F., Kist, M., Zeitz, M. (eds) Ökosystem Darm VI. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85187-2_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-85187-2_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-58548-0

  • Online ISBN: 978-3-642-85187-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation