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Pathologie der Epilepsien

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Pathologie
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Zusammenfassung

Während im Erwaehsenenalter die großen, tonisehklonisehen, generalisierten Krampfanfälle (aueh als “gemeinsame Endstreeke” untersehiedlieher Anfallstypen) und die komplexen Partialantiille (psyehomotorisehe Antälle) überwiegen, treten im Kindesalter aueh sogenannte kleine Antälle untersehiedlieher Phänomenologie auf. Das klinisehe Bild wird nieht zuletzt bestimmt dureh Ursprungsort und Ausbreitungsmuster der pathologischen Entladungen. Klinisch warden die verschiedenen Epilepsieformen teils nach ätiologischen, teils nach phänomenologischen Kriterien aufgeteilt.

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Literatur

  1. McNamara JO (1992) The neurobiological basis of epilepsy. TINS 15:357–359

    PubMed  CAS  Google Scholar 

  2. Peiffer J (1992) Zur Neuropathologie der Temporallappenepilepsien. In: Kohlmeyer K, (ed) Der Temporallappen. Schnetztor, Konstanz, S 74–89

    Google Scholar 

  3. Peiffer J (1993) Neuronale Schäden durch Epilepsien. Klinischneuropathologische Korrelationsversuche zur Frage der Krampfschäden beim Menschen. Thieme, Stuttgart

    Google Scholar 

  4. Schmidt-Kastner R, Freund TF (1991) Selective vulnerability of the hippocampus in brain ischemia. Neuroscience 40: 599–636

    Article  PubMed  CAS  Google Scholar 

  5. Auer RN, Ingvar M, Nevander G et al. (1986) Early axonal lesion and preserved microvasculature in epilepsy-induced hypermetabolic necrosis of the substantia nigra. Acta N europathol 71: 207–215

    CAS  Google Scholar 

  6. Battino D, Binelli S, Caccamo ML et al. (1992) Malformations in offspring of 305 epileptic women: a prospective study. Acta Neurol Scand 85: 204–207

    Article  PubMed  CAS  Google Scholar 

  7. Bouchet, Cazauvielh (1825) De I’épilepsie considérée dans ses rapports avec I’aliénation mentale. Arch Gen Med 9: 510–542

    Google Scholar 

  8. Chadwick D (1990) Diagnosis of epilepsy. Lancet 336: 291–195

    Article  PubMed  CAS  Google Scholar 

  9. Cohen N, Duke RC, Fadok VA, Sellins S (1992) Apoptosis and programmed cell death in immunity. Ann Rev Immunol 10: 267–293

    Article  CAS  Google Scholar 

  10. Dressler D, Voth E, Feldmann M et al. (1989) The development of an epileptogenic focus. J Neurol 236: 300–302

    Article  PubMed  CAS  Google Scholar 

  11. Evans M, Griffith T, Meldrum B (1983) Early changes in the rat hippocampus following seizures induced by bicculline or L-allylglycine: A light and electron microscope study. Neuropathol Appl Neurobiol 9: 39–52

    Article  PubMed  CAS  Google Scholar 

  12. Grosz-Selbeck G (1988) Valproat - ein risikoreiches Medikament? Epilepsie-Blätter 1: 7–13

    Google Scholar 

  13. Hirsch CS, Martin DL (1971) Unexpected death in young epileptics. Neurology 21: 682–690

    PubMed  CAS  Google Scholar 

  14. Ingvar M, Morgan PF, Auer RN (1988) The nature and timing of excitotoxic neuronal necrosis in the cerebral cortex, hippocampus and thalamus due to f1urothyl-induced status epilepticus. Acta Neuropathol 75: 362–369

    Article  PubMed  CAS  Google Scholar 

  15. Kaufmann HG, Finn R, Bourdillon RE (1966) Fat embolism following an epileptic seizure. Brit Med J 1: 1081

    Article  Google Scholar 

  16. Ketz E (1974) Brain tumours and epilepsy. In: Vinken PJ, Bruyn GW, (eds) Tumors of the brain and skull, part I. North Holland, Amsterdam (Handbook of Clinical Neurology, vol 16, pp 254–269)

    Google Scholar 

  17. Kiessling M, Kleihues P (1981) Regional protein synthesis in the rat brain during bicuccullin-induced epileptic seizures. Acta Neuropathol 55: 157–162

    Article  PubMed  CAS  Google Scholar 

  18. Kirino T (1982) Delayed neuronal death in the gerbil hippocampus following ischemia. Brain Res 239: 57–69

    Article  PubMed  CAS  Google Scholar 

  19. Lund M (1968) Die Mortalität von Epileptikern. Der Medizin Sachverstandige 64: 77–97

    Google Scholar 

  20. McDonald JW, Garofalo EA, Hood T et al. (1991) Altered excitatory and inhibitory amino acid receptor binding in hippocampus of patients with temporal epilepsy. Ann Neurol 29: 529–541

    Article  PubMed  CAS  Google Scholar 

  21. Olney JW, De Gubareff T, Sioviter RS (1983) “Epileptic” brain damage in rats induced by sustained electrical stimulation of the perforant path. I. Ultrastructural analysis of acute hippocampal pathology. Brain Res Bull 10: 699–712

    Article  PubMed  CAS  Google Scholar 

  22. Olsen RW, Wamsley JK, McCabe RT et al. (1986) Midbrain GABA receptor deficit in genetic animal models of epilepsy. In: Nistico G, Morselli PI, Lloyd KG et al. (eds) Neurotransmitters, seizures, and epilepsy. III. Raven Press, New York, pp 279–291

    Google Scholar 

  23. Patry G, Lyagoubi S, Tassinari CA (1971) Subclinical electrical status epilepticus induced by sleep in children. A clinical and electroencephalographic study of six cases. Arch Neurol 24: 242–252

    Article  PubMed  CAS  Google Scholar 

  24. Reid SA, Sypert GW, Boggs WM, Willmore LJ (1979) Histopathology of the ferric-induced chronic epileptic focus in cat: A Golgy study. Exp Neurol 66: 205–219

    Article  PubMed  CAS  Google Scholar 

  25. Ribak CE, Harris AB, Vaughn JE, Roberts E (1979) Inhibitory, GABAergic nerve terminals decrease at sites of focal epilepsy. Science 205: 211–214

    Article  PubMed  CAS  Google Scholar 

  26. Ribak CE, Jourbran C, Kesslak JP, Bakay RAE (1989) A selective decrease in the number of GABAergic somata occurs in preseizing monkeys with alumina gel granuloma. Epilepsy Res 4: 126–138

    Article  PubMed  CAS  Google Scholar 

  27. Ryvlin P, Philippon B, Cinotti L, et al. (1992) Functional neuroimaging strategy in temporal lobe epilepsy: A comparative study of 18FDG-PET and 99mTc-HMPAO-Spect. Ann Neurol 31: 650–656

    Article  PubMed  CAS  Google Scholar 

  28. Sander JWAS, Hart YM, Trimble MR, Shorvon SD (1991) Vigabatrin and psychosis. J Neurol Neurosurg Psychiatry 54: 435–439

    Article  PubMed  CAS  Google Scholar 

  29. Scheffner D (1988) Valproat - ein risikoreiches Medikament? Epilepsie-Blätter 1: 14

    Google Scholar 

  30. Schulze KD, Braak H (1978) Hirnwarzen. Z Mikrosk Anat Forsch (Leipzig) 4: 609--623

    Google Scholar 

  31. Schwade ED, Otto O (1954) Mortality in epilepsy. JAMA 156: 1526

    Article  Google Scholar 

  32. Shorvon SD (1991) Epidemiologie, Klassifikation, Spontanverlauf und Genetik der Epilepsien. In: Rabending G, (ed) Epilepsie. Grundlagen und Perspektiven. Schwer, Stuttgart, S3-S5

    Google Scholar 

  33. Sioviter RS (1987) Decreased hippocampal inhibition and a selective loss of interneurons in experimental epilepsy. Science 235: 73–76

    Article  Google Scholar 

  34. Sioviter RS, Sollas AL, Barbaro NM, Laxer KD (1991) Calciumbinding protein (calbindin-D28K) and parvalbumin immunohistochemistry in the normal and epileptic human hippocampus. J Comp Neurol 308: 381–396

    Article  Google Scholar 

  35. Sutula T., Cascino G, Cavazos J., Parada I, Ramirez L (1989) Mossy fiber synaptic reorganization in the epileptic human temporal lobe. Ann Neurol 26: 321–330

    Article  PubMed  CAS  Google Scholar 

  36. Theodore WH, Katz D., Kufta C et al. (1990) Pathology of temporallobe foci: Correlation with CT. MRI. and PET. Neurology 40: 797–803

    PubMed  CAS  Google Scholar 

  37. Veith G (1979) Über die Krampfschädigung des Gehirns. Bethel Heft 20: 21–42

    Google Scholar 

  38. Wasterlain CG (1979) Does anoxemia playa role in the effects of neonatal seizures on brain growth? Eur Neurol 18: 222–229

    Article  PubMed  CAS  Google Scholar 

  39. Ziegler HK, Kamecke A (1967) Über den unerwarteten Tad von Epileptikern. Nervenarzt 38: 343–347

    PubMed  CAS  Google Scholar 

  40. Zielinski JJ (1974) Epilepsy and mortality rate and cause of death. Epilepsia 15: 191–201

    Article  PubMed  CAS  Google Scholar 

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© 1995 Springer-Verlag Berlin Heidelberg

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Peiffer, J. (1995). Pathologie der Epilepsien. In: Remmele, W., Peiffer, J., Schröder, J.M. (eds) Pathologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85179-7_7

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  • DOI: https://doi.org/10.1007/978-3-642-85179-7_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-85180-3

  • Online ISBN: 978-3-642-85179-7

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